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  4. Human Vascular cell adhesion molecule 1,VCAM-1 ELISA kit

Human Vascular cell adhesion molecule 1,VCAM-1 ELISA kit

  • 中文名稱：
    人血管內(nèi)皮細(xì)胞粘附分子1(VCAM-1/CD106)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E04753h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人血管內(nèi)皮細(xì)胞粘附分子1(VCAM-1/CD106)酶聯(lián)免疫試劑盒（CSB-E04753h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的VCAM1含量。VCAM1，即血管細(xì)胞粘附分子1，是一種免疫球蛋白超家族成員，主要表達(dá)在活化的內(nèi)皮細(xì)胞表面。它通過結(jié)合白細(xì)胞表面的特定分子，促進(jìn)白細(xì)胞轉(zhuǎn)移到組織中，參與免疫反應(yīng)和炎癥過程。研究顯示，VCAM1在衰老相關(guān)疾病中發(fā)揮重要作用，如阿爾茨海默病，其表達(dá)與大腦衰老和認(rèn)知能力下降有關(guān)。試劑盒檢測(cè)范圍為1.563 ng/mL-100 ng/mL，靈敏度為0.611 ng/mL。適用于心血管疾病機(jī)制研究、炎癥相關(guān)動(dòng)物模型評(píng)估、腫瘤微環(huán)境分析等科研場(chǎng)景，為探索VCAM-1在細(xì)胞間通訊、免疫調(diào)控及病理發(fā)展中的功能提供可靠工具本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CD106 ELISA Kit; CD106 Antigen ELISA Kit; INCAM 100 ELISA Kit; INCAM-100 ELISA Kit; L1CAM ELISA Kit; MGC99561 ELISA Kit; V-CAM 1 ELISA Kit; Vascular Cell Adhesion Molecule 1 ELISA Kit; Vascular cell adhesion protein 1 ELISA Kit; VCAM 1 ELISA Kit; VCAM-1 ELISA Kit; VCAM1 ELISA Kit; VCAM1_HUMAN ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    1.563 ng/mL-100 ng/mL
  • 靈敏度：
    0.611 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

     

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays):CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

     

  • 線性度：

     

    To assess the linearity of the assay, samples were spiked with high concentrations of human VCAM-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

  • 標(biāo)準(zhǔn)曲線：

     

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

     

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    VCAM1是細(xì)胞黏附分子，可以在細(xì)胞間發(fā)揮重要的黏附作用。最近的研究表明，VCAM1在免疫調(diào)節(jié)和動(dòng)脈粥樣硬化等疾病的發(fā)展中起著重要的作用。研究表明，VCAM1通過參與炎癥反應(yīng)和免疫細(xì)胞的黏附作用來調(diào)節(jié)免疫系統(tǒng)的功能。此外，VCAM1在心血管疾病中也起著重要的作用，可以作為一種潛在的治療靶點(diǎn)。
  • 功能：
    Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
  • 基因功能參考文獻(xiàn)：
    1. High VCAM1 expression is associated with Cardiovascular Disease. PMID: 28496046
    2. not a specific screening marker for pulmonary arterial hypertension in systemic sclerosis PMID: 29687288
    3. We observed an increase of VCAM-1 urine levels in diabetic nephropathy-basal patients compared to diabetic controls and an increase of urinary neprilysin in DN-treated patients with persistent albuminuria PMID: 29854824
    4. Urinary angiostatin and VCAM-1 are predictive of specific histological changes in concurrent lupus nephritis renal biopsies. PMID: 29076253
    5. In summary, it could be concluded that the expression of gene VCAM-1 was down regulated by taurocholic acid through miR-590-3p and that gene VCAM-1 could participate in the regulation of cell growth, cell proliferation and cell apoptosis PMID: 28851649
    6. VCAM-1 expression is upregulated by CD34+/CD133+-stem cells derived from septic patients PMID: 29601599
    7. Circulating soluble vascular cell adhesion molecule (VCAM-1) level was a useful diagnostic parameter for understanding the difference between coronary artery disease (CAD) and cardiac syndrome X (CSX). PMID: 28675064
    8. findings indicate a novel role for JAK2-V617F in activation of beta1 integrins and enhanced adhesion of granulocytes and 32D myeloid progenitors to VCAM1-coated surfaces PMID: 28096537
    9. High VCAM1 expression is associated with Cardiovascular Disease Risk. PMID: 28202840
    10. VCAM-1 levels are elevated in serum of cystic fibrosis patients. PMID: 28646244
    11. VCAM-1 levels are able to accurately predict significant fibrosis in non-alcoholic fatty liver disease patients PMID: 28461687
    12. These results revealed the effect of CD106 and NF-kappaB in bone marrow failure of Acquired aplastic anemia. PMID: 28764810
    13. Overexpression of LINC00341 suppresses the expression of vascular cell adhesion molecule 1 (VCAM1) and the adhesion of monocytes induced by atheroprone flow and tumor necrosis factor-alpha. PMID: 28500253
    14. Increased expression of PECAM-1, ICAM-3, and VCAM-1 in colonic biopsies from patients with inflammatory bowel disease (IBD) in clinical remission is associated with subsequent flares; this suggests that increases in the expression of these proteins may be early events that lead to flares in patients with IBD PMID: 27552332
    15. Association with the efficiency of hematopoietic stem cells (HSC) mobilization to PB were found in the SNPs of the DGKB gene involved in cell transport and SDF-1-induced migration ability and of the VCAM1 gene which is essential for HSC homing, suggesting that SNPs involved in cell migration ability might be partly involved in HSC PMID: 27839966
    16. sVCAM-1 reflects xerostomia in primary Sjogren's syndrome. sICAM-1 and sE-selectin may be additional parameters of secondary Sjogren's syndrome activity. PMID: 29068581
    17. Augmented expression of endothelial adhesion molecules ICAM1/VCAM1 is involved in the pathophysiology of patients with antiphospholipid syndrome. PMID: 29096830
    18. VCAM-1 knockdown reduced TNFalpha-induced HUVEC migration and tube formation. PMID: 28209985
    19. High levels of serum ICAM-1 was associated with the development of multiple organ failure . High levels of VCAM-1 was associated with both multiple organ failure and in-hospital mortality. PMID: 27701021
    20. VCAM1 protein expression increased in cartilage tissue from spinal tuberculosis patients. PMID: 28829887
    21. This study provided direct evidence that increasing extracellular Ca(2+) enhanced TNF-alpha-induced VCAM-1 activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2/NFkappaB signaling pathway mediating VCAM-1 activation and monocyte adhesion in this pathological process. PMID: 28583863
    22. Findings suggest that sVCAM-1 is related to affective temperaments, and it is a trait marker for liability to mood disorders. This relationship between alterations in cellular adhesion and affective temperament may be important for vulnerability to affective disorders. PMID: 27693464
    23. patients with newly-diagnosed MM have increased serum levels of VCAM-1 and ICAM-1 that correlate with advanced disease features. VCAM-1 is also independently correlated with survival, suggesting an important role in the biology of the disease and supporting its targeting with novel anti-myeloma drugs. PMID: 27232930
    24. VCAM-1 was statistically elevated in major depressive disorder. PMID: 27598970
    25. Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells. PMID: 28122639
    26. Peptide nanoparticles targeting VCAM-1 are suggested as a theranostic carrier for drug delivery to inflamed endothelium. PMID: 27105996
    27. IRF-5 targeted the expression of vascular cell adhesion molecule 1 (VCAM-1) at the transcriptional level by binding to its promoter. PMID: 28818665
    28. In patients with optic neuritis that developed into multiple sclerosis, there was a decrease in serum VCAM-1. PMID: 27806869
    29. There was a negative correlation of miR-126 with the PCI-induced markers of inflammation such as hs-CRP and VCAM-1 PMID: 27900989
    30. this study shows that quercetin reduces the expression of VCAM-1 in oxidized LDL cholesterol-induced endothelial cells PMID: 27585526
    31. Gastrin-releasing peptide (GRP) increased the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) by activating nuclear factor-kappaB (NF-kappaB) in endothelial cells. PMID: 28093230
    32. Mesothelium VCAM-1 expression is negatively associated with progression-free and overall survival in EOC. This is especially compelling in light of previous data suggesting that persistent VCAM-1 expression during treatment is an indicator of platinum resistance. PMID: 28263384
    33. The results of this study suggest that VCAM-1 gene variants may be related to obesity and inflammatory markers in the Korean population PMID: 27853845
    34. Panax notoginseng saponins and Ginsenoside protect aorta form atherosclerosis via Rb1 via activation of Nrf2 and suppression of p38 - VCAM-1 signal pathway. PMID: 27620662
    35. Our results suggest that an impairment in adhesion exists in vitiligo skin, which is supported by the diminished immunohistochemical expression of laminin, beta1 integrin, ICAM-1 and VCAM-1. PMID: 28214208
    36. Th1-induced CD106 expression mediates leukocytes adhesion on synovial fibroblasts from juvenile idiopathic arthritis patients via TNF-alpha. PMID: 27123929
    37. Although the expression of VCAM-1 was higher in adult T-cell leukemia/lymphoma patients individuals, there was no significant difference between the studied groups. PMID: 28110427
    38. Activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in human umbilical vein endothelial cells, consistent with activin A contributing to the pathophysiology of preeclampsia. PMID: 27155341
    39. Statistically significant associations were identified between the chronic periodontal patients and the controls in the gene polymorphisms of rs5498 ICAM-1 (P=0.007) and rs1041163 VCAM-1 (P=0.029). The distribution of rs5498 (P=0.029) and rs1041163 (P=0.049) differed significantly across the mild, moderate, and severe groups of periodontitis. PMID: 27391418
    40. VCAM-1 had a synergistic effect with coronary artery disease on the BDNF PMID: 28131673
    41. findings suggest that the increased levels of IL-17,Hcy and sVCAM contributes contributes to the vascular inflammation and activation presented by sickle cell anemia patients PMID: 26334689
    42. VCAM-1 plays an important role in the development and generation of gestational hypertension. PMID: 27706617
    43. gLDL stimulate the expression of cellular VCAM-1, the secretion of soluble VCAM-1, and the adhesion of monocytes through mechanisms involving p38 MAP kinase and NF-kB signalling pathways activated by RAGE, ERS and oxidative stress, thus contributing to diabetic atherosclerosis. PMID: 27206739
    44. High VCAM1 expression is associated with non-insulin resistant women with polycystic ovary syndrome. PMID: 27245110
    45. Denbinobin inhibited IL-1beta-induced ICAM-1/VCAM-1 expression and monocyte adhesion to osteoarthritis fibroblast-like synoviocytes via mirn146-a PMID: 25052989
    46. Theobroma cacao extract prohibits the increase in IL-6 and sVCAM-1 in endothelial cells induced by plasma from preeclamptic patients. PMID: 26955771
    47. BD patients have a lower expression of ICAM-1, VCAM-1, and E-selectin in their tumor tissues. BD-HDL facilitates the adhesion of tumor cells to vascular endothelium by upregulating the expression of ICAM-1 and VCAM-1, thereby promoting the initial progression of breast cancer metastasis PMID: 26872904
    48. Clopidogrel diminishes TNFalpha-stimulated VCAM-1 expression at least in part via HO-1 induction and CaMKKbeta/AMPK/Nrf2 pathway in endothelial cells. PMID: 26824050
    49. Results show that VCAM1 expression is regulated by TSPO to activate endothelial cells. PMID: 26608360
    50. Human placental, chorionic villi-derived mesenchymal stem cells expressing VCAM-1 promote angiogenesis in a mouse ischemia model. PMID: 27044487

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12663

    OMIM: 192225

    KEGG: hsa:7412

    STRING: 9606.ENSP00000294728

    UniGene: Hs.109225