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  4. Human Pancreatic Polypeptide,PP ELISA Kit

Human Pancreatic Polypeptide,PP ELISA Kit

  • 中文名稱：
    人胰多肽(PP)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E09206h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人胰多肽(PP)酶聯(lián)免疫試劑盒（CSB-E09206h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的PP含量。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于基礎(chǔ)科研中探索PP在代謝調(diào)控、內(nèi)分泌信號通路中的作用機制，或用于評估藥物干預(yù)、病理模型下PP的動態(tài)變化，可滿足體外實驗、動物模型或細胞培養(yǎng)體系中PP表達水平的定量分析需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    PPY ELISA Kit; PNPPancreatic prohormone ELISA Kit; Pancreatic polypeptide ELISA Kit; PP ELISA Kit; Obinepitide) [Cleaved into: Pancreatic hormone ELISA Kit; PH); Pancreatic icosapeptide ELISA Kit; PI)] ELISA Kit
  • 縮寫：
    PP
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human PP in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %86
    Range %83-89
    1:2Average %99
    Range %84-102
    1:4Average %89
    Range %84-93
    1:8Average %97
    Range %94-100
  • 回收率：
    The recovery of human PP spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8995-94
    EDTA plasma (n=4)108104-112
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.353 2.369 2.361 2.239
    10001.470 1.420 1.445 1.323
    5000.795 0.763 0.779 0.657
    2500.473 0.498 0.486 0.364
    1250.315 0.328 0.322 0.200
    62.50.232 0.241 0.237 0.115
    31.250.171 0.179 0.175 0.053
    00.123 0.120 0.122
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.; The physiological role for the icosapeptide has not yet been elucidated.
  • 基因功能參考文獻：
    1. Fasting human pancreatic polypeptide (HPP) levels are similar in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC) and controls regardless of glycemic status. PMID: 29771765
    2. Because of its properties, the PP appears to be a useful marker of the endocrine insufficiency of the pancreas and a specific prognostic parameter of developing diabetes due to chronic pancreatitis PMID: 26766123
    3. Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after acute pancreatitis and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFalpha. Future research is warranted to investigate the signaling pathways that underlie these associations. PMID: 27918953
    4. GIP and pancreatic polypeptide plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls. PMID: 28027898
    5. Immunohistochemical distribution of this peptide in the epidermal skin (from abdomen, breast and face) of healthy women was analysed. PMID: 26002416
    6. The most important parameter in diagnosis of HG [Hyperemesis gravidarum ]was plasma PP level PMID: 25990478
    7. These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells. PMID: 25445712
    8. Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. PMID: 24375409
    9. The diagnostic accuracy of the tumor markers CgA, PP, and glucagon for pancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1 is low. PMID: 23956349
    10. These findings underscore the important role of the NPY-Y receptor system at several levels of the gut-brain axis in which NPY, peptide yy and pancreatic polypeptide operate both as neural and endocrine messengers--{REVIEW} PMID: 22979996
    11. Pancreatic polypeptide (and peptide tyrosine-tyrosine) increases in obese woman on caloric restriction following high protein liquid meals compared to high carbohydrate liquid meals. PMID: 23371976
    12. Data suggest that beta-cell function improves in overweight subjects with type 2 diabetes who lose weight by dieting; this change is associated with a decrease in PPY secretion (i.e., plasma PPY is decreased). PMID: 22673566
    13. Self-association of PPY with phospholipid micelles addressed the delivery issues of the peptide for diabetes treatment. PMID: 22399387
    14. Women with bulimia nervosa have significantly lower fasting and postprandial serum concentrations of pancreatic polypeptide (and GLP-1) than control subjects. PMID: 21813805
    15. Distribution of pancreatic polypeptide and peptide YY PMID: 11825640
    16. Pancreatic polypeptide in pancreatitis PMID: 11825647
    17. Pancreatic polypeptide-related tumors PMID: 11825648
    18. Autonomic neuropathy is associated with impaired neuropeptide Y and this peptide responses to insulin-induced hypoglycaemia in Type I diabetic patients. PMID: 12187924
    19. Early postprandial insulin and PP secretory responses were higher in Pima Indians compared with those of Caucasians. PMID: 14988250
    20. Pancreatic polypeptide contributes to the regulation of energy balance in humans. PMID: 15561938
    21. in healthy humans the presence of fat in the small intestine suppresses ghrelin secretion, and fat-induced suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide is dependent on fat digestion PMID: 15998659
    22. Inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. Is suggested to have physiological role in pancreatic postprandial counterregulation of gastric emptying and insulin secretion. PMID: 15998783
    23. human pancreatic polypeptide inhibits TFF2 secretion in a diurnal rhythm PMID: 16359755
    24. Age and sex may modulate the association between plasma PP level and the intra-abdominal fat area, suggesting that they may be determinants of parasympathetic activity. PMID: 17171555

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    NPY family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9327

    OMIM: 167780

    KEGG: hsa:5539

    STRING: 9606.ENSP00000225992

    UniGene: Hs.558368