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  4. Human Receptor-type tyrosine-protein phosphatase zeta(PTPRZ1) ELISA kit

Human Receptor-type tyrosine-protein phosphatase zeta(PTPRZ1) ELISA kit

  • 中文名稱：
    人受體型蛋白酪氨酸磷酸酶ζ(PTPRZ1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL019068HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人受體型蛋白酪氨酸磷酸酶ζ(PTPRZ1)酶聯(lián)免疫試劑盒（CSB-EL019068HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的PTPRZ1含量。PTPRZ1 是一種蛋白質酪氨酸磷酸酶，在神經系統(tǒng)發(fā)育等過程有重要作用。研究機制方面，它參與細胞信號轉導，影響細胞增殖、分化等。異常表達或功能失調與神經系統(tǒng)疾病、腫瘤等多種病癥相關，是潛在的疾病治療靶點。試劑盒檢測范圍為93.75 pg/mL-6000 pg/mL，適用于基礎科研中探索PTPRZ1在神經系統(tǒng)疾病或腫瘤微環(huán)境中的作用機制、評估疾病模型動物體內靶標表達水平變化，或結合其他分子標志物進行生物樣本中PTPRZ1的定量分析，為分子病理學及信號通路研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    3F8 chondroitin sulfate proteoglycan ELISA Kit; 3H1 keratan sulfate proteoglycan ELISA Kit; HPTPZ ELISA Kit; HPTPzeta ELISA Kit; Phosphacan ELISA Kit; Protein tyrosine phosphatase receptor type Z polypeptide 2 ELISA Kit; Protein tyrosine phosphatase, receptor type, Z polypeptide 1 ELISA Kit; Protein tyrosine phosphatase, receptor type, zeta polypeptide 1 ELISA Kit; Protein-tyrosine phosphatase receptor type Z polypeptide 1 ELISA Kit; Protein-tyrosine phosphatase receptor type Z polypeptide 2 ELISA Kit; PTP-ZETA ELISA Kit; PTP18 ELISA Kit; PTPRZ ELISA Kit; PTPRZ_HUMAN ELISA Kit; Ptprz1 ELISA Kit; PTPZ ELISA Kit; R PTP zeta 2 ELISA Kit; R-PTP-zeta ELISA Kit; R-PTP-zeta-2 ELISA Kit; Receptor type tyrosine phosphatase beta/zeta ELISA Kit; Receptor-type tyrosine-protein phosphatase zeta ELISA Kit; RPTP-BETA ELISA Kit; RPTPB ELISA Kit; RPTPbeta ELISA Kit
  • 縮寫：
    PTPRZ1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    93.75 pg/mL-6000 pg/mL
  • 靈敏度：
    23.43 pg/ml
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human PTPRZ1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 97    
    Range % 92-101    
    1:2 Average % 91    
    Range % 85-96    
    1:4 Average % 103    
    Range % 98-106    
    1:8 Average % 87    
    Range % 82-93    
  • 回收率：
    The recovery of human PTPRZ1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 90 85-96    
    EDTA plasma (n=4) 102 98-105    
                   
                   
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    6000 1.755 1.812 1.784 1.649    
    3000 1.360 1.375 1.368 1.233    
    1500 0.974 0.955 0.965 0.830    
    750 0.589 0.545 0.567 0.432    
    375 0.450 0.436 0.443 0.308    
    187.5 0.335 0.352 0.344 0.209    
    93.75 0.226 0.236 0.231 0.096    
    0 0.137 0.133 0.135 　    
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades.
  • 基因功能參考文獻：
    1. Authors characterized exosomes from GBM cells harbouring and not harbouring PTPRZ1-MET fusion (ZM fusion). PMID: 28504721
    2. PTPRZ1 is affected in a contiguous gene deletion syndrome PMID: 23570448
    3. Confirm contribution of PTPRZ1, and especially PTPRQ, in CRC carcinogenesis and demonstrated that PTPRQ expression is correlated with KRAS mutation. PMID: 26851024
    4. Data indicate that enhanced MET oncoprotein RNA expression by fusion with receptor-type tyrosine-protein phosphatase zeta (PTPRZ1). PMID: 25935522
    5. Data indicate that the fusion arose from translocation events involving introns 3 or 8 of protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) and intron 1 of hepatocyte growth factor receptor MET. PMID: 25135958
    6. Distinct domains of PTPRZ-B are differentially required for migration and proliferation of glioma cells, respectively. PMID: 25238264
    7. Protein tyrosine phosphatase zeta enhances proliferation by increasing beta-catenin nuclear expression in VHL-inactive human renal cell carcinoma cells. PMID: 23588815
    8. Data suggest that CSF-1R-independent actions of IL-34 via receptor-type protein-tyrosine phosphatase zeta (PTP-zeta) might be considered in evaluating IL-34 roles in development and disease. PMID: 23744080
    9. PTPRZ1 was highly expressed in human neuroendocrine tumor tissues and PTPRZ1 is an oncogenic tyrosine phosphatase in small-cell lung carcinoma. PMID: 23170925
    10. Receptor-type Protein tyrosine phosphatase beta regulates met phosphorylation and function in head and neck squamous cell carcinoma. PMID: 23226095
    11. Studies indicate that RPTPzeta is an RPTP for which a link between ligand-dependent dimerization and inhibition of the intracellular tyrosine phosphatase activity has been clearly established. PMID: 22682003
    12. Enhanced RPTPbeta/zeta signaling can contribute to schizophrenia phenotypes and support both construct and face validity for PTPRZ1-transgenic mice as a model for multiple schizophrenia phenotypes. PMID: 22832403
    13. Loss of RPTPZ promotes prostate cancer metastasi. PMID: 23060448
    14. The results of this study suggested that pleiotrophin inhibition of PTPRZ1 contributes to the homeostatic self-renewal of OPCs and that this process is mediated by the tonic activation of beta-catenin/TCF-dependent transcription. PMID: 23100427
    15. report the cocrystal structure of the carbonic anhydrase-like domain of PTPRZ bound to tandem Ig repeats of CNTN1 and binding assays to show that PTPRZ binds specifically to CNTN1 expressed at the surface of oligodendrocyte precursor cells PMID: 21969550
    16. molecular basis for the substrate recognition of Ptprz. PMID: 21890632
    17. RPTP-beta is a key regulator of Met function. PMID: 21454675
    18. preferential activation of PTPRZ1 by HIF-2 results at least in part from cooperative binding of HIF-2 and ELK1 to nearby sites on the PTPRZ1 promoter region PMID: 20224786
    19. PTPRZ1 has a role in oligodendrocyte survival and in recovery from demyelinating disease PMID: 12355066
    20. RPTPzeta has a novel role in regulating glioblastoma cell motility PMID: 14555979
    21. In AZ-521 cells, which mainly express RPTPbeta, VacA, after binding to RPTPbeta in non-lipid raft microdomains on the cell surface, is localized with RPTPbeta in lipid rafts in a temperature- and VacA concentration-dependent process. PMID: 17030583
    22. Midkine, pleiotrophin (PTN), and their receptors syndecan-3 and receptor protein tyrosine phosphatase beta/zeta, were highly expressed in the striatum during developmen PMID: 17368428
    23. the PTN/RPTPbeta/zeta signaling pathway may be constitutively activated and potentially function to constitutively activate ALK in human breast cancer PMID: 17706593
    24. the effect of the shorter basic peptide P(122-131) on DU145 cells, which express HARP and its receptor RPTPB, suggested interference, under anchorage-independent conditions, of P(122-131) with a HARP autocrine loop in an RPTPB -dependent fashion. PMID: 17727841
    25. Pleiotrophin receptor (PTPRZ1) is expressed in embryonic stem cells and mediates important signals for survival, proliferation, and maintenance of pluripotency state. PMID: 17823238
    26. results from the immunohistochemical analyses of rPTPbeta/zeta expression should prompt further evaluation of this protein as a novel oligodendroglioma marker. PMID: 18003890
    27. PTPRZ1 is unlikely to be related to the development of schizophrenia in the Japanese population PMID: 18186075
    28. the cleavage sites in the extracellular juxtamembrane region of Ptprz by tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase 9. PMID: 18713734
    29. GnT-Vb-mediated glycosylation of RPTPbeta promotes galectin-1 binding and RPTPbeta levels of retention on the cell surface. PMID: 18838383
    30. these data suggest that alpha(v)beta(3) is a key molecule that determines the stimulatory or inhibitory effect of pleiotrophin on cell migration. PMID: 19141530
    31. phosphacan was present in the evolving astroglial scar after human traumatic spinal cord injury, and, therefore, might play an important role in the blockade of successful CNS regeneration. PMID: 19604403

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  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 5 subfamily
  • 組織特異性：
    Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
  • 數據庫鏈接：

    HGNC: 9685

    OMIM: 176891

    KEGG: hsa:5803

    STRING: 9606.ENSP00000377047

    UniGene: Hs.489824