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  4. Human Thioredoxin domain-containing protein 5(TXNDC5) ELISA kit

Human Thioredoxin domain-containing protein 5(TXNDC5) ELISA kit

  • 中文名稱：
    人含硫氧還蛋白結構域蛋白5(TXNDC5)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL025379HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人含硫氧還蛋白結構域蛋白5(TXNDC5)酶聯(lián)免疫試劑盒（CSB-EL025379HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的TXNDC5含量。TXNDC5是一種位于內(nèi)質(zhì)網(wǎng)腔內(nèi)的蛋白質(zhì)二硫鍵異構酶，對蛋白質(zhì)穩(wěn)定性和功能至關重要。其研究機制涉及催化二硫鍵重排、減少異常蛋白質(zhì)合成，具有抗氧化、抑制細胞凋亡等作用。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，靈敏度為0.039 ng/mL?？蔀榭蒲腥藛T探索TXNDC5在代謝性疾病、炎癥反應或癌癥發(fā)生發(fā)展中的分子機制提供可靠工具，亦可用于評估藥物干預或基因修飾對TXNDC5表達水平的影響，為相關基礎研究與生物標志物篩選提供數(shù)據(jù)支持本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    EndoPDI ELISA Kit; Endoplasmic reticulum protein ERp46 ELISA Kit; Endoplasmic reticulum resident protein 46 ELISA Kit; Endothelial protein disulphide isomerase ELISA Kit; ER protein 46 ELISA Kit; ERp46 ELISA Kit; Hcc 2 ELISA Kit; MGC3178 ELISA Kit; PDIA15 ELISA Kit; Protein disulfide isomerase family A member 15 ELISA Kit; STRF8 ELISA Kit; Thioredoxin domain containing 5 (endoplasmic reticulum) ELISA Kit; Thioredoxin domain containing 5 ELISA Kit; Thioredoxin domain containing protein 5 ELISA Kit; Thioredoxin domain-containing protein 5 ELISA Kit; Thioredoxin like protein p46 ELISA Kit; Thioredoxin related protein ELISA Kit; Thioredoxin-like protein p46 ELISA Kit; TLP46 ELISA Kit; TXND5_HUMAN ELISA Kit; TXNDC 5 ELISA Kit; Txndc5 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human TXNDC5 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:5

    Average %

    90

    Range %

    87-94

    1:10

    Average %

    90

    Range %

    85-94

    1:20

    Average %

    88

    Range %

    80-96

    1:40

    Average %

    92

    Range %

    86-99

  • 回收率：

    The recovery of human TXNDC5 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    97

    89-104

    EDTA plasma (n=4)

    94

    90-98

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    10

    2.286

    2.186

    2.236

    2.083

    5

    1.752

    1.652

    1.702

    1.549

    2.5

    1.193

    1.153

    1.173

    1.020

    1.25

    0.704

    0.694

    0.699

    0.546

    0.625

    0.441

    0.431

    0.436

    0.283

    0.312

    0.311

    0.301

    0.306

    0.153

    0.156

    0.236

    0.226

    0.231

    0.078

    0

    0.153

    0.152

    0.153

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.
  • 基因功能參考文獻：
    1. Hypoxia induces the expression of TXNDC5 via upregulating HIF-1alpha in colorectal cancer cells. PMID: 29749460
    2. TXNDC5 is also closely associated with rheumatoid arthritis, diabetes, hepatic steatosis and vitiligo. [review] PMID: 28604976
    3. High TXNDC5 expression is associated with renal cell carcinoma. PMID: 26810069
    4. we defined an important role of TXNDC5 in CRPC and further investigations are needed to screen TXNDC5 antagonists as a novel therapeutic approaches to treat PCa patients with Castration-resistant prostate cancer. PMID: 25500540
    5. Role of ERp46 in oxidative protein folding.Independent actions of ERp46 thioredoxin domains on folding substrates.Structure of thioredoxin ERp46 domains. PMID: 24462249
    6. suggest that the tumorigenic properties of ERp46 in RCC cells are not related to an inhibitory modulation of AdipoR1 PMID: 24594673
    7. Endo-PDI is a novel, important mediator of AP-1-driven gene expression and endothelial angiogenic function. PMID: 24103565
    8. TXNDC5 has increased expression in many tumors that is involved in the proliferation and migration of tumor cells, acting as a tumor-enhancing gene. PMID: 24100949
    9. results suggest that TXNDC5 polymorphisms could be related to the development of HCC in the Korean male population PMID: 24023338
    10. Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46. PMID: 23713588
    11. Hypoxia induced TXCNDC5 expression, which contributed to adiponectin expression, cytokine production and the cellular proliferation and migration of fibroblasts in rheumatoid arthritis. PMID: 23326410
    12. Authors show that ERp46 is able to bind to a large pool of peptides containing aromatic and basic residues via all three of its catalytic domains (a(0), a and a'), though the a(0) domain may contain the primary binding site. PMID: 23376096
    13. crystal structure of the third catalytic domain of protein disulfide isomerase ERp46 (also known as protein disulfide isomerase A5 and TXNDC5) was determined to 2.0 A resolution PMID: 22505402
    14. TXNDC5 has a genetic effect on the risk of rheumatoid arthritis and ankylosing spondylitis PMID: 21801346
    15. Overexpression of the TXNDC5 protein is associated with non-small cell lung carcinoma. PMID: 21617212
    16. results suggest that TXNDC5 gene polymorphisms are associated with the development of nonsegmental vitiligo in the Korean population. PMID: 19906073
    17. TXNDC5 can promote the growth and proliferation of gastric cells. Silencing of TXNDC5 can restrain the growth and proliferation of gastric cancer cells. PMID: 20157732
    18. these results establish ERp46 as the first AdipoR1-specific interacting protein and suggest a role for ERp46 in adiponectin receptor biology and adiponectin signalling. PMID: 20074551
    19. ERp46 has specificity towards peroxiredoxin-4, a thioredoxin peroxidase. PMID: 19887585
    20. upregulation of TXNDC5 are involved in the early development of colorectal cancer PMID: 17895523
    21. Member of the protein disulphide isomerase family and highly expressed in endothelial cells. Protects endothelial cells from apoptosis under hypoxia. PMID: 12963716

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  • 亞細胞定位：
    Endoplasmic reticulum lumen.
  • 蛋白家族：
    Protein disulfide isomerase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 21073

    OMIM: 616412

    KEGG: hsa:81567

    STRING: 9606.ENSP00000369081

    UniGene: Hs.150837