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  4. Human Serglycin(SRGN) ELISA kit

Human Serglycin(SRGN) ELISA kit

  • 中文名稱：
    人絲甘蛋白聚糖(SRGN)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL022664HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人絲甘蛋白聚糖(SRGN)酶聯(lián)免疫試劑盒（CSB-EL022664HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的SRGN含量。SRGN即聚硫蛋白聚糖，在多種生理和病理過程中發(fā)揮作用。它參與細胞黏附、遷移等過程，還與炎癥反應相關(guān)。研究發(fā)現(xiàn)其在腫瘤微環(huán)境中可調(diào)節(jié)免疫細胞功能，影響腫瘤進展，目前是腫瘤及免疫相關(guān)研究中值得關(guān)注的靶點。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，適用于探索SRGN在免疫細胞功能研究、腫瘤微環(huán)境分析、炎癥性疾病模型構(gòu)建等科研場景中的表達特征與調(diào)控機制，為深入解析SRGN在疾病發(fā)生發(fā)展中的分子機制提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Chondroitin sulfate proteoglycan core protein ELISA Kit; Cytolytic granule proteoglycan core protein ELISA Kit; FLJ12930 ELISA Kit; gp600 ELISA Kit; Hematopoetic proteoglycan core protein ELISA Kit; Mastocytoma proteoglycan core protein ELISA Kit; MGC9289 ELISA Kit; OTTHUMP00000019716 ELISA Kit; P.PG ELISA Kit; PG19 core protein ELISA Kit; Pgsg ELISA Kit; Platelet proteoglycan core protein ELISA Kit; platelet proteoglycan protein core ELISA Kit; PLATELET PROTEOGLYCAN PROTEIN CORE; PPG ELISA Kit; PPG ELISA Kit; PRG ELISA Kit; PRG1 ELISA Kit; PROTEOGLYCAN 1 ELISA Kit; proteoglycan 1; secretory granule ELISA Kit; Proteoglycan 10K core protein ELISA Kit; Proteoglycan peptide core protein ELISA Kit; PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE ELISA Kit; secretory granule proteoglycan 1 ELISA Kit; Secretory granule proteoglycan core peptide ELISA Kit; Secretory granule proteoglycan core protein ELISA Kit; Serglycin ELISA Kit; serglycin proteoglycan ELISA Kit; Sgc ELISA Kit; Srgn ELISA Kit; SRGN_HUMAN ELISA Kit
  • 縮寫：
    SRGN
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human SRGN in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 107
    Range % 103-112
    1:2 Average % 97
    Range % 93-102
    1:4 Average % 94
    Range % 88-98
    1:8 Average % 96
    Range % 92-99
  • 回收率：
    The recovery of human SRGN spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 93 88-97
    EDTA plasma (n=4) 87 82-91
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    20 2.612 2.535 2.574 2.414
    10 2.265 2.171 2.218 2.058
    5 1.667 1.632 1.650 1.490
    2.5 1.078 1.064 1.071 0.911
    1.25 0.675 0.669 0.672 0.512
    0.625 0.443 0.438 0.441 0.281
    0.312 0.328 0.323 0.326 0.166
    0 0.161 0.159 0.160 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • 基因功能參考文獻：
    1. SRGN overexpression promoted colorectal cancer cell migration and invasion and SRGN was physically binding to a hypoxia response element in its promoter region. PMID: 30121667
    2. SRGN secreted by tumor cells and stromal components in the TME promotes malignant phenotypes through interacting with tumor cell receptor CD44 PMID: 27819672
    3. Extracellular spce serglycin upregulated CD44 receptor expression to maintain nasopharyngeal carcinoma stemness by interacting with CD44 and activating the MAPK/beta-catenin pathway. PMID: 27809309
    4. SRGN expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. Patients with NPC with tumors showing strong tumor intensity and low infiltrated percentage of tumor-infiltrated lymphocytes with serglycin may be at high risk for distant metastases. PMID: 24995621
    6. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression PMID: 26581653
    7. These results suggest functions for serglycin in endothelial cells trough interactions with partner molecules, in biological processes with relevance for diabetic complications, cardiovascular disease and cancer development. PMID: 26694746
    8. These results suggest that different signaling pathways are involved in regulating secretion of serglycin and partner molecules in activated endothelial cells. PMID: 24513305
    9. The reduced expression of SRGN was accompanied by elevated levels of E-cadherin. PMID: 23996242
    10. These studies provide direct evidence for a critical role for serglycin in MM pathogenesis and show that targeting serglycin may provide a novel therapeutic approach for MM. PMID: 24403068
    11. These results suggest that human epicardial adipose tissue (EAT) has strong inflammatory properties in patients with coronary artery disease and provide novel evidence that serglycin is an adipocytokine highly expressed in EAT. PMID: 23376071
    12. Cell-surface SRGN promotes the adhesion of myeloma cells to collagen type I. PMID: 23387827
    13. This review covers recent studies on the involvement of serglycin in various pathological conditions, as well as its roles in immunity, hemostasis, cell growth, apoptosis, and reproduction. PMID: 22807344
    14. Human granulocyte precursors transfected with siRNA against serglycin displayed reduced capability to retain fully processed HNP-1. PMID: 21849484
    15. Serglycin regulates NPC metastasis via autocrine and paracrine routes, and that it serves as an independent prognostic indicator of metastasis-free survival and disease-free survival in NPC patients. PMID: 21289131
    16. Serglycin secreted by human multiple myeloma cell lines inhibits both the classical and lectin pathways of complement, without influencing alternative pathway activity. PMID: 21268013
    17. Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. PMID: 21075844
    18. proapoptotic granzyme is exocytosed predominantly as a macromolecular complex with serglycin PMID: 12388539
    19. cell- and differentiation-specific alterations in chromatin structure may control serglycin gene expression PMID: 14506241
    20. serglycin-bound granzyme B in high-molecular-weight degranulate material from cytotoxic T lymphocytes predominantly followed a dynamin-dependent pathway to kill target cells PMID: 14739229
    21. mechanism of delivery is proposed entailing electrostatic transfer of granzyme B from serglycin to cell surface proteins PMID: 15788411
    22. Serglycin release is a constitutive process, which may be of fundamental biological importance in the study of multiple myeloma. PMID: 16870619
    23. Serglycin is of importance for secretory processes in human monocytes. PMID: 17909965
    24. Mutations in SRGN is not associated with familial hemophagocytic lymphohistiocytosis PMID: 18000860

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  • 亞細胞定位：
    Cytoplasmic granule. Cytolytic granule. Secreted, extracellular space. Golgi apparatus.
  • 蛋白家族：
    Serglycin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9361

    OMIM: 177040

    KEGG: hsa:5552

    STRING: 9606.ENSP00000242465

    UniGene: Hs.1908