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  4. Human Twisted gastrulation protein homolog 1(TWSG1) ELISA kit

Human Twisted gastrulation protein homolog 1(TWSG1) ELISA kit

  • 中文名稱：
    人扭曲原腸胚蛋白同源物1(TWSG1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL025361HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人扭曲原腸胚蛋白同源物1(TWSG1)酶聯(lián)免疫試劑盒（CSB-EL025361HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的TWSG1含量。TWSG1是一種與BMP信號通路相關(guān)的蛋白，在胚胎發(fā)育和組織穩(wěn)態(tài)中起重要作用。它通過形成三元復(fù)合物與CHRD和BMP結(jié)合，既充當(dāng)拮抗劑又充當(dāng)激動劑，影響B(tài)MP信號傳導(dǎo)。TWSG1在軟骨發(fā)育、細胞分化等過程中發(fā)揮關(guān)鍵作用，其功能研究有助于理解相關(guān)疾病的發(fā)生機制。試劑盒檢測范圍為125 pg/mL-8000 pg/mL，該產(chǎn)品適用于基礎(chǔ)科研領(lǐng)域，如探索TWSG1在胚胎發(fā)育調(diào)控、骨骼疾病機制、腫瘤微環(huán)境調(diào)控或代謝相關(guān)信號通路中的功能，也可用于評估疾病模型中TWSG1的表達水平變化，為相關(guān)分子機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    PSEC0250 ELISA Kit; twisted gastrulation homolog 1 (Drosophila) ELISA Kit; TSG ELISA Kit; TSG1 ELISA Kit; Twisted gastrulation BMP signaling modulator 1 ELISA Kit; Twisted gastrulation homolog 1 ELISA Kit; Twisted gastrulation protein ELISA Kit; Twisted gastrulation protein homolog 1 ELISA Kit; TWSG1 ELISA Kit; TWSG1_HUMAN ELISA Kit
  • 縮寫：
    TWSG1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    125 pg/mL-8000 pg/mL
  • 靈敏度：
    31.25 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TWSG1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %90
    Range %86-96
    1:2Average %99
    Range %92-106
    1:4Average %89
    Range %83-94
    1:8Average %92
    Range %87-98
  • 回收率：
    The recovery of human TWSG1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9490-99
    EDTA plasma (n=4)8480-88
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    80002.557 2.765 2.661 2.542
    40001.816 1.902 1.859 1.740
    20001.103 1.189 1.146 1.027
    10000.707 0.714 0.711 0.592
    5000.405 0.374 0.390 0.271
    2500.312 0.309 0.311 0.192
    1250.205 0.201 0.203 0.084
    00.123 0.115 0.119 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
  • 基因功能參考文獻：
    1. Findings indicate that twisted gastrulation homolog 1 (TWSG1) maybe serves as a tumor suppressor gene in gastric cancer and potential biomarker or therapeutic target for the diagnosis and treatment of gastric cancer. PMID: 29756996
    2. Tsg functions as a BMP-agonist by inducing conformational change in chordin making it more susceptible to tolloid cleavage and as a BMP-antagonist either independently or via a chordin-mediated mechanism. PMID: 26829466
    3. Data suggest CHRD (chordin) cleavage by tolloid-like metalloproteinases is insufficient to regulate BMP(bone morphogenetic protein)/BMPR signaling; CHRD fragments and TSG (twisted gastrulation protein) contribute to inhibition of BMP/BMPR signaling. PMID: 26517884
    4. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis. PMID: 23641068
    5. mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies PMID: 21227728
    6. Tsg functions as an agonist synergizing with TGF-beta to inhibit T-cell activation. PMID: 17164348
    7. interferes with BMP-mediated hepcidin expression and may act with GDF15 to dysregulate iron homeostasis in thalassemia syndromes. PMID: 19414861

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Twisted gastrulation protein family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12429

    OMIM: 605049

    KEGG: hsa:57045

    STRING: 9606.ENSP00000262120

    UniGene: Hs.514685