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  4. Human Stanniocalcin-2(STC2) ELISA kit

Human Stanniocalcin-2(STC2) ELISA kit

  • 中文名稱：
    人斯鈣素-2(STC2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL022822HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人斯鈣素-2(STC2)酶聯(lián)免疫試劑盒（CSB-EL022822HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的STC2含量。人斯鈣素-2（STC2）是一種糖蛋白，廣泛表達(dá)于多種腫瘤細(xì)胞和組織中。其表達(dá)受多種應(yīng)激條件調(diào)控，有助于細(xì)胞應(yīng)對(duì)應(yīng)激狀態(tài)，防止細(xì)胞凋亡。STC2過表達(dá)與腫瘤生長(zhǎng)、侵襲、轉(zhuǎn)移及患者預(yù)后相關(guān)，被視為一種通用腫瘤生物標(biāo)志物和潛在治療靶點(diǎn)。試劑盒檢測(cè)范圍為31.2 pg/mL-2000 pg/mL，適用于體外實(shí)驗(yàn)中對(duì)STC2表達(dá)水平的動(dòng)態(tài)監(jiān)測(cè)，如腫瘤微環(huán)境分析、代謝相關(guān)信號(hào)通路研究、細(xì)胞應(yīng)激模型構(gòu)建等基礎(chǔ)科研領(lǐng)域，為探索STC2在疾病發(fā)生發(fā)展中的功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Stanniocalcin 2 ELISA Kit; Stanniocalcin related protein ELISA Kit; Stanniocalcin-2 ELISA Kit; Stanniocalcin-related protein ELISA Kit; Stanniocalcin2 ELISA Kit; STC 2 ELISA Kit; STC related protein ELISA Kit; STC-2 ELISA Kit; STC-related protein ELISA Kit; STC2 ELISA Kit; STC2_HUMAN ELISA Kit; STCRP ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測(cè)范圍：
    31.2 pg/mL-2000 pg/mL
  • 靈敏度：
    7.8 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human STC2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 87
    Range % 82-91
    1:2 Average % 94
    Range % 89-98
    1:4 Average % 107
    Range % 103-110
    1:8 Average % 110
    Range % 104-114
  • 回收率：
    The recovery of human STC2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 95 91-99
    EDTA plasma (n=4) 103 98-108
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2000 2.096 2.103 2.100 1.982
    1000 1.641 1.598 1.620 1.502
    500 1.105 1.201 1.153 1.035
    250 0.666 0.672 0.669 0.551
    125 0.434 0.442 0.438 0.320
    62.5 0.268 0.256 0.262 0.144
    31.25 0.211 0.201 0.206 0.088
    0 0.116 0.120 0.118 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Has an anti-hypocalcemic action on calcium and phosphate homeostasis.
  • 基因功能參考文獻(xiàn)：
    1. MiR-184 was confirmed to directly target STC2 in glioblastoma cells PMID: 28887636
    2. Results show that STC2 promotes head and neck squamous cell carcinoma cell proliferation, tumor growth, and metastasis through the PI3K/AKT/Snail pathway. PMID: 27863406
    3. STC2 promotes colorectal cancer tumorigenesis and epithelial-mesenchymal transition (EMT) progression through activating ERK/MEK and PI3K/AKT signaling pathways. PMID: 27662663
    4. Our results demonstrated the contrasting effects of STC1 and STC2-derived peptides on human macrophage foam cell formation associated with ACAT1 expression and on HASMC migration. PMID: 27346255
    5. Mus81 knockdown suppresses proliferation and survival of HCC cells likely by downregulating STC2 expression, implicating Mus81 as a therapeutic target for HCC. PMID: 27939696
    6. These findings indicated that STC2 may promote osteoblast differentiation and mineralization by regulating ERK activation PMID: 27878259
    7. STC2 is involved in regulating PAPP-A activity during the development of atherosclerosis PMID: 26983002
    8. Data suggest that stanniocalcin 1 and 2 (STC1, STC2) participate in inhibition of proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) during folliculogenesis. PMID: 26874357
    9. Up-regulation of CDK2 and CDK4 and down-regulation of cell cycle inhibitors p16 and p21 were observed after the delivery of STC2. Furthermore, STC2 transduction activated pAKT and pERK 1/2 signal pathways. PMID: 26424558
    10. This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance. PMID: 25771305
    11. STC2 may inhibit epithelial-mesenchymal transition at least partially through the PKC/Claudin-1-mediated signaling in human breast cancer cells. PMID: 25830567
    12. STC2 has a role in promoting cell proliferation and cisplatin resistance in cervical cancer PMID: 26361149
    13. The aim of this study was to evaluate the clinical value of measuring expression levels of STC2 in colorectal cancer (CRC) patients. PMID: 25234931
    14. Stanniocalcin 2 may contribute to tumor development and radioresistance in cervical cancer. PMID: 25674244
    15. These findings suggest that STC2 can be a potential lung cancer biomarker and plays a positive role in lung cancer metastasis and progression. PMID: 25463045
    16. Circulating STC1 and STC2 mRNA are potentially useful blood markers for LSCC PMID: 24743310
    17. High STC2 expression is associated with glioma. PMID: 24729417
    18. Interleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression. PMID: 24503185
    19. STC2 overexpression correlates to poor prognosis for nasopharyngeal carcinomas. PMID: 24606961
    20. stanniocalcin 2 (STC2) was the most highly upregulated gene in anti-VEGF antibody-treated tumors PMID: 24375080
    21. Our results indicate that STC2 could be a useful molecular blood marker for predicting tumor progression by monitoring CTCs in patients with gastric cancer. PMID: 24100594
    22. Stanniocalcin-1 and -2 promote angiogenic sprouting in HUVECs via VEGF/VEGFR2 and angiopoietin signaling pathways. PMID: 23664860
    23. High STC2 expression levels are associated with disease recurrence in patients with gastric cancer. PMID: 23548070
    24. High STC2 expression is associated with lymph node metastasis in squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. PMID: 23906305
    25. STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration. PMID: 23187001
    26. These findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme. PMID: 22503972
    27. High STC2 is associated with lymph node metastases in squamous cell esophageal carcinoma. PMID: 20734150
    28. Human stanniocalcin-1 or -2 expressed in mice reduces bone size and severely inhibits cranial intramembranous bone growth. PMID: 20174869
    29. High expression level of Stanniocalcin 2 is associated with gastric cancer. PMID: 20422456
    30. STC2 is a positive regulator in tumor progression at hypoxia. PMID: 20619259
    31. STC2 is a HIF-1 target gene and is involved in the regulation of cell proliferation. PMID: 19786016
    32. STC-2 can act as a potent growth inhibitor and reduce intramembranous and endochondral bone development and skeletal muscle growth, implying that these tissues are specific physiological targets of stanniocalcins PMID: 15367391
    33. Recombinant human and fish STC2 proteins were generated and found to be N-glycosylated homodimers. STC2 is a functional homodimeric glycoprotein, and thecal cell-derived STC2 could play a paracrine role during follicular development. PMID: 15486227
    34. NTN4, TRA1, and STC2 have roles in progression of breast cancer PMID: 17545519
    35. The induction of GDF15 and STC2 is likely specific to MK-4, vitamin K2 analog. PMID: 17909264
    36. elevated expression of STC-1 or STC-2 act as survival factors also for breast cancer cells and thereby contribute to tumor dormancy. PMID: 18355956
    37. STC2 was aberrantly hypermethylated in human cancer cells. PMID: 18394600
    38. Stanniocalcin 2 expression is regulated by hormone signalling and negatively affects breast cancer cell viability in vitro. PMID: 18492817
    39. stanniocalcin 2 overexpression in a prostate cancer cell line promoted prostate cancer cell growth, indicating its oncogenic property PMID: 19298603
    40. Increased STC2 gene expression is associated with colorectal cancer. PMID: 19415750
    41. Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma. PMID: 19582875

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Stanniocalcin family
  • 組織特異性：
    Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11374

    OMIM: 603665

    KEGG: hsa:8614

    STRING: 9606.ENSP00000265087

    UniGene: Hs.233160