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  4. Human Troponin T, fast skeletal muscle(TNNT3) ELISA kit

Human Troponin T, fast skeletal muscle(TNNT3) ELISA kit

  • 中文名稱：
    人肌鈣蛋白T，骨骼肌快肌(TNNT3)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL024017HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人肌鈣蛋白T，骨骼肌快肌(TNNT3)酶聯(lián)免疫試劑盒（CSB-EL024017HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的TNNT3含量。TNNT3是重要靶點(diǎn)，它是心肌肌鈣蛋白T的一種亞型。在研究機(jī)制上，它與心肌收縮功能緊密相關(guān)，其結(jié)構(gòu)和功能變化會(huì)影響心肌收縮舒張。對(duì)它的深入研究有助于揭示心肌病等心臟疾病發(fā)病機(jī)制，為相關(guān)疾病診斷和治療提供新方向。試劑盒檢測(cè)范圍為7.81 pg/mL-500 pg/mL，該產(chǎn)品可應(yīng)用于運(yùn)動(dòng)科學(xué)領(lǐng)域研究運(yùn)動(dòng)后骨骼肌損傷的生物標(biāo)志物動(dòng)態(tài)變化，或用于肌肉疾病模型中TNNT3表達(dá)調(diào)控機(jī)制的探索，亦支持基因編輯細(xì)胞或動(dòng)物模型的功能驗(yàn)證實(shí)驗(yàn)，為骨骼肌生理及病理機(jī)制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    AMCD2B ELISA Kit; Beta TnTF ELISA Kit; Beta-TnTF ELISA Kit; DA2B ELISA Kit; DKFZp779M2348 ELISA Kit; fast skeletal muscle ELISA Kit; Fast skeletal muscle troponin T ELISA Kit; FSSV ELISA Kit; fTnT ELISA Kit; TNNT 3 ELISA Kit; Tnnt3 ELISA Kit; TNNT3_HUMAN ELISA Kit; TnTf ELISA Kit; Troponin T ELISA Kit; Troponin T fast skeletal muscle ELISA Kit; Troponin T type 3 (skeletal fast) ELISA Kit; Troponin T type 3 ELISA Kit; Troponin T3 skeletal fast ELISA Kit
  • 縮寫：
    TNNT3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    7.81 pg/mL-500 pg/mL
  • 靈敏度：
    1.95 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TNNT3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 98
    Range % 89-101
    1:2 Average % 107
    Range % 99-111
    1:4 Average % 92
    Range % 84-95
    1:8 Average % 99
    Range % 90-103
  • 回收率：
    The recovery of human TNNT3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 104 95-108
    EDTA plasma (n=4) 98 92-101
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    500 2.033 1.963 1.998 1.872
    250 1.731 1.778 1.755 1.629
    125 1.255 1.289 1.272 1.146
    62.5 0.596 0.634 0.615 0.489
    31.25 0.297 0.308 0.303 0.177
    15.62 0.189 0.197 0.193 0.067
    7.81 0.153 0.150 0.152 0.026
    0 0.128 0.124 0.126 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能參考文獻(xiàn)：
    1. The presence of the p.(Arg63His) missense mutation at position 63 of TNNT3 was confirmed through direct cycle sequencing of genomic DNA in six affected South African family members for whom DNA had been archived. PMID: 26915936
    2. Data show that a missense mutation at nucleotide position 187 in exon 9 of the TNNT3 gene was identified in all affected individuals in the family. PMID: 21402185
    3. TNNT3 and LDB3 showed abnormal splicing and appeared more pronounced in myotonic dystrophies type 2 relative to myotonic dystrophies type 1. PMID: 20066428
    4. These results indicate that the f peptide confers an inhibitory effect on the biological function of fast skeletal troponin T and this can be correlated with changes in the Ca2+ regulation associated with development in fast skeletal muscle. PMID: 16081096
    5. Skeletal muscle contractile gene (TNNT3, MYH3, TPM2) mutations not found in vertical talus or clubfoot. PMID: 19142688
    6. Myotonic dystrophy type 2 muscles exhibited a higher degree of alternative splicing dysregulation for fast TnT transcripts when compared to myotonic dystrophy type 1 muscles. PMID: 19326042

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  • 相關(guān)疾病：
    Arthrogryposis, distal, 2B (DA2B)
  • 蛋白家族：
    Troponin T family
  • 組織特異性：
    In fetal and adult fast skeletal muscles, with a higher level expression in fetal than in adult muscle.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 11950

    OMIM: 600692

    KEGG: hsa:7140

    STRING: 9606.ENSP00000278317

    UniGene: Hs.73454