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  4. Human Transforming growth factor beta receptor type 3(TGFBR3) ELISA kit

Human Transforming growth factor beta receptor type 3(TGFBR3) ELISA kit

  • 中文名稱：
    人轉(zhuǎn)化生長因子β受體3(TGFBR3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023453HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人轉(zhuǎn)化生長因子β受體3(TGFBR3)酶聯(lián)免疫試劑盒（CSB-EL023453HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TGFBR3含量。TGFBR3是一個靶點。它屬于轉(zhuǎn)化生長因子β（TGF-β）超家族成員，在細(xì)胞生長、分化等多種生理過程中發(fā)揮重要作用。研究機制主要聚焦于其在信號通路中的功能，探究其與疾病發(fā)生發(fā)展的關(guān)聯(lián)以尋找潛在治療干預(yù)點。適用于體外培養(yǎng)模型、動物實驗樣本或疾病相關(guān)生物標(biāo)志物研究，可為探究TGFBR3在心血管疾病、腫瘤轉(zhuǎn)移或免疫調(diào)節(jié)中的分子機制提供可靠數(shù)據(jù)支持本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Beta glycan ELISA Kit; Betaglycan ELISA Kit; Betaglycan proteoglycan ELISA Kit; BGCAN ELISA Kit; TGBR3_HUMAN ELISA Kit; TGF beta receptor type 3 ELISA Kit; TGF beta receptor type III ELISA Kit; TGF-beta receptor type 3 ELISA Kit; TGF-beta receptor type III ELISA Kit; TGFB R3 ELISA Kit; TGFBR 3 ELISA Kit; TGFBR3 ELISA Kit; TGFR 3 ELISA Kit; TGFR-3 ELISA Kit; TGFR3 ELISA Kit; Transforming growth factor beta receptor III ELISA Kit; Transforming growth factor beta receptor III betaglycan 300kDa ELISA Kit; Transforming growth factor beta receptor type 3 ELISA Kit
  • 縮寫：
    TGFBR3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    Request Information
  • 靈敏度：
    Request Information
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

    　

    Intra-Assay Precision

    Inter-Assay Precision

    Sample

    1

    2

    3

    1

    2

    3

    n

    20

    20

    20

    20

    20

    20

    Mean(ng/ml)

    1.262

    1.234

    1.214

    1.253

    1.272

    1.214

    SD

    0.034

    0.032

    0.037

    0.048

    0.053

    0.050

    CV(%)

    4.057

    3.874

    4.529

    5.755

    6.295

    6.120

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of human TGFBR3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:5

    Average %

    105

    Range %

    100-110

    1:10

    Average %

    92

    Range %

    88-96

    1:20

    Average %

    87

    Range %

    82-91

    1:40

    Average %

    95

    Range %

    90-100

  • 回收率：

    The recovery of human TGFBR3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    89

    85-93

    EDTA plasma (n=4)

    94

    90-98

  • 標(biāo)準(zhǔn)曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    10

    2.417

    2.317

    2.367

    2.196

    5

    1.924

    1.796

    1.860

    1.689

    2.5

    1.252

    1.275

    1.264

    1.093

    1.25

    0.815

    0.842

    0.829

    0.658

    0.625

    0.579

    0.569

    0.574

    0.403

    0.312

    0.406

    0.423

    0.415

    0.244

    0.156

    0.281

    0.274

    0.278

    0.107

    0

    0.173

    0.168

    0.171

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
  • 基因功能參考文獻(xiàn)：
    1. describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells PMID: 29050936
    2. TGFBR3 and/or MGEA5 rearrangements are much more common in hybrid hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas. PMID: 26980036
    3. opposing functions for the different GAG modifications on TbetaRIII suggesting that Wnt interactions with the TbetaRIII heparan sulfate chains result in inhibition of Wnt signaling, likely via Wnt sequestration, whereas the chondroitin sulfate GAG chains on TbetaRIII promote Wnt3a signaling. PMID: 27784788
    4. Results suggest that high expression levels of alpha-inhibin and beta-glycan transcripts in secretory phase endometrium are associated with a lower chance of achieving pregnancy with in vitro fertilization. PMID: 27628954
    5. Results show decreased TbetaRIII expression with hepatocellullar carcinoma (HCC) progression leading to the activation of Smad2 and suggest that TbetaRIII acts as a suppressive factor in regulating the migration and invasion of HCC, by inhibiting Smad2 and Akt pathways. PMID: 26882862
    6. Study shows that TbetaRIII expression is significantly decreased in salivary glands adenoid cystic carcinoma (ACC) patients and defines TbetaRIII as a biomarker exerting antitumor action on ACC progression. PMID: 26531330
    7. No correlation of loss of heterozygosity at the TGFBR3 locus with clinicopathological parameters suggests that allelic imbalance may be an early genetic event during neoplastic transformation of human endometrium. PMID: 26548418
    8. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
    9. Data suggest a high potential of plasma sTBFbetarIII as a novel diagnostic and prognostic biomarker in breast cancer. PMID: 26190421
    10. rs1192415 of TGFBR3 is associated with primary open angle glaucoma. PMID: 25861811
    11. The presence of the index SNP rs1192415 (TGFBR3-CDC7) was associated with visual field progression in POAG (primary open-angle glaucoma) patients. PMID: 26383992
    12. Inhibiting ectodomain shedding of TbetaRIII increased TGF-beta responsiveness and abrogated TbetaRIII's ability to inhibit breast cancer cell migration and invasion. PMID: 24966170
    13. RS1805110 is not associated with Behcet's disease or idiopathic intermediate uveitis in Caucasian patients. PMID: 25677673
    14. data suggest complex or phenotype specific association of cryptorchidism with TGFBR3 and the gubernaculum as a potential target of TGFbeta signaling PMID: 25390077
    15. We have found that TbetaRIII is required for migration and invasion in vitro and xenograft growth in vivo. PMID: 24985072
    16. These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells. PMID: 25077702
    17. Proper localization of TGFBRIII is critical for maintenance of epithelial cell polarity and phenotype. PMID: 24870032
    18. TGFBR3 co-downregulated with GATA3 is associated with methylation of the GATA3 gene in bladder urothelial carcinoma. PMID: 24124001
    19. Report the presence of TGFBR3 and/or MGEA5 rearrangements in pleomorphic hyalinizing angiectatic tumors and the spectrum of related neoplasms. PMID: 24705316
    20. Therefore transient overexpression of TGFBR3 may be a novel strategy for nasopharyngeal carcinoma prevention and therapy PMID: 23387308
    21. Low TGFBR3 expression is associated with bladder urothelial carcinoma and enhanced in the invasive bladder cancer. PMID: 23835618
    22. Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression. PMID: 24658685
    23. TbetaRIII bound FGF2 and exogenous FGFR1, which promoted neuronal differentiation of neuroblastoma cells. TbetaRIII and FGF2 cooperated to induce expression of the transcription factor inhibitor of DNA binding 1 via Erk MAPK. PMID: 24216509
    24. These results reveal a novel function of the matricellular protein CCN6 and establish a mechanistic link between CCN6 and TbetaRIII in maintaining acinar organization in the breast. PMID: 23226100
    25. Clinically relevant role for TbetaRIII in regulating integrin alpha5 localization, reveal a novel crosstalk mechanism between the integrin and TGF-beta superfamily signaling pathways. PMID: 22562249
    26. Polymorphisms in the betaglycan gene, a co-receptor mediating functional antagonism of activin signalling, significantly predict antidepressant drug treatment outcome in a system-wide pharmacogenetics study in depression. PMID: 23092981
    27. a differential regulation of Smads and TGF-beta receptors PMID: 22927969
    28. Variations in TGFBR3 gene appear not to be associated with Marfan syndrome or related phenotype. PMID: 22300218
    29. Novel missense mutations in the TGFBR3 gene are associated with premature ovarian failure in Chinese women. PMID: 22036907
    30. rs1805110 CC genotype in TGFBR3 is probably associated with the protection from BD. The tested two TGFBR3 SNPs are not associated with VKH disease. PMID: 22440163
    31. TGFBR3 mutations may be responsible for the genetic aetiology of idiopathic premature ovarian failure in Chinese patients. PMID: 21756058
    32. Markers located in the region of TGFBR3 and BMP7 showed association with all testicular dysgenesis syndrome phenotypes in both the discovery and replication cohorts PMID: 22140272
    33. TGFBR3 polymorphisms and its haplotypes might be associated with hepatitis B virus clearance and age of hepatocellular carcinoma occurrence. PMID: 21829018
    34. Chromosomal translocation t(1;10) is consistent with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. PMID: 21717526
    35. These data support a model whereby TbetaRIII mediates TGF-beta superfamily ligand-induced colon cancer progression and support a context-dependent role for TbetaRIII in regulating cancer progression. PMID: 21847367
    36. type III transforming growth factor-beta protein expression is decreased in human multiple myeloma specimens. PMID: 21411633
    37. Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID: 21307088
    38. endometrial cancer is associated with disruption of accessory receptor betaglycan expression, what may alter TGFbeta2-induced signaling. PMID: 21261473
    39. TGFBR3 is associated with acute lung injury in mice PMID: 21297076
    40. Association of genetic variants in TGFBR3 and asthma in a Korean population. PMID: 20386084
    41. Reduced expression of TGFBR3 was observed in non-small cell lung cancer(NSCLC) cell lines, especially in 95D, suggesting that TGFBR3 might play an important role in development and progression of NSCLC. PMID: 20677641
    42. Use of sucrose-density ultracentrifugation to isolate membrane-raft fractions demonstrates recruitment of both TGFBbeta receptor (TGFbetaR)II and TGFbetaRI to non-raft membrane fractions by TGFbetaRIII. PMID: 20406198
    43. Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. PMID: 20208565
    44. report demonstrates the aberrantly increased expression of betaglycan mRNA in polycystic ovary syndrome ovaries; mechanism by which betaglycan contributes to the pathologic process of PCOS remains to be clarified PMID: 20178540
    45. A review on the role of TbetaRIII as a suppressor of cancer progression and/or as a metastasis suppressor. PMID: 20153821
    46. Partial plasmin digestion of soluble betaglycan produces two proteolysis-resistant fragments of 45 and 55 kilodaltons (kDa) corresponding, respectively, to betaglucan membrane-distal and -proximal regions. PMID: 19842711
    47. endoglin and betaglycan have a critical role in the regulation of TGFbeta signaling in chondrocytes PMID: 12568406
    48. Results quantify the relative expression of inhibin alpha, inhibin/activin beta(A), beta(B), beta(C), follistatin, activin receptors and beta-glycan genes in placental tissue of term pre-eclamptic patients. PMID: 12651901
    49. analysis of expression and cellular compartmentalization of the activin receptors ActRIIA, ActRIIB and ActRIB, the inhibin co-receptor (betaglycan), and activin signaling proteins Smads 2, 3 and 4, and growth regulatory role during lactation PMID: 12782414
    50. findings indicate a physiologically significant, unanticipated role for beta arrestin 2 in regulating TGF-beta signaling through internalization and subsequent decreased signaling of TGF-beta receptors PMID: 12958365

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  • 亞細(xì)胞定位：
    Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Note=Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11774

    OMIM: 600742

    KEGG: hsa:7049

    STRING: 9606.ENSP00000212355

    UniGene: Hs.482390