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  4. Human Netrin-4,Ntn4 ELISA Kit

Human Netrin-4,Ntn4 ELISA Kit

  • 中文名稱：
    人軸突生長誘向因子4(Ntn4)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E11900h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人軸突生長誘向因子4(Ntn4)酶聯(lián)免疫試劑盒（CSB-E11900h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的NTN4含量。NTN4是一種編碼Netrin蛋白家族成員的基因，Netrin蛋白在多種生物過程中發(fā)揮作用，包括軸突導向、腫瘤發(fā)生和血管生成。NTN4在乳腺癌中表現(xiàn)出降低的趨勢，與乳腺癌細胞的遷移和侵襲相關。研究發(fā)現(xiàn)，NTN4通過其N端的Laminin_N結構域與細胞外的Wnt配體結合，抑制Wnt信號通路，從而發(fā)揮抑癌作用。試劑盒檢測范圍為7.8 ng/ml-500 ng/ml，適用于體外培養(yǎng)細胞上清、動物組織提取液或體液樣本的科研檢測，可支持神經(jīng)生物學研究、腫瘤微環(huán)境分析、血管生成機制探索等實驗需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Beta netrin ELISA Kit; Beta-netrin ELISA Kit; FLJ23180 ELISA Kit; Hepar derived netrin like protein ELISA Kit; Hepar-derived netrin-like protein ELISA Kit; NET4_HUMAN ELISA Kit; Netrin-4 ELISA Kit; Netrin4 ELISA Kit; NTN 4 ELISA Kit; NTN4 ELISA Kit; PRO3091 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    7.8 ng/ml -500 ng/ml
  • 靈敏度：
    1.95 ng/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 線性度：
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻

產(chǎn)品評價

靶點詳情

  • 功能：
    May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.
  • 基因功能參考文獻：
    1. Endogenous NTN4/NEO1 maintain neuroblastoma growth via both pro-survival and pro-migratory molecular signaling. PMID: 28038459
    2. Data indicate that OR3A4 upregulation contributes to metastasis and tumorigenesis in gastric cancer by regulating the activation of PDLIM2, MACC1, NTN4, and GNB2L1. PMID: 26863570
    3. NTN4 is reduced in breast cancer tissues and NTN4 is associated with breast cancer cell migration and invasion via regulation of epithelial mesenchymal transition (EMT)-related biomarkers. PMID: 27840993
    4. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
    5. inhibits placental microvascular endothelial cells proliferation, tube-like formation, migration and spheroid sprouting PMID: 26390805
    6. Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways PMID: 25909166
    7. Increased expression of miR-20a may play an important role in the pathogenesis of ovarian endometriosis by suppressing NTN4 expression. PMID: 24972566
    8. Increased maternal netrin-4 levels in IUGR neonates may reflect in utero hypoxia, while the negative correlations between fetal netrin-1 and -4 levels may exert the dynamic balance between their angio- and anti-angiogenic properties. PMID: 24716747
    9. NTN4 acts as a positive regulator for TC axon branching through activity-dependent expression PMID: 25288737
    10. NETRIN-4 protects glioblastoma cells FROM temozolomide induced senescence. PMID: 24265816
    11. NTN4 expression was downregulated in cervical cancer tissues compared to normal controls, and in vivo mRNA level of NTN4 inversely correlated with miR-196a expression. PMID: 24120501
    12. pattern of distribution suggests that a functional netrin-4-neogenin pathway might be restricted to syncytiotrophoblasts, mesenchymal cells, and villous endothelial cells PMID: 22705235
    13. glioma cells reduce netrin-4 expression to decrease its inhibitory effects. PMID: 22496621
    14. Netrin-4 is upregulated in breast carcinoma effusions compared to corresponding solid tumors PMID: 20730893
    15. The alpha6beta1 integrin is a netrin-4 receptor in endothelial cells. PMID: 21799154
    16. NT-4 overexpression decreases tumor growth and carcinomatosis, probably via an antiangiogenic effect PMID: 21406174
    17. Loss of NTN4 by methylation is associated with breast cancer. PMID: 19859801
    18. Netrin-4, at physiologic doses, induces proliferation, migration, adhesion, tube formation and survival of human lymphatic endothelial cells. PMID: 20407033
    19. NTN4, TRA1, and STC2 have roles in progression of breast cancer PMID: 17545519
    20. Knockdown of Netrin-4 expression in EC increased their ability to form tubular structures; Netrin-4 bound only to neogenin but not to Unc5B or Unc5C receptors PMID: 18719102
    21. A potential role for netrin-4 in regulating tumor growth. PMID: 19094984

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  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.
  • 組織特異性：
    Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13658

    OMIM: 610401

    KEGG: hsa:59277

    STRING: 9606.ENSP00000340998

    UniGene: Hs.201034