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  4. Human Urocortin-2(UCN2) ELISA kit

Human Urocortin-2(UCN2) ELISA kit

  • 中文名稱：
    人尿皮素-2(UCN2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL025552HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人尿皮素-2(UCN2)酶聯(lián)免疫試劑盒（CSB-EL025552HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、組織培養(yǎng)上清液樣本中的UCN2含量。UCN2 是一個靶點。UCN2 即尿皮質(zhì)素 2，屬促腎上腺皮質(zhì)激素釋放因子家族，參與調(diào)節(jié)應(yīng)激反應(yīng)、心血管功能及能量代謝。研究機制上，其通過與特定受體結(jié)合激活下游信號通路，為相關(guān)疾病如心血管病、代謝病的治療帶來新方向。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL，該產(chǎn)品適用于體外研究場景，如探究UCN2在代謝調(diào)控相關(guān)細胞模型中的分泌動態(tài)、動物實驗中的組織分布分析，或臨床前研究中的生物標志物探索，為心血管疾病、肥胖癥及應(yīng)激相關(guān)分子機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    SRP ELISA Kit; Stresscopin related peptide ELISA Kit; Stresscopin-related peptide ELISA Kit; Ucn II ELISA Kit; Ucn2 ELISA Kit; UCN2_HUMAN ELISA Kit; UCNI ELISA Kit; UCNII ELISA Kit; UR ELISA Kit; Urocortin II ELISA Kit; Urocortin related peptide ELISA Kit; Urocortin-2 ELISA Kit; Urocortin-related peptide ELISA Kit; URP ELISA Kit
  • 縮寫：
    UCN2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell culture supernates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human UCN2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %84
    Range %80-88
    1:2Average %90
    Range %85-95
    1:4Average %97
    Range %92-110
    1:8Average %93
    Range %86-98
  • 回收率：
    The recovery of human UCN2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9589-99
    EDTA plasma (n=4)104100-110
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    4002.258 2.302 2.280 2.142
    2001.735 1.696 1.716 1.578
    1001.126 1.101 1.114 0.976
    500.678 0.637 0.658 0.520
    250.412 0.434 0.423 0.285
    12.50.311 0.309 0.310 0.172
    6.250.243 0.254 0.249 0.111
    00.137 0.139 0.138
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
  • 基因功能參考文獻：
    1. laryngeal cancer cells were enriched in the recurrent chimera COL7A1-UCN2, which potentially affected cancer stem cell transition PMID: 29499655
    2. examination of the local and systemic cardiovascular effects of urocortin 2 and urocortin 3 in healthy subjects and patients with heart failure PMID: 27275843
    3. Data show that corticotropin releasing hormone receptor 2 (Crhr2) protein is abundantly expressed in the heart, and plasma Ucn2 levels were higher in patients with heart failure compared to healthy controls, indicating that endogenous Crhr2 is associated with heart failure. PMID: 28550160
    4. up-regulated in placenta, fetal membranes, and myometrium in labor PMID: 25426872
    5. Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes. PMID: 24835211
    6. Stresscopin-related peptide induces a weaker enhancement of cardiovascular function through corticotropin-releasing factor receptorn 2 than that induced by stresscopin. PMID: 23850799
    7. Solubilized SUMO-eXact-preproUCN2 was used successfully to generate two high affinity mouse monoclonal antibodies specific to the pro-region of urocortin 2. PMID: 24291344
    8. UCN2 is significantly associated with AAA and inhibits VSMC proliferation by inducing a G1 cell cycle arrest suggesting a plausible regulatory role in AAA pathogenesis PMID: 24107226
    9. UCNII caused cell death via different membrane-disrupting mechanisms that involve aggregation & membrane depolarization in bacteria and pore formation in Leishmania even inside macrophages. Innate immune cells produce UCNII in response to infections. PMID: 24249730
    10. Description of ucn2 posttranslational processing and peptide sequence. Hypoxia and glycosylation, paradigms that might influence secretion or processing of gene products, did not significantly impact hUcn 2 prohormone cleavage. PMID: 23493376
    11. study showed that Ucn2 and Ucn3 differentially regulate the LPS-induced TNF-alpha and IL-10 expression and secretion in trophoblast explants acting through CRH-R2. Ucn2 is proinflammatory. PMID: 22000474
    12. These data suggest a possible involvement of urocortin 2 and Ucn 3 in the mechanisms of endometriosis. PMID: 21454316
    13. Confirm the anti-inflammatory function of VIP, through the modulation of the expression of CRF system that impacts in a reduction of mediators with inflammatory/destructive functions. PMID: 21360527
    14. Unlike urocortin-1 levels, higher levels of urocortin 2 are not associated with worse left ventricular diastolic performance in patients with chronic systolic heart failure. PMID: 20670842
    15. Urocortin 2 may play a role in the regulation of estradiol production throughout pregnancy, thereby contributing to the placental regulation of key reproductive events in pregnancy maintenance and parturition. PMID: 19417223
    16. Placental Ucn2 and Ucn3 expression is sensitive to O(2) tensions and mediated by HIF-1alpha. In preeclampsia, the increased expression of both peptides may reflect a response to the oxidative stress. PMID: 20616367
    17. SCP and UCN are potent activators of the p42/44 MAPK pathway, with SRP able to induce phosphorylation of p42/44 MAPK as well, albeit not as pronounced PMID: 14519439
    18. data suggest a distinctive role for corticotropin-releasing hormone receptor 2 specific agonists like urocortin II in the control of myometrial contractility during human pregnancy PMID: 14592950
    19. data indicate that intracisternal Ucn 2 induced a central CRF(2)-mediated inhibition of gastric emptying involving sympathetic alpha(1)-adrenergic mechanisms independent from the vagus contrasting with the vagal-dependent inhibitory actions of CRF & Ucn 1 PMID: 16223946
    20. the 38 amino acid urocortin 2 peptide is the minimal pharmacophore PMID: 16476507
    21. UCN2 and UCN3 are expressed in human placenta, decidua, and fetal membranes and may be proposed as regulators of placental vascular endothelial tone. PMID: 16626608
    22. Both peptides were immunolocalized in epithelial, stromal, and endothelial cells. PMID: 17074339

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Sauvagine/corticotropin-releasing factor/urotensin I family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18414

    OMIM: 605902

    KEGG: hsa:90226

    STRING: 9606.ENSP00000273610

    UniGene: Hs.631914