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  4. Human Proteasome activator complex subunit 1(PSME1) ELISA kit

Human Proteasome activator complex subunit 1(PSME1) ELISA kit

  • 中文名稱：
    人蛋白酶體激活劑復(fù)合物亞基1(PSME1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL018915HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人蛋白酶體激活劑復(fù)合物亞基1(PSME1)酶聯(lián)免疫試劑盒（CSB-EL018915HU）為雙抗夾心法ELISA試劑盒，定量檢測組織勻漿、細胞裂解物.樣本中的PSME1含量。PSME1是蛋白酶體復(fù)合物的必需亞基，參與蛋白質(zhì)降解，尤其與細胞生長、周期調(diào)控、凋亡相關(guān)。其通過調(diào)節(jié)蛋白酶體裂解模式，增強I類結(jié)合肽產(chǎn)生，對免疫蛋白酶體組裝和抗原加工至關(guān)重要。試劑盒檢測范圍為0.19 ng/ml-12.5ng/ml，科研人員可通過該產(chǎn)品探索PSME1在腫瘤微環(huán)境調(diào)控、神經(jīng)退行性疾病進程或自身免疫性疾病中的作用機制，也可用于評估藥物干預(yù)對蛋白酶體激活途徑的影響，為分子生物學(xué)研究、病理機制解析及靶向治療開發(fā)提供可靠的數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    11S regulator complex alpha subunit ELISA Kit; 11S regulator complex subunit alpha ELISA Kit; 29 kD MCP activator subunit ELISA Kit; 29kD MCP activator subunit ELISA Kit; Activator of multicatalytic protease subunit 1 ELISA Kit; IFI5111 ELISA Kit; IGUP I-5111 ELISA Kit; Interferon gamma IEF SSP 5111 ELISA Kit; Interferon gamma inducible protein 5111 ELISA Kit; Interferon gamma up regulated I 5111 protein ELISA Kit; Interferon gamma up-regulated I-5111 protein ELISA Kit; MGC8628 ELISA Kit; PA28a ELISA Kit; PA28alpha ELISA Kit; Proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) ELISA Kit; Proteasome activator 28 subunit alpha ELISA Kit; Proteasome activator complex subunit 1 ELISA Kit; Proteasome activator subunit 1 ELISA Kit; PSME1 ELISA Kit; PSME1_HUMAN ELISA Kit; REG-alpha ELISA Kit; REGalpha ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    tissue homogenates, cell lysates.
  • 檢測范圍：
    0.19 ng/ml-12.5ng/ml
  • 靈敏度：
    0.049 ng/ml
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    12.5

    2.871

    2.977

    2.924

    2.832

    6.25

    2.339

    2.435

    2.387

    2.295

    3.125

    1.637

    1.583

    1.610

    1.518

    1.56

    0.845

    0.804

    0.825

    0.733

    0.78

    0.502

    0.515

    0.509

    0.417

    0.39

    0.250

    0.238

    0.244

    0.152

    0.19

    0.173

    0.179

    0.176

    0.084

    0

    0.093

    0.091

    0.092

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
  • 基因功能參考文獻：
    1. Such a modulation of proteasome activity is explained, at least in part, by the circadian expression of both Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and the proteasome activator PA28ab PMID: 26944190
    2. Results show that PA28alpha was found to be overexpressed in oral squamous cell carcinoma cell lines and tumor tissues. High expression of PA28alpha was significantly associated with recurrence and poorer overall survival. PMID: 26892607
    3. Constitutive expression of PA28 and ERAP1 in melanoma cells indicate that both interfere with MART-1(26-35) epitope generation even in the absence of IFN-gamma PMID: 26399368
    4. PA28 is a tumor marker and a potential target for therapeutic intervention in prostate cancer. PMID: 23918357
    5. Reduction in ATP levels triggers immunoproteasome activation by the 11S (PA28) regulator during early antiviral response mediated by IFNbeta in mouse pancreatic beta-cells. PMID: 23383295
    6. the first evidence of a novel ovarian cancer-specific marker PMID: 22532226
    7. PA28 selectively up-regulates the presentation of viral MHC class I epitopes and that down regulation PA28 in tumor cells results in impaired presentation of a human TRP2 tumor antigen. PMID: 12200048
    8. The relationship between anti-PA28alpha and Ki antibodies suggests the importance of an antigen-driven system in the induction of an autoimmune response to PA28 complex. PMID: 14760793
    9. DJ-1 and PA28alpha may have roles in the onset of hepatocarcinogenesis PMID: 17671684
    10. the 11S proteasome activator complex, Reg alpha fragment, may have a role in ovarian cancer PMID: 17939699
    11. bortezomib-adapted HL-60 cells showed increased expression and proteasome association of the 11S proteasome activator PMID: 19225532

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  • 蛋白家族：
    PA28 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9568

    OMIM: 600654

    KEGG: hsa:5720

    STRING: 9606.ENSP00000372155

    UniGene: Hs.75348