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  4. Human Neuritin(NRN1) ELISA kit

Human Neuritin(NRN1) ELISA kit

  • 中文名稱：
    人神經(jīng)突蛋白(NRN1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL016088HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人神經(jīng)突蛋白(NRN1)酶聯(lián)免疫試劑盒（CSB-EL016088HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的NRN1含量。人神經(jīng)突蛋白(NRN1)是一種神經(jīng)營養(yǎng)因子，促進神經(jīng)突生長、樹突生長、神經(jīng)元遷移和突觸成熟，參與神經(jīng)發(fā)育、突觸可塑性和脊髓軸突再生，在阿爾茨海默癥等神經(jīng)退行性疾病中發(fā)揮重要作用。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于神經(jīng)生物學基礎(chǔ)研究，如神經(jīng)損傷修復模型、腦組織蛋白表達譜分析，或體外藥物干預實驗中對NRN1動態(tài)變化的監(jiān)測，為探索神經(jīng)系統(tǒng)相關(guān)疾病的分子機制提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Neuritin 1 ELISA Kit; Neuritin ELISA Kit; NRN ELISA Kit; Nrn1 ELISA Kit; NRN1_HUMAN ELISA Kit; OTTHUMP00000015989 ELISA Kit; RP3 380B8.2 protein ELISA Kit
  • 縮寫：
    NRN1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human NRN1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %86
    Range %81-92
    1:2Average %95
    Range %88-99
    1:4Average %93
    Range %86-98
    1:8Average %100
    Range %96-107
  • 回收率：
    The recovery of human NRN1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8580-89
    EDTA plasma (n=4)9086-96
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.590 2.780 2.685 2.491
    10002.271 2.289 2.280 2.086
    5001.825 1.876 1.851 1.657
    2501.384 1.397 1.391 1.197
    1250.827 0.865 0.846 0.652
    62.50.581 0.604 0.593 0.399
    31.250.357 0.368 0.363 0.169
    00.196 0.192 0.194 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻

產(chǎn)品評價

靶點詳情

  • 功能：
    Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
  • 基因功能參考文獻：
    1. NRN1 is expressed more extensively in melanoma than in normal melanocytes and healthy tissue. Secreted NRN1 seems to play a role also in earlier phases of melanoma development as we can discover NRN1 over-expression to be associated to primary melanoma PMID: 27901477
    2. results suggest that DTNBP1 and NRN1 genes show a joint effect on the risk for schizophrenia spectrum disorders. Although the precise mechanism underlying this effect is unclear, the fact that these genes have been involved in synaptic maturation, connectivity and glutamate signalling suggests that our findings could be of value as a link to the schizophrenia aetiology. PMID: 27855309
    3. NRN1 is associated with depressive symptoms and executive function in a non-clinical sample. Our results also suggest that the role of NRN1 seems to be modulated by BDNF. PMID: 28107668
    4. On analysis of the expression of NRN1 in SMA patients for the first time, NRN1 could be a potential modifier gene PMID: 27279027
    5. Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. PMID: 27307045
    6. (i) NRN1 variability is a shared risk factor for both schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), (ii) NRN1 may have a selective impact on age at onset and intelligence in SSD. PMID: 26700405
    7. Data indicate that neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells PMID: 26208391
    8. Neuritin is reduced in the brains of Alzheimer's disease (AD) patients. PMID: 25101829
    9. MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression PMID: 25036738
    10. we found neuritin is overexpressed in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma PMID: 20405246
    11. Data show that SMN and HuD form a complex in spinal motor axons, and that both interact with cpg15 mRNA in neurons. PMID: 21652774
    12. NRN1 polymorphisms have roles in fluid intelligence in schizophrenia PMID: 19569075
    13. CPG15 and CPG15-2 perform similar cellular functions but may play distinct roles in vivo through their cell-type- and tissue-specific transcriptional regulation PMID: 18265009

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.
  • 蛋白家族：
    Neuritin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17972

    OMIM: 607409

    KEGG: hsa:51299

    STRING: 9606.ENSP00000244766

    UniGene: Hs.103291