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  4. Human Protocadherin-10(PCDH10) ELISA kit

Human Protocadherin-10(PCDH10) ELISA kit

  • 中文名稱：
    人原鈣粘蛋白-10(PCDH10)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL017525HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人原鈣粘蛋白-10(PCDH10)酶聯(lián)免疫試劑盒（CSB-EL017525HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的PCDH10含量。PCDH10 即原鈣黏蛋白 10，它是一種腫瘤抑制基因。在研究機制方面，它可能通過調(diào)節(jié)細胞黏附、遷移等過程影響腫瘤發(fā)生發(fā)展，其表達缺失與多種腫瘤的侵襲、轉(zhuǎn)移及預(yù)后不良相關(guān)，是癌癥研究領(lǐng)域備受關(guān)注的重要靶點。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，適用于生命科學(xué)領(lǐng)域研究PCDH10在生理病理過程中的表達調(diào)控機制，例如探究其在神經(jīng)退行性疾病模型中的動態(tài)變化、腫瘤組織與正常組織的差異表達，或評估特定干預(yù)措施對PCDH10蛋白水平的影響本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    DKFZp761O2023 ELISA Kit; KIAA1400 ELISA Kit; MGC133344 ELISA Kit; OL PCDH ELISA Kit; Ortholog of OL pcdh ELISA Kit; OTTHUMP00000220001 ELISA Kit; PCD10_HUMAN ELISA Kit; PCDH10 ELISA Kit; PCDH19 ELISA Kit; Protocadherin 10 ELISA Kit; Protocadherin-10 ELISA Kit
  • 縮寫：
    PCDH10
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Potential calcium-dependent cell-adhesion protein.
  • 基因功能參考文獻：
    1. PCDH10 hypermethylation were found in 54.2% (58/107) of DLBCL cases, but only 12.5% (1/8) in reactive lymph node/follicular hyperplasia. PMID: 29202805
    2. This study provides insights into the tumorigenesis and progression of hepatocellular carcinoma (HCC), and puts forward the novel hypothesis that PCDH10 could be a new biomarker for HCC, or that combined with other molecular markers could increase the specificity and sensitivity of diagnostic tests for HCC. Restoration of PCDH10 could be a valuable therapeutic target for HCC. PMID: 28498423
    3. we found that the malignant character of GISTs was initiated and amplified by PCDH10 in a process regulated by HOTAIR. In summary, our findings imply that PCDH10 and HOTAIR may be useful markers of disease progression and therapeutic targets. PMID: 27659532
    4. we found that long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion PMID: 26871474
    5. These findings suggest that Pcdh10 may influence subcellular actin cytoskeletal organization and axon-axon interactions in the course of familial amyloidotic polyneuropathy PMID: 27338109
    6. PCDH10 methylation in serum is a potential prognostic biomarker for prostate cancer. PMID: 26881880
    7. Study found that hypermethylation of CpG probes in the promoter regions of HOXA9 and PCDH10 was associated with mature B-cell neoplasms. PMID: 26679037
    8. Data show that protocadherin 10 (PCDH10) over-expression could significantly induce cell apoptosis, and restrain proliferation, invasion and migration ability of BXPC-3 pancreatic cancer cells. PMID: 26927373
    9. Our present findings suggested that the hypermethylated CpG site counts of PCDH10 DNA promoter for evaluating the prognosis of GC was reasonable by using the D-BGS PMID: 26406945
    10. PCDH10 methylation is a potential biomarker that predicts a poor prognosis after curative resection of pathological stage I non-small-cell lung cancer. PMID: 26276761
    11. PCDH10 antagonized MM cell proliferation via the downregulation of Wnt/beta-catenin/BCL-9 signaling, whereas PCDH10 repressed the expression of AKT to promote the expression of GSK3beta and then to restrain the activation of beta-catenin PMID: 26081897
    12. These results suggest an important role of p53 in regulating tumor cell migration through activating PCDH10 expression. PMID: 25590240
    13. Aberrant methylation of PCDH10 predicts worse biochemical recurrence-free survival in patients with prostate cancer after radical prostatectomy. PMID: 25086586
    14. Gastric cancer patients with 5 or more methylated CpG sites of PCDH10 promoter had significantly poorer survival. PMID: 25260683
    15. Findings establish a novel PCDH10-Wnt/beta-catenin-MALAT1 regulatory axis that contributes to EEC development. PMID: 25085246
    16. These results indicate that promoter methylation status of PCDH10, SPARC, and UCHL1 may be used both as prognostic and predictive molecular marker for colorectal cancer patients PMID: 24309322
    17. Loss of PCDH10 expression is associated with metastasis in colorectal cancer. PMID: 24740680
    18. suppression of the expression of PCDH10 by RNA interference induces the growth arrest and apoptosis of glioblastoma cells in vitro PMID: 24406169
    19. study suggests that PCDH10 methylation occurs early in lymphomagenesis. PCDH10 expression was down regulated via promoter hypermethylation in T- and B-cell lymphoma cell lines PMID: 23929756
    20. The expression of PCDH10 was silenced in hepatocellular carcinoma via de novo DNA methylation. PMID: 22543497
    21. There was a significant correlation between PCDH10 methylation in cfDNA and tumour tissue in patients with early CRC. PMID: 23839493
    22. PCDH10 promoter methylation was detected in 59/117 (50.4%) of patients with bladder cancer, and none of 37 (0%) controls. Methylation was significantly associated with advanced stage, high grade, tumour recurrence and larger tumour size. PMID: 23321168
    23. Downregulated PCDH10 levels correlated with malignant behaviour and poor overall survival in patients with bladder cancer. PMID: 23569128
    24. PCDH10 methylation is closely associated with malignancy of bladder transitional cell carcinoma PMID: 23171734
    25. PCDH10 is frequently downregulated by promoter methylation and may serve as a tumor suppressor gene in non-small cell lung cancer. PMID: 23321465
    26. PCDH10 is an important tumor suppression gene with key roles of suppressing cell proliferation, clonogenicity, and inhibiting cell invasion in the development of colorectal cancer. PMID: 23180019
    27. PCDH10 gene is a target for epigenetic silencing in multiple myeloma and provides a link between the dysregulation of angiogenesis and DNA methylation. PMID: 22245948
    28. Data show that expression of PCDH10 is markedly reduced in gastric cancer cells and tissues, and suggest that it functions as a tumor suppressor gene in gastric cancer. PMID: 22206871
    29. PCDH10 promoter hypermethylation was frequent in both B-cell (81.9%) and T-cell (80%) acute lymphoblastic leukemia (ALL). PMID: 21960365
    30. genetic and epigenetic deregulation of PCDH10 occurs in a significant portion of medulloblastoma patients PMID: 21597995
    31. The decreased PCDH10 expression in prostate cancer cells was associated with the aberrant methylation of PCDH10 promoter CpG islands. PMID: 21314642
    32. Sp1/Sp3 and CBF/NF-Y transcription factors play a crucial role in the basal expression of the human PCDH10 gene. PMID: 21237250
    33. epigenetic regulation of PCDH10 was associated with carcinogenesis. PMID: 20353276
    34. Showed aberrant promoter hypermethylation of PCDH10 is assoc'd with downreg'n of gene expression in cervical cancer, and the promoter methylation in the PCDH10 gene occurs at an earliest identifiable stage of low-grade squamous intraepithelial lesion. PMID: 19681120
    35. Ectopic expression of PCDH10 strongly suppressed tumor cell growth, migration, invasion and colony formation. PMID: 16247458
    36. These results suggest that OL-pc remodels the motility and adhesion machinery at cell junctions by recruiting the Nap1-WAVE1 complex to these sites and, in turn, promotes the migration of cells. PMID: 18644894
    37. PCDH10 is a gastric tumor suppressor; its methylation at early stages of gastric carcinogenesis is an independent prognostic factor. PMID: 19084528
    38. The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation. PMID: 19262141
    39. field methylation of the PCDH10 gene specifically in the invasion stage of cervical carcinogenesis, which might be used to develop a highly specific diagnostic test for cervical scrapings. PMID: 19709077

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Moderately expressed in all regions of the brain examined, as well as in testis and ovary, and low expression in all other tissues tested.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13404

    OMIM: 608286

    KEGG: hsa:57575

    STRING: 9606.ENSP00000264360

    UniGene: Hs.192859