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  4. Human beta cellulin,BTC ELISA Kit

Human beta cellulin,BTC ELISA Kit

  • 中文名稱：
    人β細(xì)胞素(BTC)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E04506h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人β細(xì)胞素(BTC)酶聯(lián)免疫試劑盒（CSB-E04506h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的BTC含量。人β細(xì)胞素（BTC）是表皮生長因子（EGF）家族成員，主要在胰腺中表達(dá)，調(diào)節(jié)β細(xì)胞生長和分化。BTC通過結(jié)合EGFR和ERBB4受體，激活PI3K/Akt和RAS/RAF/MEK/Erk信號通路，促進(jìn)β細(xì)胞增殖和胰島素分泌，在糖尿病治療中具有潛在應(yīng)用價值。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL，該產(chǎn)品為研究BTC在代謝性疾病、糖尿病發(fā)病機(jī)制、組織再生等領(lǐng)域的生物學(xué)功能提供可靠工具，血清樣本適用于循環(huán)系統(tǒng)中BTC水平的動態(tài)監(jiān)測，組織勻漿檢測則可用于探究局部組織表達(dá)特征?？蒲腥藛T可通過評估不同實(shí)驗(yàn)條件下BTC的表達(dá)變化，為相關(guān)信號通路研究及潛在治療靶點(diǎn)探索提供數(shù)據(jù)支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    BTCProbetacellulin [Cleaved into: Betacellulin ELISA kit; BTC)] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    0.156 ng/mL-10 ng/mL
  • 靈敏度：
    0.039 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
  • 基因功能參考文獻(xiàn)：
    1. Our results suggest that betacellulin induces ovarian cancer migration and Slug-dependent E-cadherin down-regulation PMID: 27129169
    2. CXCL8 production from lung cancer cells could be initiated by an autocrine mechanism or external sources of BTC. PMID: 24629040
    3. Data suggest that BTC (betacellulin), AREG (amphiregulin), and EREG (epiregulin) induced prostaglandin E2 production by induction of COX-2 (prostaglandin-endoperoxide synthase 2) through MAP kinase signaling in granulosa cells. PMID: 24092824
    4. BTC has properties of increasing retinal vascular leakage that could contribute to the development of diabetic retinopathy. PMID: 22183345
    5. Data suggest a novel receptor-independent role for betacellulin intracellular-domain fragment signaling due to its ability to inhibit cell growth in vitro. PMID: 20530572
    6. These are the first data that demonstrate an influence of betacellulin upon mesenchymal stem cells and the first to implicate HIF-alpha in betacellulin-mediated proliferation. PMID: 20165885
    7. The solution structure of the EGF-like domain of betacellulin has been determined using two-dimensional nuclear magnetic resonance spectroscopy PMID: 12074582
    8. The main structural properties of the model and the templates are compared and the hBTC conformation is closely similar to that of hTGFalpha. PMID: 12111392
    9. Betacellulin and heregulin/NDF-alpha are involved in epidermal morphogenesis and/or in maintenance of the differentiated phenotype. PMID: 12768307
    10. although BTC and EGF share overlapping signaling properties, the ability of BTC to enhance Erk activation occurs independent of Ras. PMID: 15192046
    11. BTC may play a pivotal role as a local growth factor in promoting the differentiated villous trophoblastic function via ErbB-1 in early placentas and in contributing to placental growth through EVT cell function via ErbB-4 in term placentas. PMID: 15248827
    12. Betacellulin is expressed in malignant fibrous histiocytoma and is a regulator of tumor growth. PMID: 15274392
    13. shedding of precursor is mediated by ADAM10 PMID: 15507448
    14. To determine if mutations in the betacellulin gene play a role in the development of type 2 diabetes, we screened subjects with type 2 diabetes for the presence of mutations. PMID: 15793259
    15. Genetic variations in the protein-coding region of the human BTC gene are unlikely to be a major contributor to development of type 2 diabetes. PMID: 15936459
    16. -226A/G polymorphism of the BTC gene may contribute to the development of diabetes. PMID: 16306376
    17. intron 4 T-4 allele in the betacellulin gene is associated with lower risk of type 1 diabetes mellitus and may interact with human leukocyte antigen PMID: 16683131
    18. Failure to confirm a role for nonsynonymous coding variants of betacellulin in the propensity to type 2 diabetes or to impaired insulin secretion in African American subjects. PMID: 16869959
    19. Variants in the betacellulin gene do not play a major role in the development of type 2 diabetes in an Amish Caucasian populations PMID: 17479438
    20. the ADAM10 prodomain inhibits betacellulin shedding, demonstrating that it could be of potential use as a therapeutic agent to treat cancer. PMID: 17895248
    21. 1st report of BTC expression in breast cancer. Its expression was lower in lobular breast cancers than in ductal carcinomas. PMID: 17962208
    22. These results indicate the possibility of designing BTC mutants, which have an activity of inducing differentiation only, without facilitating growth promotion. PMID: 18508082
    23. In vivo, EGFR signaling is hyperactive in tumor cells of skin SCC but not of BCC, and in nearby asymptomatic epidermis of both tumor types. Hyperactivation is due to upregulation of EGFR ligands AREG, HBEGF and TGFA, and downregulation of BTC PMID: 17525275

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  • 亞細(xì)胞定位：
    [Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1121

    OMIM: 600345

    KEGG: hsa:685

    STRING: 9606.ENSP00000379092

    UniGene: Hs.591704