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  4. Human Slit homolog 3 protein(SLIT3) ELISA kit

Human Slit homolog 3 protein(SLIT3) ELISA kit

  • 中文名稱：
    人Slit同源蛋白3(SLIT3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL021769HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人Slit同源蛋白3(SLIT3)酶聯(lián)免疫試劑盒（CSB-EL021769HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液樣本中的SLIT3含量。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，科研人員可將其應(yīng)用于體外細(xì)胞模型中SLIT3分泌動(dòng)態(tài)監(jiān)測、疾病動(dòng)物模型血清標(biāo)志物研究，或探索特定病理狀態(tài)下SLIT3與細(xì)胞信號通路的關(guān)聯(lián)機(jī)制，為神經(jīng)生物學(xué)、腫瘤學(xué)及血管相關(guān)疾病的基礎(chǔ)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    FLJ10764 ELISA Kit; KIAA0814 ELISA Kit; MEGF 5 ELISA Kit; MEGF5 ELISA Kit; Multiple EGF-like domains protein 5 ELISA Kit; Multiple epidermal growth factor like domains 5 ELISA Kit; Multiple epidermal growth factor-like domains protein 5 ELISA Kit; SLIL 2 ELISA Kit; SLIL2 ELISA Kit; SLIT 1 ELISA Kit; Slit 2 ELISA Kit; Slit 3 ELISA Kit; Slit homolog 3 (Drosophila) ELISA Kit; Slit homolog 3 ELISA Kit; Slit homolog 3 protein ELISA Kit; Slit-3 ELISA Kit; SLIT1 ELISA Kit; Slit2 ELISA Kit; Slit3 ELISA Kit; SLIT3_HUMAN ELISA Kit
  • 縮寫：
    SLIT3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human SLIT3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 93    
    Range % 90-97    
    1:2 Average % 85    
    Range % 82-93    
    1:4 Average % 110    
    Range % 105-115    
    1:8 Average % 106    
    Range % 102-117    
  • 回收率：
    The recovery of human SLIT3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 90 86-95    
    EDTA plasma (n=4) 99 95-102    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    ng/ml OD1 OD2 Average Corrected    
    10 1.866 1.955 1.911 1.777    
    5 1.472 1.588 1.530 1.396    
    2.5 1.162 1.201 1.182 1.048    
    1.25 0.864 0.873 0.869 0.735    
    0.625 0.525 0.558 0.542 0.408    
    0.312 0.312 0.313 0.313 0.179    
    0.156 0.267 0.276 0.272 0.138    
    0 0.137 0.131 0.134 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of Slit3 induces its tumor suppressive effects in Breast cancer. PMID: 26542734
    2. Results show that silencing of Slit3 promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 functions as a tumor suppressor in lung carcinoma. PMID: 26045181
    3. Estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions. PMID: 25051436
    4. SLIT3 is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 in these tissues. PMID: 24286238
    5. High SLIT3 expression is associated with high-grade gliomas. PMID: 24158112
    6. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. PMID: 24090675
    7. results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation PMID: 23720784
    8. Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo. PMID: 22614124
    9. SLIT3 duplication on 5q35.1 predisposes to major depressive disorder PMID: 21152026
    10. The chemorepellent Slit3 promotes monocyte migration. PMID: 21078908
    11. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
    12. Many variants in SLIT3 tend to associate with schizophrenia susceptibility in the Chinese Han population. PMID: 15231749
    13. data suggest that Slit proteins play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit PMID: 16162649
    14. In fetal and embryonic stem cell cultures Slit-3 inhibited neurite outgrowth. PMID: 16840550
    15. functions to promote angiogenesis in coordinating organogenesis during embryonic development PMID: 19741192

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  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Predominantly expressed in thyroid.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11087

    OMIM: 603745

    KEGG: hsa:6586

    STRING: 9606.ENSP00000430333

    UniGene: Hs.552087