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Human Urocortin-3(UCN3) ELISA kit

  • 中文名稱：
    人尿皮素-3(UCN3)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL025553HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人尿皮素-3(UCN3)酶聯(lián)免疫試劑盒（CSB-EL025553HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的UCN3含量。UCN3 是重要靶點，它屬于促皮質(zhì)素釋放因子家族成員。其在人體能量代謝、應(yīng)激反應(yīng)等生理過程中發(fā)揮作用。研究機制主要聚焦于它與受體的結(jié)合，以及相關(guān)信號通路的激活，借此探索在肥胖、糖尿病等疾病治療中的潛在價值。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL，可穩(wěn)定應(yīng)用于基礎(chǔ)科研領(lǐng)域，如探究UCN3在代謝性疾病動物模型中的表達(dá)變化、評估藥物干預(yù)對UCN3信號通路的影響，或通過臨床樣本分析其與病理狀態(tài)的相關(guān)性，支持實驗室常規(guī)研究與高通量篩選需求。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    UCN3 ELISA kit; SPCUrocortin-3 ELISA kit; Stresscopin ELISA kit; Urocortin III ELISA kit; Ucn III ELISA kit
  • 縮寫：
    UCN3
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human UCN3 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %86
    Range %83-89
    1:2Average %101
    Range %98-104
    1:4Average %105
    Range %101-109
    1:8Average %90
    Range %85-96
  • 回收率：
    The recovery of human UCN3 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8481-89
    EDTA plasma (n=4)9996-102
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    4002.604 2.638 2.621 2.416
    2002.284 2.114 2.199 1.994
    1001.555 1.598 1.577 1.372
    500.977 0.935 0.956 0.751
    250.551 0.587 0.569 0.364
    12.50.405 0.432 0.419 0.214
    6.250.304 0.318 0.311 0.106
    00.204 0.206 0.205
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.
  • 基因功能參考文獻：
    1. Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3 PMID: 27262310
    2. In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients. PMID: 27754786
    3. circulating levels elevated and positively correlated with C-reactive protein in polycystic ovary syndrome PMID: 26488073
    4. results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway PMID: 26350463
    5. The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin release to ensure the timely reduction of insulin secretion upon normalization of plasma glucose. PMID: 26076035
    6. The molecular modifications of urocortin 3[36-38] led to an improved understanding of the relationship between molecular structure and biological activity of this peptide, could be further tested for possible clinical treatment of depression PMID: 25304878
    7. Data suggest that UCN3 expression can serve as a late stage maturation/differentiation marker in beta-cells during pancreogenesis. [REVIEW] PMID: 25148370
    8. SCP inhibits a subpopulation of PVN neurons, especially OTergic magnocellular neurons, by enhancing the activity of GIRK channels via CRF-R2 PMID: 23349753
    9. study showed that Ucn2 and Ucn3 differentially regulate the LPS-induced TNF-alpha and IL-10 expression and secretion in trophoblast explants acting through CRH-R2. Ucn3 has an anti-inflammatory effect. PMID: 22000474
    10. CRH-R1:CRH-R2 ratio varied according to fat-depot type; whereas CRH-R1 expression was higher in sc fat than in visceral fat, the opposite was true for CRH-R2. PMID: 14764822
    11. Expression of Ucn III/SCP in the human heart and kidney as well as brain and pituitary tissues and its presence in plasma and urine. Ucn III/SCP may therefore regulate the cardiac and renal function as a local factor and a circulating hormone. PMID: 15070962
    12. Ucn 3 plays some physiological or pathological roles in the modulation of gastrointestinal functions during stressful conditions. PMID: 15949638
    13. Ucn3 is produced in the normal adrenal gland and in adrenal tumors (both adrenocortical tumors and pheochromocytomas) and acts as an autocrine or paracrine regulator in both the normal and cancerous adrenal gland tissue. PMID: 16095756
    14. the SCP/CRHR2 system is present in human ovaries and treatment with SCP/Ucn3 inhibits progesterone production by cultured granulosa-lutein cells through interaction with CRHR2 PMID: 19351656

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Sauvagine/corticotropin-releasing factor/urotensin I family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17781

    OMIM: 605901

    KEGG: hsa:114131

    STRING: 9606.ENSP00000369798

    UniGene: Hs.511775