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  4. Human Secretoglobin family 3A member 2(SCGB3A2) ELISA kit

Human Secretoglobin family 3A member 2(SCGB3A2) ELISA kit

  • 中文名稱：
    人分泌球蛋白3A成員2(SCGB3A2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL020819HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人分泌球蛋白3A成員2(SCGB3A2)酶聯(lián)免疫試劑盒（CSB-EL020819HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SCGB3A2含量。SCGB3A2是重要靶點。它是分泌蛋白，在呼吸道上皮細胞表達。研究發(fā)現(xiàn)其與肺部疾病如肺纖維化、哮喘等密切相關(guān)。機制上，它能調(diào)節(jié)炎癥反應、維持上皮細胞穩(wěn)態(tài)，針對其開發(fā)的藥物可干預相關(guān)疾病進程，有潛在治療價值。試劑盒檢測范圍為46.88 pg/mL-3000 pg/mL，本產(chǎn)品適用于基礎醫(yī)學研究中SCGB3A2蛋白表達動力學分析，如在呼吸道疾病模型中的功能探究、免疫調(diào)節(jié)機制研究或作為潛在生物標志物的篩選驗證，為探索其在肺部炎癥、過敏性疾病或腫瘤微環(huán)境中的作用提供可靠檢測工具，所有應用場景僅限于科研用途。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    LU103 ELISA Kit; Pneumo secretory protein 1 ELISA Kit; PnSP-1 ELISA Kit; PNSP1 ELISA Kit; SCGB3A2 ELISA Kit; Secretoglobin family 3A member 2 ELISA Kit; SG3A2_HUMAN ELISA Kit; UGRP1 ELISA Kit; Uteroglobin-related protein 1 ELISA Kit
  • 縮寫：
    SCGB3A2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    46.88 pg/mL-3000 pg/mL
  • 靈敏度：
    11.72 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Epigenetics and Nuclear Signaling
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human SCGB3A2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %95
    Range %91-98
    1:2Average %88
    Range %81-92
    1:4Average %104
    Range %98-111
    1:8Average %97
    Range %83-93
  • 回收率：
    The recovery of human SCGB3A2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9185-99
    EDTA plasma (n=4)9589-100
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    30002.703 2.752 2.728 2.606
    15001.906 1.866 1.886 1.764
    7501.128 1.200 1.164 1.042
    3750.545 0.539 0.542 0.420
    187.50.316 0.332 0.324 0.202
    93.750.205 0.208 0.207 0.085
    46.880.186 0.200 0.193 0.071
    00.121 0.122 0.122 　
    　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
  • 基因功能參考文獻：
    1. rs151333009 SNP showed a monomorphic genotype. Two promoter SNPs (rs6882292, -659 G/A and rs1368408, -112 G/A) showed significant association with asthma. These results suggest that the promoter SNPs (rs6882292 and rs1368408) of SCGB3A2 gene may contribute to susceptibility to asthma in a Korean population. PMID: 28422086
    2. This meta-analysis suggests that SCGB3A2 polymorphism at positions -112G>A was associated with Graves' disease both in Chinese and Caucasian population. PMID: 23934357
    3. the SCGB3A2 -112G >A polymorphism may be considered as a likely marker linking susceptibility to allergy/asthma and Graves' disease PMID: 21170691
    4. Reduced production of UGRP1, which is likely due, at least in part, to a local cytokine environment, may contribute to the hyper-inflammation in chronic rhinosinusitis and correlates with response to surgery. PMID: 21385388
    5. This study documents the association between polymorphisms in UGRP1 and the common cold, suggesting a potential role in its pathogenesis. PMID: 21410962
    6. Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID: 20466451
    7. pattern of UGRP-1 concentration resembled that of Clara cell protein, both proteins occurring in high concentrations in amniotic fluid, sputum and BALF and in much lower concentrations in serum and urine PMID: 20843168
    8. association was detected between SCGB3A2 and U.K. Caucasian Graves' disease subjects but the size of effect was smaller than that seen in the Oriental population (odds ratio = 1.28-1.73). PMID: 20210668
    9. polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma PMID: 11813133
    10. By in situ hybridization, UGRP1 is found to be expressed by lung Clara-like cells in the bronchial epithelium and up-regulated in lung epithelium of a patient with cystic fibrosis. PMID: 12847263
    11. results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID: 15485815
    12. plasma UGRP1 levels were associated with the G-112A UGRP1 gene promoter polymorphism and the severity of asthma PMID: 18089940
    13. results suggest that the -112G/A polymorphism does not play a significant role in the genetic predisposition of the UGRP1 gene in atopic asthma in the Sicilian population PMID: 18201431
    14. SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID: 19126779

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Secretoglobin family, UGRP subfamily
  • 組織特異性：
    Highly expressed in lung and trachea. Detected throughout the airway epithelium in lung, with slightly higher expression in large airways. Found in lung submucosal gland acinus where it localizes to serous-like cells. Probably expressed in club/Clara cell
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18391

    OMIM: 606531

    KEGG: hsa:117156

    STRING: 9606.ENSP00000296694

    UniGene: Hs.483765