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  4. Human Secretogranin-2(SCG2) ELISA kit

Human Secretogranin-2(SCG2) ELISA kit

  • 中文名稱：
    人分泌粒蛋白-2(SCG2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL020808HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人分泌粒蛋白-2(SCG2)酶聯(lián)免疫試劑盒（CSB-EL020808HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的SCG2含量。試劑盒檢測(cè)范圍為2.34 ng/ml- 150ng/ml，適用于神經(jīng)生物學(xué)、內(nèi)分泌學(xué)等領(lǐng)域的基礎(chǔ)研究，可用于探究SCG2在神經(jīng)退行性疾病模型、代謝調(diào)節(jié)機(jī)制或細(xì)胞分泌功能研究中的表達(dá)動(dòng)態(tài)，為體外實(shí)驗(yàn)樣本中靶蛋白的濃度測(cè)定提供可靠工具，滿足科研工作者對(duì)復(fù)雜生物樣本的定量分析需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說(shuō)明書。
  • 別名：
    CHGC ELISA Kit; Chromogranin C ELISA Kit; Chromogranin-C ELISA Kit; EM66 ELISA Kit; SCG2 ELISA Kit; SCG2_HUMAN ELISA Kit; Secretogranin II ELISA Kit; Secretogranin-2 ELISA Kit; Secretoneurin ELISA Kit; SGII ELISA Kit; SN ELISA Kit
  • 縮寫：
    SCG2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    2.34 ng/ml - 150ng/ml
  • 靈敏度：
    0.59 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 線性度：
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
  • 基因功能參考文獻(xiàn)：
    1. Differential Reovirus-Specific and Herpesvirus-Specific Activator Protein 1 Activation of Secretogranin II Leads to Altered Virus Secretion. PMID: 26378181
    2. present data show that SgII is highly expressed in advanced prostate cancer and may contribute to the neuroendocrine differentiation by promoting the formation of secretory granules and the proliferation of PCa cells. PMID: 25307750
    3. SN induces MUC5AC hypersecretion in a dose- and time-dependent manner; moreover, the MUC5AC over synthesis induced by SN is strongly associated with the enhanced binding of EGF to NRP1 PMID: 24556756
    4. Topical secretoneurin gene therapy accelerates diabetic wound healing by interaction between heparan-sulfate proteoglycans and basic FGF. PMID: 23918206
    5. Manserin may serve as a marker of prostate cancer progression. PMID: 21803620
    6. CgA, CgB, and secretoneurin are detectable in feces, and collagenous colitis patients express higher values than patients with inflammatory bowel disease and controls. In treatment, fecal secretoneurin decreased to control levels in collagenous colitis. PMID: 23423580
    7. In vivo secretoneurin improves left ventricular function, inhibits remodeling, and reduces scar formation; in the infarct border zone, secretoneurin induces coronary angiogenesis. PMID: 23081990
    8. Circulating Levels of SgII are Increased in Patients with chronic, stable heart failure. PMID: 22655045
    9. Data describe the gene expression and protein production of SgII in normal adrenal glands and pheochromocytomas with the goal to examine the molecular mechanisms leading to the marked variations in the expression of EM66 in tumoral chromaffin tissue. PMID: 22217803
    10. This short review deals with investigations in neuroendocrine tumors (NETs) with antibodies against defined epitopes of chromogranins (Cgs) A and B and secretogranins (Sgs) II and III. PMID: 21046454
    11. More SgII immunoreactive cells were observed in phaeochromocytomas. PMID: 20550951
    12. Transendothelial migration of leukocytes and signalling mechanisms in response to the neuropeptide secretoneurin. PMID: 11853870
    13. secretogranin II-derived peptide EM66 generated in human tumoral chromaffin tissue; significant difference in EM66 concentrations between benign and malignant pheochromocytomas PMID: 12788858
    14. the high concentration of secretoneurin in the aqueous humor indicates a significant role of this peptide PMID: 15572199
    15. a variant of Secretogranin II has a role in regulation by PHOX2 transcription factors and in hypertension PMID: 17584765
    16. Results suggest that secretogranin II represents a key AP-1-regulated protein that counteracts nitric oxide toxicity and mediates neuronal differentiation of neuroblastoma cells. PMID: 18239671
    17. Increased concentrations of SgII, especially the N-terminal part of secretoneurin could be measured in plasma from patients with endocrine pancreatic tumours. PMID: 18448176
    18. Suppression of Pdcd4 resulted in an increased release of CgA and Sg II and was accompanied by an up-regulation of intracellular PC1. PMID: 18549351
    19. semiquantitative immunocytochemistry for secretogranin II in amyotrophic lateral sclerosis. PMID: 18721831

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  • 亞細(xì)胞定位：
    Secreted. Note=Neuroendocrine and endocrine secretory granules.
  • 蛋白家族：
    Chromogranin/secretogranin protein family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10575

    OMIM: 118930

    KEGG: hsa:7857

    STRING: 9606.ENSP00000304133

    UniGene: Hs.516726