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  4. Human Troponin I, slow skeletal muscle(TNNI1) ELISA kit

Human Troponin I, slow skeletal muscle(TNNI1) ELISA kit

  • 中文名稱：
    人肌鈣蛋白I，骨骼肌慢肌(TNNI1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL024011HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人肌鈣蛋白I，骨骼肌慢肌(TNNI1)酶聯(lián)免疫試劑盒（CSB-EL024011HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿樣本中的TNNI1含量。TNNI1 即心肌肌鈣蛋白 I1，是心肌肌鈣蛋白復(fù)合物的調(diào)節(jié)亞基。研究聚焦于其在心肌收縮舒張調(diào)控中的作用機(jī)制。異常表達(dá)或修飾可能影響心肌功能，它可作為心肌疾病如心肌病等潛在診斷和治療靶點(diǎn)，為相關(guān)疾病干預(yù)開(kāi)辟新思路。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，適用于科研領(lǐng)域中對(duì)骨骼肌功能機(jī)制、運(yùn)動(dòng)相關(guān)代謝研究、肌肉退行性疾病模型構(gòu)建及藥物干預(yù)效果評(píng)估等場(chǎng)景，為探索TNNI1在肌肉生理及病理過(guò)程中的作用提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    2700018B22Rik ELISA Kit; AI747285 ELISA Kit; DKFZp451O223 ELISA Kit; si:dz182n13.3 ELISA Kit; slow skeletal muscle ELISA Kit; slow-twitch isoform ELISA Kit; SSTNI ELISA Kit; TNN1 ELISA Kit; Tnni1 ELISA Kit; TNNI1_HUMAN ELISA Kit; Troponin I ELISA Kit; Troponin I slow skeletal muscle ELISA Kit; Troponin I slow twitch isoform ELISA Kit; troponin I type 1 (skeletal; slow) ELISA Kit; Troponin I; slow isoform ELISA Kit
  • 縮寫：
    TNNI1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TNNI1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %91
    Range %86-95
    1:2Average %102
    Range %97-107
    1:4Average %91
    Range %85-97
    1:8Average %97
    Range %91-103
  • 回收率：
    The recovery of human TNNI1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-98
    EDTA plasma (n=4)9490-98
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    202.743 2.768 2.756 2.615
    101.919 1.909 1.914 1.773
    51.056 1.087 1.072 0.931
    2.50.584 0.580 0.582 0.441
    1.250.357 0.387 0.372 0.231
    0.6250.283 0.299 0.291 0.150
    0.3120.194 0.198 0.196 0.055
    00.142 0.140 0.141
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

相關(guān)問(wèn)答

■ 常見(jiàn)問(wèn)題解答
Q:


HOW MANY DETERMINATIONS CAN BE PERFORMED WITH THE 24T ELISA KIT FOR TROPONIN I

A:
Thanks for your inquiry!
CSB-EL024011HU
The standard is S0-S7. You can test 16 samples if you run single well.

靶點(diǎn)詳情

  • 功能：
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能參考文獻(xiàn)：
    1. Ultrasensitive troponin I was detectable in almost all individuals of a study sample reflecting middle-aged to elderly European general population. Ultrasensitive troponin concentrations exhibit an independent, graded, positive relation with incident CHD [coronary heart disease]. PMID: 28585121
    2. Measuring mean platelet volume in conjunction with troponin I levels improves the diagnostic value of troponin I in acute coronary syndrome. PMID: 27524214
    3. CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage. PMID: 26334851
    4. TNNI3K is a cardiac-specific gene, encoding a cardiac troponin I-interacting MAP kinase. In mice, Tnni3k is shown to play an important role in the regulation of cardiac differentiation and cardiac contractility PMID: 25791106
    5. sTnI as a sensitive marker of skeletal muscle injury. PMID: 22323298
    6. Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality. PMID: 22374183
    7. Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery. PMID: 19811558
    8. Evaluated the prevalence of TNN13 gene mutations in sudden death caused by cardiomyopathy (CM); in dilated CM cases, a new missense mutation Pro16Thr was detected. A single nucleotide polymorphism at -8 position of intron 3 was identified. PMID: 20817590
    9. troponin I phosphorylation has a role in protein kinase C-mediated enhanced contractile performance of myocytes PMID: 12815045
    10. MEF2 activation of the troponin I slow enhancer is repressed by hMusTRD1alpha1 PMID: 12857748
    11. Low expression of ssTnI was found in 60% of patients in sinus rhythm or paroxysmal AF and in 8% of patients with chronic AF. Relative ssTnI mRNA expression was significantly lower in patients with AF than in those in sinus rhythm. PMID: 15289369
    12. A biological marker of myocardial injury, but may also be increased after a grand mal seizure. PMID: 15367881
    13. These results suggest that this R21C mutation in TnI affects the Ca(2+)-sensitizing effect of Tn, the ability of TnI to be readily phosphorylated by PKA and the stability of TnI to calpain. PMID: 16005017
    14. Relationship between myocardial injury, assessed by cardiac troponin I (cTnI) levels, and outcome in selected critically ill patients without acute coronary syndromes or cardiac dysfunction PMID: 16236952
    15. This marker in paatients with heart failure and anemia identifies patients at particularly high risk mortality. PMID: 16338262
    16. Increased serum levels of troponin I is associated with calcinosis and coronary Artery Stenosis PMID: 16358990
    17. The plasma levels of CRP and troponin I were also significantly higher in this group of nine patients, and correlated with urinary protein excretion. PMID: 16916777
    18. A revised method of troponin exchange in pemeabilized cardiac trabeculae using vanadate: functional consequences of a HCM-causing mutation in troponin I. PMID: 17051347
    19. a localized N-terminal region of TnI comprised of amino acids 33-80, which interacts with C-terminal regions of cTnC and cTnT, is of particular significance in transducing signaling of thin filament activation by strong cross-bridges PMID: 17099250

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  • 蛋白家族：
    Troponin I family
  • 組織特異性：
    Highest levels observed in human skeletal muscle (e.g. gastrocnemious muscle), differentiated cultures of primary human muscle cells and rhabdomyosarcoma cells cultured in low serum medium. Expressed in C2 muscle cell myoblasts and myotubes.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 11945

    OMIM: 191042

    KEGG: hsa:7135

    STRING: 9606.ENSP00000337022

    UniGene: Hs.320890