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  4. Human U3 small nucleolar ribonucleoprotein protein IMP3(IMP3) ELISA kit

Human U3 small nucleolar ribonucleoprotein protein IMP3(IMP3) ELISA kit

  • 中文名稱：
    人U3小核糖核蛋白IMP3(IMP3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL011692HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人U3小核糖核蛋白IMP3(IMP3)酶聯(lián)免疫試劑盒（CSB-EL011692HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的IMP3含量。IMP3 是近年來受關(guān)注的靶點。它與腫瘤發(fā)生發(fā)展密切相關(guān)，在多種腫瘤組織中高表達(dá)。研究顯示其可調(diào)控細(xì)胞增殖、凋亡與轉(zhuǎn)移等過程，有望成為腫瘤診斷標(biāo)志物和治療靶點，為癌癥精準(zhǔn)治療提供新思路。試劑盒檢測范圍為39 pg/mL-2500 pg/mL，本試劑盒通過高特異性抗體對實現(xiàn)目標(biāo)蛋白的精準(zhǔn)捕獲與信號放大，可滿足科研場景下對IMP3蛋白表達(dá)水平的定量分析需求，例如腫瘤生物學(xué)研究中的分子機(jī)制探索、細(xì)胞功能實驗中的蛋白動態(tài)監(jiān)測或疾病模型構(gòu)建中的生物標(biāo)志物驗證等，為體外樣本中IMP3的定量檢測提供標(biāo)準(zhǔn)化工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    BRMS2 ELISA Kit; C15orf12 ELISA Kit; Chromosome 15 open reading frame 12 ELISA Kit; DKFZp586L0118 ELISA Kit; FLJ10968 ELISA Kit; imp3 ELISA Kit; IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) ELISA Kit; IMP3_HUMAN ELISA Kit; Mitochondrial ribosomal protein S4 ELISA Kit; MRPS4 ELISA Kit; OTTHUMP00000183524 ELISA Kit; U3 small nucleolar ribonucleoprotein protein imp3 ELISA Kit; U3 snoRNP protein 3 homolog ELISA Kit; U3 snoRNP protein imp3 ELISA Kit
  • 縮寫：
    IMP3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    39 pg/mL-2500 pg/mL
  • 靈敏度：
    9.75 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human IMP3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 95
    Range % 89-99
    1:2 Average % 97
    Range % 91-103
    1:4 Average % 92
    Range % 87-98
    1:8 Average % 89
    Range % 85-93
  • 回收率：
    The recovery of human IMP3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 102 98-105
    EDTA plasma (n=4) 86 80-91
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2500 2.445 2.555 2.500 2.344
    1250 1.791 1.861 1.826 1.670
    625 1.232 1.287 1.260 1.104
    312 0.866 0.877 0.872 0.716
    156 0.580 0.593 0.587 0.431
    78 0.437 0.424 0.431 0.275
    39 0.283 0.289 0.286 0.130
    0 0.155 0.156 0.156 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
  • 基因功能參考文獻(xiàn)：
    1. our study found that IMP3 expression was higher in the ovarian clear cell carcinoma than the high grade serous and endometrioid subtypes PMID: 29866423
    2. IMP3 expression in uterine leiomyosarcoma could be a marker of a poor prognosis. PMID: 29077232
    3. IMP3 positive pT1 EAC revealed higher levels of lymph node metastases. PMID: 29974234
    4. IMP3 is a strong prognostic factor in non-neuroendocrine brain metastases and in particular in patients with adenocarcinoma metastases.IMP3 expression is associated with poor prognosis in patients with non-small cell lung cancer brain metastases. PMID: 29209838
    5. Study found IMP3 frequently overexpressed in many human neoplasms and show significant associations with adverse tumor features in esophageal adenocarcinomas and cancers of the urinary bladder, lung, stomach, and pancreas. PMID: 29115542
    6. In this study, IMP3 at the nodal site resulted to be associated with low progression-free survival in small-intestine neuroendocrine neoplasms, independently of the Ki-67 index. PMID: 28210937
    7. IMP3 may contribute to the aggressive behavior of metaplastic breast carcinoma , and that this expression could potentially be a prognostic marker PMID: 29146055
    8. These findings suggest that IMP3 expression has prognostic value as a biomarker for chemosensitivity and overall survival in triple negative breast cancer PMID: 28756977
    9. This study establishes p65 as a novel target of IMP3 in increasing glioma cell migration and underscores the significance of IMP3-p65 feedback loop for therapeutic targeting in GBM. PMID: 28465487
    10. IMP3 has a similar specificity, but a better sensitivity, intensity, and extent of reactivity in comparison with AMACR, and may be used as an alternative to AMACR, in support of the diagnosis of BE-dysplasia and EAC PMID: 26766126

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  • 亞細(xì)胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    Universal ribosomal protein uS4 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14497

    OMIM: 612980

    KEGG: hsa:55272

    STRING: 9606.ENSP00000326981

    UniGene: Hs.513043