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  4. Human Prokineticin-2(PROK2) ELISA kit

Human Prokineticin-2(PROK2) ELISA kit

  • 中文名稱：
    人前動(dòng)力蛋白2(PROK2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL018747HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人前動(dòng)力蛋白2(PROK2)酶聯(lián)免疫試劑盒（CSB-EL018747HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、組織勻漿樣本中的PROK2含量。PROK2即促動(dòng)素2，是分泌性蛋白。其作為重要靶點(diǎn)，在人體生理活動(dòng)如血管生成、神經(jīng)發(fā)育等方面發(fā)揮作用。研究機(jī)制方面，它主要通過與特定受體結(jié)合，激活下游信號通路，進(jìn)而影響細(xì)胞行為，目前在腫瘤、神經(jīng)系統(tǒng)疾病等研究中受關(guān)注。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL，該產(chǎn)品可為科研人員提供可靠工具，用于探索PROK2在生殖生物學(xué)、腫瘤發(fā)生機(jī)制或神經(jīng)內(nèi)分泌調(diào)控中的功能，亦可用于評估細(xì)胞模型、動(dòng)物組織或生物體液中的蛋白表達(dá)水平變化，為相關(guān)疾病的分子機(jī)制研究及藥物開發(fā)提供數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    BV8 ELISA Kit; Bv8 homolog ELISA Kit; MIT1 ELISA Kit; PK2 ELISA Kit; PROK2 ELISA Kit; PROK2_HUMAN ELISA Kit; Prokineticin-2 ELISA Kit; Protein Bv8 homolog ELISA Kit
  • 縮寫：
    PROK2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human PROK2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %97
    Range %91-104
    1:2Average %88
    Range %86-91
    1:4Average %99
    Range %85-106
    1:8Average %95
    Range %89-98
  • 回收率：
    The recovery of human PROK2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9489-97
    EDTA plasma (n=4)9893-105
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    4002.345 2.245 2.295 2.160
    2001.764 1.664 1.714 1.579
    1001.112 1.102 1.107 0.972
    500.713 0.693 0.703 0.568
    250.422 0.412 0.417 0.282
    12.50.305 0.295 0.300 0.165
    6.250.212 0.202 0.207 0.072
    00.135 0.134 0.135 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.
  • 基因功能參考文獻(xiàn)：
    1. The results indicate that PK2 over-production perpetuates psoriatic symptoms by creating PK-2-IL-1 vicious loop. PK2 is a central player in psoriasis and a promising psoriasis-specific target. PMID: 27887936
    2. Prokineticin-2 is correlated with various cardiometabolic risk factors. PMID: 26728949
    3. Data suggest that prokineticins (PROK1 and PROK2) and prokineticin receptors (PROKR1 and PROKR2) act as main regulators of physiological functions of ovary, uterus, placenta, and testis. [REVIEW] PMID: 26574895
    4. Suggest PROK2 as an angiogenic growth factor in colorectal cancer. PMID: 26317645
    5. study found a novel mutation in PROK2 in two male siblings presenting normosmic congenital hypogonadotropic hypogonadism, in whom a mutation in the GNRHR gene had been previously described, suggesting the possibility of a digenic inheritance PMID: 25531638
    6. PROK2 significantly increased in human fetal ovary across gestation. PMID: 26192875
    7. EG-VEGF, BV8, and PROKR2 gene expression is approximately five, four, and two times higher in cystic fibrosis lungs compared with controls. PMID: 26047640
    8. No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes PMID: 24002956
    9. PROK2 signaling in humans is not required for central circadian pacemaker function. PMID: 24423319
    10. A novel role of BV8 in promoting oncogenesis intrinsic to malignant cells of myeloid origin. PMID: 23548897
    11. We could not implicate the ligand PROK2 in congenital hypopituitarism and septo-optic dysplasia. PMID: 23386640
    12. Three PROKR2 mutations previously described in Kallmann syndrome and one new PROK2 mutation were found in patients with isolated congenital anosmia. PMID: 23082007
    13. Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells: key role of Stat3 signaling. PMID: 22528488
    14. Data suggest that elevated prokineticin 2 levels, as a consequence of gastrointestinal tract inflammation, induce visceral pain via prokineticin receptors. PMID: 22050240
    15. Patients with this genetic form of Kallmann syndrome have been reported to have a possible increased prevalence of obesity and sleep disorders, which may be related to the role of PROK2 in food intake and circadian rhythms (Review) PMID: 20389090
    16. Review. Role of prokineticins in inflammatory and contractile pathways at parturition in humans. PMID: 20172976
    17. Male patients carrying biallelic mutations in PROK2 or PROKR2 have a less variable and on average a more severe reproductive phenotype than patients carrying monoallelic mutations in these genes. PMID: 20022991
    18. Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. PMID: 12024206
    19. Bv8 and EG-VEGF, along with other factors such as VEGF-A, may maintain the integrity and also regulate proliferation of the blood vessels in the testis PMID: 12604792
    20. Paracrine role for the PKs and their receptors in endometrial vascular function. PMID: 15126578
    21. potentially modulates growth, survival, and function of cells of the innate and adaptive immune systems, possibly through autocrine or paracrine signaling mechanisms PMID: 15548611
    22. study demonstrated that prokineticin 1 and 2 and their receptors are expressed in human prostate and that their levels increased with prostate malignancy PMID: 16763065
    23. These findings reveal that insufficient prokineticin-signaling through PROKR2 leads to abnormal development of the olfactory system and reproductive axis in man. PMID: 17054399
    24. Homozygous loss-of-function PROK2 mutations cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism PMID: 17959774
    25. The identification of PROK2 biallelic mutations, that is, a missense mutation, p.R73C, and a frameshift mutation, c.163delA, in two out of 273 patients presenting as sporadic cases, is reported. PMID: 18285834
    26. PK2/Bv8 expression decreases as the liver evolves towards cancer and does not correlate with HCC angiogenesis PMID: 18300343
    27. Loss-of-function mutations in PROK2 and PROKR2 underlie both Kallmann syndrome (KS) and normosmic idiopathic hypogonadotropic hypogonadism (IHH). PMID: 18559922
    28. Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome. PMID: 18682503
    29. no mutations found in Kallmann syndrome PMID: 18723471
    30. Bv8 expression is regulated by several cytokines in a cell type-specific fashion PMID: 19336519

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  • 相關(guān)疾病：
    Hypogonadotropic hypogonadism 4 with or without anosmia (HH4)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    AVIT (prokineticin) family
  • 組織特異性：
    Expressed in the testis and, at low levels, in the small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18455

    OMIM: 607002

    KEGG: hsa:60675

    STRING: 9606.ENSP00000295619

    UniGene: Hs.528665