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  4. Human Tumor necrosis factor ligand superfamily member 18(TNFSF18) ELISA kit

Human Tumor necrosis factor ligand superfamily member 18(TNFSF18) ELISA kit

  • 中文名稱：
    人腫瘤壞死因子配體超家族成員18(TNFSF18)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL023993HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人腫瘤壞死因子配體超家族成員18(TNFSF18)酶聯(lián)免疫試劑盒（CSB-EL023993HU）檢測樣本中的TNFSF18含量。TNFSF18 作為一個靶點，在免疫調(diào)節(jié)等生理過程中發(fā)揮重要作用。其背景與腫瘤壞死因子超家族相關(guān)。研究機制主要圍繞它與受體相互作用，調(diào)控免疫細胞的活性、增殖等，有望為免疫相關(guān)疾病及腫瘤治療提供新的策略?？捎糜谔剿鱐NFSF18在免疫調(diào)控機制中的作用、評估實驗性藥物對靶點表達的影響，或作為疾病模型中生物標志物的定量研究工具，為免疫學(xué)、腫瘤學(xué)等基礎(chǔ)研究提供可靠數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Activation inducible TNF related ligand ELISA Kit; Activation-inducible TNF-related ligand ELISA Kit; AITR ligand ELISA Kit; AITRL ELISA Kit; GITR ligand ELISA Kit; GITRL ELISA Kit; Glucocorticoid induced TNF related ligand ELISA Kit; Glucocorticoid induced TNFR related protein ligand ELISA Kit; Glucocorticoid-induced TNF-related ligand ELISA Kit; hGITRL ELISA Kit; MGC138237 ELISA Kit; TL6 ELISA Kit; TNF18_HUMAN ELISA Kit; TNFSF18 ELISA Kit; TNLG2A ELISA Kit; Tumor necrosis factor (ligand) superfamily member 18 ELISA Kit; Tumor necrosis factor ligand 2A ELISA Kit; Tumor necrosis factor ligand superfamily member 18 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 檢測范圍：
    Request Information
  • 靈敏度：
    Request Information
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
  • 基因功能參考文獻：
    1. GITRL levels are significantly elevated in rheumatoid arthritis serum and synovial fluid and are positively correlated with autoantibody production in rheumatoid arthritis, suggesting a role of GITRL in the development of rheumatoid arthritis. PMID: 27098050
    2. GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis. PMID: 26657118
    3. An increase in GITRL may impair the balance of Th17/Treg, and contribute to the pathopoiesis of Hashimoto's thyroiditis. PMID: 25429429
    4. Serum GITRL levels were higher in SLE patients. PMID: 23251213
    5. Glucocorticoid-induced TNF-related ligand (GITRL) confers pseudoexpression to tumor cells by platelets, which results in GITRL expression by megakaryocytes and their platelet progeny. PMID: 22649191
    6. observation suggests a link between cytokine-regulated keratinocyte GITRL expression and its role in inflammatory responses in AD PMID: 22417213
    7. GITRL upregulation induced by IFN-beta on dendritic cells downregulates CTLA-4 on regulatory T (Treg) cells, facilitating proliferation of anergic Treg cells in multiple sclerosis treatment of multiple sclerosis patients. PMID: 22112394
    8. GITRL expression on Kupffer cells may mediate acute rejection in liver transplantation PMID: 21693309
    9. The incorporation of an isoleucine zipper motif could markedly improve the costimulation of hsGITRL. PMID: 20228835
    10. Upregulation by proinflammatory cytokines suggests GITRL may play important role in ocular immunity. High level of constitutive GITRL expression on photoreceptor inner segments suggests photoreceptors participate in regulation of ocular inflammation. PMID: 15326137
    11. Regulates ossteoclasst genersation and substantiate the major role played by the endothelium in bone physiology. PMID: 16179414
    12. Using a GITRL-transfected cell line, we demonstrate that GITRL promotes NK cell cytotoxicity and IFN-gamma production. PMID: 16397134
    13. GITRL could be a potential candidate for regulation of the ocular immune privilege and the balance between immune privilege and inflammation PMID: 16874737
    14. Constitutive expression of GITRL by tumor cells diminishes natural killer cell antitumor immunity. PMID: 17360848
    15. although huGITRL is not capable of alleviating Treg suppression of responder T cells, huGITRL overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses PMID: 17449724
    16. These observations raise the possibility that the GITRL-mediated inflammatory activation of macrophages is involved in the pathogenesis of inflammatory diseases. PMID: 17602748
    17. Levels of AITRL were significantly increased in serum of breast cancer patients PMID: 17914571
    18. hGITRL ectodomain displays considerable self-association/dissociation in solution with a dynamic equilibrium between trimeric and monomeric forms over the range of protein concentrations studied. PMID: 18040044
    19. identify multiple oligomeric species of hGITRL that possess distinct kinetics of ERK activation. PMID: 18378892
    20. The strong correlation of tumor incidence and elevated soluble GITRL levels indicates that soluble GITRL is released from cancers in vivo, leading to impaired NK cell immunosurveillance of tumors PMID: 18689545

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  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Tumor necrosis factor family
  • 組織特異性：
    Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11932

    OMIM: 603898

    KEGG: hsa:8995

    STRING: 9606.ENSP00000385470

    UniGene: Hs.248197