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  4. Human Semaphorin-3D(SEMA3D) ELISA kit

Human Semaphorin-3D(SEMA3D) ELISA kit

  • 中文名稱：
    人臂板蛋白-3D(SEMA3D)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL020983HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人臂板蛋白-3D(SEMA3D)酶聯(lián)免疫試劑盒（CSB-EL020983HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的SEMA3D含量。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，支持研究者開展神經(jīng)生物學(xué)機(jī)制探索、腫瘤血管生成研究或心血管疾病模型中SEMA3D的動(dòng)態(tài)變化分析，為體外檢測(cè)蛋白表達(dá)提供穩(wěn)定可靠的工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    Coll 2 ELISA Kit; Coll2 ELISA Kit; Collapsin 2 ELISA Kit; SEM3D_HUMAN ELISA Kit; Sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3D ELISA Kit; Sema Z2 ELISA Kit; Sema3d ELISA Kit; Semaphorin-3D ELISA Kit; Semaphorin3D ELISA Kit
  • 縮寫：
    SEMA3D
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin.
  • 基因功能參考文獻(xiàn)：
    1. Low SEMA3D expression is associated with colorectal cancer. PMID: 28320475
    2. Novel mutation in SEMA3D segregates with the complete phenotype with variable expressivity in two pedigrees with autosomal dominant familial Meniere's disease. PMID: 27876815
    3. Data show significant increases in semaphorin3C, 3D and their receptor neuropilin-2 in degenerate samples which were shown to contain nerves and blood vessels, compared to non-degenerate samples without nerves and blood vessels. PMID: 26286962
    4. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies PMID: 26073756
    5. Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability. PMID: 25839327
    6. Semaphorin 3d requires neuropilin 1 or PI3K/Akt, whereas semaphorin 3e requires plexin D1 in directing endothelial motility. PMID: 24825896
    7. In the absence of Sema3d, endothelial tubes form in a region that is normally avascular PMID: 23685842
    8. in this study we have analyzed three aminoacidic substitutions, A131T-SEMA3A, S598G-SEMA3A and E198K-SEMA3D. These variants result in an increase of SEMA proteins levels in the HSCR colon tissue. PMID: 23372769
    9. This study provided strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder. PMID: 20684831
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20684831
    11. Observational study of gene-disease association. (HuGE Navigator) PMID: 19054571
    12. Sema3D inhibits tumor development from MDA-MB-231 and MDA-MB-435 cancer cells. It inhibits tumor angiogenesis in all of the formed tumors. PMID: 18818766

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Semaphorin family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10726

    OMIM: 609907

    KEGG: hsa:223117

    STRING: 9606.ENSP00000284136

    UniGene: Hs.201340