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  4. Human Neuronal Pentraxin-1(NPTX-1) ELISA kit

Human Neuronal Pentraxin-1(NPTX-1) ELISA kit

  • 中文名稱：
    人神經(jīng)穿透素1(NPTX-1 )酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E14336h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人神經(jīng)穿透素1(NPTX-1 )酶聯(lián)免疫試劑盒（CSB-E14336h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的NPTX1含量。試劑盒檢測范圍為7.8 pg/mL-500 pg/mL，適用于神經(jīng)科學(xué)領(lǐng)域的基礎(chǔ)研究，例如探索阿爾茨海默病、帕金森病等神經(jīng)退行性疾病模型中NPTX-1的表達(dá)變化，或評估藥物干預(yù)對神經(jīng)遞質(zhì)通路的影響。其寬泛的檢測范圍可覆蓋生理及病理狀態(tài)下血清/血漿樣本的濃度梯度，為體外實(shí)驗(yàn)提供可靠的數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Neuronal pentraxin I ELISA Kit; Neuronal pentraxin-1 ELISA Kit; NP 1 ELISA Kit; NP-I ELISA Kit; NP1 ELISA Kit; Nptx1 ELISA Kit; NPTX1_HUMAN ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    7.8 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human NPTX-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %93
    Range %89-97
    1:2Average %103
    Range %96-105
    1:4Average %93
    Range %89-97
    1:8Average %98
    Range %94-102
  • 回收率：
    The recovery of human NPTX-1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9793-101
    EDTA plasma (n=4)9286-96
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    5002.642 2.443 2.543 2.395
    2501.838 1.737 1.788 1.640
    1251.034 1.166 1.100 0.952
    62.50.613 0.597 0.605 0.457
    31.20.398 0.401 0.400 0.252
    15.60.264 0.255 0.260 0.112
    7.80.196 0.188 0.192 0.044
    00.149 0.147 0.148
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
  • 基因功能參考文獻(xiàn)：
    1. NPTX1 is down-regulated in colon cancer. In addition, NPTX1 inhibits the proliferation of colon cancer cells via decreasing cyclin A2 and CDK2. PMID: 29345391
    2. NPTX1 was significantly associated with bipolar disorder. PMID: 25053281
    3. findings suggest that lower NARP mRNA expression contributes to lower excitatory drive onto parvalbumin interneurons in schizophrenia. PMID: 26038830
    4. These results suggest that NPTX1 hypermethylation and consequent mRNA changes might be an important molecular mechanism in lung cancer. PMID: 25646694
    5. Taken together, these results demonstrate that NP1 gene is a target of as hypoxia inducible factor-1 alpha and it regulates NP1 expression by binding to hypoxia responsive elements in its promoter region. PMID: 25498504
    6. Long acting progestin contraceptive-enhanced NPTX1 secretion and reactive oxygen species generation in endometrial stromal cells impair endometrial endothelial cells survival resulting in a loss in vascular integrity. PMID: 25029423
    7. NPTX1 binds and inhibits TDGF1, and reduces both Nodal and BMP signaling. PMID: 24529709
    8. Neuronal pentraxin 1 transgene is a key factor for the synapse loss, the neurite damage, and the apoptotic neuronal death evoked by amyloid-beta protein, which regulates NP1 expression. PMID: 17151277
    9. The purpose of the present study was to assess the toxic effect of taipoxin in SCLC-cell lines and to determine if toxicity correlates to NPR and NP1 and NP2 expression levels. PMID: 16115696

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  • 亞細(xì)胞定位：
    Cytoplasmic vesicle, secretory vesicle.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7952

    OMIM: 602367

    KEGG: hsa:4884

    STRING: 9606.ENSP00000307549

    UniGene: Hs.514556