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  4. Human WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2(WFIKKN2) ELISA kit

Human WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2(WFIKKN2) ELISA kit

  • 中文名稱：
    人WAP，kazal，免疫球蛋白，kunitz和NTR結(jié)構(gòu)域蛋白2(WFIKKN2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL026099HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人WAP，kazal，免疫球蛋白，kunitz和NTR結(jié)構(gòu)域蛋白2(WFIKKN2)酶聯(lián)免疫試劑盒（CSB-EL026099HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的WFIKKN2含量。WFIKKN2是一種新的TGF-β家族成員的胞外結(jié)合蛋白，高表達于卵巢和睪丸，與TGF-β家族成員如MSTN、GDF11、TGF-β1、BMP2和BMP4等結(jié)合，通過調(diào)節(jié)這些因子的功能來正向或負向調(diào)控生殖細胞發(fā)生。其具體作用機制涉及阻斷SMAD信號通路，激活非經(jīng)典途徑，以及與生殖細胞發(fā)育相關(guān)。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，靈敏度為7.81 pg/mL。適用于細胞生物學(xué)、分子病理學(xué)等科研領(lǐng)域，可應(yīng)用于炎癥相關(guān)疾病模型、腫瘤微環(huán)境研究或發(fā)育生物學(xué)中WFIKKN2蛋白表達動態(tài)監(jiān)測，為探索其分子功能提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    WFIKKN2 ELISA Kit; GASP1 ELISA Kit; WFIKKNRP ELISA Kit; UNQ9235/PRO31996 ELISA Kit; WAP ELISA Kit; Kazal ELISA Kit; immunoglobulin ELISA Kit; Kunitz and NTR domain-containing protein 2 ELISA Kit; Growth and differentiation factor-associated serum protein 1 ELISA Kit; GASP-1 ELISA Kit; hGASP-1 ELISA Kit; WAP ELISA Kit; follistatin ELISA Kit; immunoglobulin ELISA Kit; Kunitz and NTR domain-containing-related protein ELISA Kit; WFIKKN-related protein ELISA Kit
  • 縮寫：
    WFIKKN2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.8 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin.
  • 基因功能參考文獻：
    1. WFIKKN2 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed higher levels of GASP-1 while postmenopausal women using HT showed a significant increased expression over controls. PMID: 22395277
    3. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). PMID: 20026378
    4. Newly discovered WFIKKNPR gene structure and tissue distribution of gene expression is commpared with that of the WFIKKN gene in adult and fetal tissues and organs PMID: 11928817
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    WFIKKN family
  • 組織特異性：
    Primarily expressed in ovary, testis and brain, but not in liver. In fetal tissues, it is primarily expressed in brain, skeletal muscle, thymus and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30916

    OMIM: 610895

    KEGG: hsa:124857

    STRING: 9606.ENSP00000311184

    UniGene: Hs.211475