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  4. Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

  • 中文名稱：
    人T細(xì)胞免疫球蛋白及粘蛋白域包含蛋白4(TIMD4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL023546HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人T細(xì)胞免疫球蛋白及粘蛋白域包含蛋白4(TIMD4)酶聯(lián)免疫試劑盒（CSB-EL023546HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的TIMD4含量。TIMD4，又稱TIM-4，是一種膜蛋白，作為磷脂酰絲氨酸受體，在免疫應(yīng)答中發(fā)揮作用，如凋亡細(xì)胞的吞噬和T細(xì)胞調(diào)節(jié)。TIMD4通過雙模式控制T細(xì)胞活化，并促進(jìn)對(duì)凋亡細(xì)胞或外源顆粒的吞噬，對(duì)T細(xì)胞活化和免疫反應(yīng)至關(guān)重要。試劑盒檢測(cè)范圍為0.156 ng/mL-10 ng/mL，適用于科研領(lǐng)域中對(duì)免疫細(xì)胞功能調(diào)控機(jī)制、感染性疾病免疫應(yīng)答、腫瘤免疫逃逸等方向的研究，為探索TIMD4在病理生理過程中的分子機(jī)制提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    SMUCKLER ELISA Kit; Spleen; mucin-containing; knockout of lymphotoxin protein ELISA Kit; T cell immunoglobulin and mucin domain containing protein 4 ELISA Kit; T-cell immunoglobulin and mucin domain containing 4 ELISA Kit; T-cell immunoglobulin and mucin domain containing molecule ELISA Kit; T-cell immunoglobulin and mucin domain-containing protein 4 ELISA Kit; T-cell immunoglobulin and mucin domains-containing protein 4 ELISA Kit; T-cell membrane protein 4 ELISA Kit; TIM-4 ELISA Kit; Tim4 ELISA Kit; TIMD 4 ELISA Kit; TIMD-4 ELISA Kit; Timd4 ELISA Kit; TIMD4_HUMAN ELISA Kit
  • 縮寫：
    TIMD4
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TIMD4 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %98
    Range %93-102
    1:2Average %99
    Range %92-102
    1:4Average %88
    Range %82-91
    1:8Average %95
    Range %91-99
  • 回收率：
    The recovery of human TIMD4 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9182-94
    EDTA plasma (n=4)10094-104
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    102.517 2.476 2.497 2.351
    51.583 1.543 1.563 1.417
    2.50.951 1.005 0.978 0.832
    1.250.602 0.637 0.620 0.474
    0.6250.481 0.466 0.474 0.328
    0.3120.291 0.304 0.298 0.152
    0.1560.212 0.217 0.215 0.069
    00.148 0.144 0.146
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1.
  • 基因功能參考文獻(xiàn)：
    1. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for coronary heart disease and ischemic stroke PMID: 29208769
    2. High expression of TIMD4 in clear cell renal cancer cells was closely related to short progression free survival time, and was associated with resistance to sorafenib. PMID: 28631038
    3. VitD deficiency may contribute to the pathogenesis of allergic rhinitis (AR) by increasing the TIM4 expression. The results suggest that to regulate the serum calcitriol levels and the expression of VDR in DCs may be necessary to be taken into account in the treatment of AR. PMID: 28160341
    4. This study aimed to investigate the association of two TIM-4 SNPs) with systemic lupus erythematosus (SLE)susceptibility in a Chinese Han population.The results imply that GG genotype of the TIM-4 gene at -1419 site might be associated with the disease activity of SLE. PMID: 28371471
    5. Role of TIM-4 in exosome-dependent entry of HIV-1 into human immune cells PMID: 28740388
    6. analysis of the molecular characteristics of both mTIM-4 and hTIM-4 provides a better understanding of the regions of the TIM-4 IgV domain critical for Ebola virus entry PMID: 27122575
    7. Tim-4 expression is closely associated with glioma and may have a regulatory role PMID: 26741116
    8. Data indicate that T cell immunoglobulin and mucin domain containing 4 (TIM-4) contributes, at least in part, to the pathogenesis of type 2 diabetes mellitus (T2D), possibly by regulating interleukin-1beta (IL-1beta). PMID: 25676395
    9. TIM4 binds TIM3 on the surface of polarized Th1 cells to induce Th1 cell apoptosis, which may contribute to the development of Th2-dominant immune disorders. PMID: 26403707
    10. TIM-4 rs7700944 and not TIM-1 rs41297579 G>A (-1454) is associated with rheumatoid arthritis(RA) in the present cohort of Egyptian and may be a risk factor for development of RA in Egyptian. PMID: 25899833
    11. Data showed up-regulation of TIM-4 in lung cancer tissues and a correlation with poor prognosis. Also, TIM-4 was found to promote growth of lung cancer cells by its interaction with integrin alphavbeta3 through its RGD motif. PMID: 26512878
    12. Tim-4 expression on monocytes and Tim-4 level in plasma were more highly increased in ankylosing spondylitis patients than in controls. PMID: 25359708
    13. Our results do not support an association between the rs7700944 polymorphism of the TIM-4 gene and rheumatoid arthritis PMID: 24217665
    14. Data suggest that genetic polymorphisms in ANGPTL3 (angiopoietin-like 3 protein), TIMD4 (T cell immunoglobulin mucin-4), and apolipoproteins A5 and B are among the genetic determinants of hypertriglyceridemia in Amerindian populations. [REVIEW] PMID: 24768220
    15. TIM4 expression is promoted by Cockroach allergen Bla g 7 in dendritic cells leading to Th2 polarization PMID: 24204099
    16. TIM-1 and TIM-4 are novel targets for ADAM10- and ADAM17-mediated ectodomain shedding. PMID: 24286866
    17. FG-CC' siRNA blocking interaction of Tim-1 and Tim-4 can enhance dendritic cell vaccine activity against gastric cancer. PMID: 22709877
    18. There were four SNPs in the promoter region of TIM4 in asthma patients of Chinese Han population, which were in linkage disequilibrium. PMID: 18704309
    19. TIM-4 variant or a highly correlated nearby gene of the TIM-4 gene may play a critical role in the pathogenesis of rheumatoid arthritis in many ethnicities. PMID: 22353209
    20. macrophage-derived TIM4 plays an important role in the induction of Tregs in gliomas, which may play an important role in tumor tolerance. PMID: 21896488
    21. TIM-4 gene polymorphisms are associated with asthma in a Chinese Han population. PMID: 20727045
    22. Overexpression of TIM-4 on antigen- presenting cells in transgenic mice reduces the number of antigen-specific T cells that remain after immunization, resulting in reduced secondary T cell responses. PMID: 21037090
    23. results showed that Tim-4 mRNA expression in peripheral blood mononuclear cells was significantly higher in system lupus erythematosus patients than in healthy controls, especially those patients in the active phase of disease. PMID: 20140011
    24. The polymorphism of 8570G > A in TIM4 may be associated with allergic asthma in the population of Han nationality from Hubei province of China. PMID: 17407086
    25. The results demonstrate that Staphylococcus aureus derived Staphylococcal enterotoxin B promotes the TIM4 production in human dendritic cells. PMID: 17439824
    26. TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity. PMID: 18082433
    27. Structures of T cell immunoglobulin mucin protein 4 show a metal-Ion-dependent ligand binding site where phosphatidylserine binds. PMID: 18083575
    28. Data show that the transmembrane region and cytoplasmic tail of TIM-4 are dispensable for apoptotic cell engulfment, and suggest that TIM-4 is a PtdSer tethering receptor without any direct signaling of its own. PMID: 19217291
    29. TIM4 -1419G>A polymorphism might be the genetic factor for the risk of childhood asthma in Chinese Han population. PMID: 19392790

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, TIM family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25132

    OMIM: 610096

    KEGG: hsa:91937

    STRING: 9606.ENSP00000274532

    UniGene: Hs.334907