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  4. Human adrenomedullin 2 (ADM2) ELISA kit

Human adrenomedullin 2 (ADM2) ELISA kit

  • 中文名稱：
    人腎上腺髓質(zhì)素2(ADM2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL001371HU
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人腎上腺髓質(zhì)素2(ADM2)酶聯(lián)免疫試劑盒（CSB-EL001371HU）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織培養(yǎng)上清液樣本中的ADM2含量。人腎上腺髓質(zhì)素2（ADM2）是一種小分子活性肽，作為心血管、腎臟、肺臟等重要臟器的內(nèi)源性保護(hù)因子，參與機(jī)體內(nèi)環(huán)境穩(wěn)態(tài)的調(diào)節(jié)，具有降低血壓、減輕炎癥、保護(hù)心肌和肺功能等作用。研究顯示，ADM2通過IGF-II信號(hào)通路修復(fù)血腦屏障，對(duì)焦慮障礙及相關(guān)精神疾病的治療提供新的潛在靶點(diǎn)。試劑盒檢測(cè)范圍為31.25 pg/mL-2000 pg/mL，本產(chǎn)品適用于科研領(lǐng)域中對(duì)ADM2表達(dá)調(diào)控機(jī)制的探索，如代謝性疾病動(dòng)物模型的血漿檢測(cè)、體外細(xì)胞實(shí)驗(yàn)中分泌水平的動(dòng)態(tài)監(jiān)測(cè)，或藥物干預(yù)下ADM2生物標(biāo)志物變化的評(píng)估，為心血管及代謝相關(guān)的基礎(chǔ)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ADM2 ELISA Kit; ADM2_HUMAN ELISA Kit; Adrenomedullin 2 ELISA Kit; AM2 ELISA Kit; dJ579N16.4 ELISA Kit; FLJ21135 ELISA Kit; IMDL ELISA Kit; IMDS ELISA Kit; Intermedin ELISA Kit; Intermedin-long ELISA Kit; Intermedin-short ELISA Kit
  • 縮寫：
    ADM2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates
  • 檢測(cè)范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.8 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ADM2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %93
    Range %87-99
    1:2Average %98
    Range %93-103
    1:4Average %84
    Range %81-89
    1:8Average %89
    Range %83-95
  • 回收率：
    The recovery of human ADM2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 10197-107
    EDTA plasma (n=4)9289-96
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    20002.988 3.036 3.012 2.874
    10002.365 2.488 2.427 2.289
    5001.609 1.675 1.642 1.504
    2500.901 0.909 0.905 0.767
    1250.545 0.525 0.535 0.397
    62.50.375 0.389 0.382 0.244
    31.250.278 0.258 0.268 0.130
    00.135 0.140 0.138
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.; May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
  • 基因功能參考文獻(xiàn)：
    1. IMD may be an important self-protective factor in response to sepsis. PMID: 29980671
    2. The plasma ADM2 levels were inversely correlated with obesity in humans, and adipo-ADM2-transgenic (tg) mice displayed resistance to high-fat diet-induced obesity with increased energy expenditure. PMID: 27621315
    3. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
    4. ADM-2 is a stress-inducible gene controlled by ATF-4. PMID: 27328454
    5. Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho via the calcitonin receptor/modifying protein complex and protein kinase A signaling. PMID: 26880455
    6. Intermedin (IMD) derived from human cardiac microvascular endothelial cell and acting in a paracrine manner on cardiomyocytes, predominantly at AM1 receptors, is more likely to contribute to direct protection by endogenous IMD of cardiomyocytes against acute ischemia reperfusion injury. PMID: 26743504
    7. Elevated plasma intermedin levels are independently associated with long-term recurrence and distant metastasis of prostate cancer. PMID: 26406405
    8. ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 and decreasing MUC1 expression to facilitate trophoblast invasion. PMID: 26510869
    9. Plasma intermedin and BNP levels were markedly higher in acute coronary syndrome patients than in healthy people. PMID: 23391507
    10. High levels of ADM2 expression predict a poorer survival in patients with pancreatic adenocarcinoma. PMID: 25982376
    11. TSH induced AM2/IMD expression in the thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries. PMID: 25102228
    12. Intermedin affects the endothelial cell junction and blood vessel sprouting in a VE-cadherin dependent way. PMID: 25637664
    13. results suggest that high plasma intermedin level is associated with poor outcomes of patients and may be a useful prognostic biomarker in ST-segment elevation acute myocardial infarction. PMID: 24969626
    14. ADM and IMD mRNA expression are elevated in chronic heart failure at different stages of the disease. PMID: 24531032
    15. a significant increase in plasma intermedin following acute myocardial infarction may be associated with oxidative stress, and could be used as a marker to reflect the severity of the coronary stenosis PMID: 23499766
    16. this study is the first to demonstrate a potential involvement of IMD in human embryo implantation and placental development via regulation of trophoblast invasion at the maternal-fetal interface PMID: 23337723
    17. Intermedin plays a critical role in the vascular remodeling process and tumor angiogenesis by regulating vascular endothelial-cadherin and extracellular signal-regulated kinase. PMID: 22922959
    18. adm2 polymorphism is associated with renal dysfunction, blood pressure regulation and asymptomatic cerebrovascular diseases in the Japanese general population PMID: 21832999
    19. potentially involved in regulating HLA-G antigen at the maternal-fetal interface and facilitating trophoblast invasion and migration via MAPK3/1 phosphorylation PMID: 21816853
    20. Data showed that intermedin (IMD)/adrenomedullin 2 (ADM2) is a novel oocyte-derived ligand important for the regulation of cell interactions in COCs that functions, in part, by suppressing cumulus cell apoptosis. PMID: 22009752
    21. Intermedin reduces HUVEC permeability via Rac1-mediated actin cytoskeleton rearrangement. PMID: 21816966
    22. Adrenomedullin-related peptide, AM2 was highly expressed in colorectal cancer tissue. The percent increase of AM2 synthesis in cancer tissues to the surrounding normal tissues was greater than adrenomedullin. PMID: 21839130
    23. IMD may be an endogenous vasoprotective factor for vascular calcification PMID: 19910445
    24. may have a role in the physiology of human pregnancy via regulation of trophoblast invasion and migration PMID: 19535789
    25. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes PMID: 14615490
    26. ADM2 may be related to the central and peripheral regulation of the circulation and water-electrolyte metabolism PMID: 16359754
    27. IMD expressed by pericytes in has a role in susceptibility of the skin of atopic dermatitis patients to inflammatory stimuli PMID: 17008878
    28. Study has shown expression of AM2/IMD in various types of cells in the central nervous system and the cardiovascular system, and suggested possible (patho)physiological roles of AM2/IMD in these systems. PMID: 17346853
    29. robust increase in expression of the peptide in hypertrophied and ischaemic myocardium indicates an important protective role for adrenomedullin 2 as an endogenous counter-regulatory peptide in the heart--REVIEW PMID: 17965749
    30. adrenomedullin 2/intermedin may have autocrine/paracrine regulatory roles in adrenal tumors and attached non-neoplastic adrenal tissues, such as tumor growth. PMID: 18460550
    31. Vascular injury in rat kidney is reduced by IMD gene delivery and it prevents glomerular and peritubular capillary loss. PMID: 18829738
    32. Data show that adrenomedullin-2 was shown to be secreted by HAEC and may play a potential protective role in human aortic endothelial cells. PMID: 19255504
    33. IMD enhances angiogenesis through ERK, Akt/NOS/NO, and VEGF/VEGFR-2 signaling pathways PMID: 19592612
    34. IMD is a novel hypoxia-induced gene and a potential interventional agent for the improvement of endothelial barrier function in systemic inflammatory responses and hypoxia-induced vascular leakage. PMID: 19684198

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Adrenomedullin family
  • 組織特異性：
    Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28898

    OMIM: 608682

    KEGG: hsa:79924

    STRING: 9606.ENSP00000379086

    UniGene: Hs.449099