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  4. Human collectin sub-family member 11,COLEC11 ELISA Kit

Human collectin sub-family member 11,COLEC11 ELISA Kit

  • 中文名稱：
    人集蛋白亞家族成員11(COLEC11)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E11839h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人集蛋白亞家族成員11(COLEC11)酶聯(lián)免疫試劑盒（CSB-E11839h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的COLEC11含量。COLEC11是一個重要靶點。它在人體生理過程中可能起到關(guān)鍵作用。研究機制方面，可能與相關(guān)的免疫反應(yīng)、細(xì)胞信號傳導(dǎo)等存在關(guān)聯(lián)，但目前具體的作用過程和細(xì)節(jié)還需進(jìn)一步深入研究，以明確其在疾病發(fā)生發(fā)展中的角色和潛在治療價值。試劑盒檢測范圍為0.156 ng/ml-10 ng/ml，適用于科研領(lǐng)域中對 COLEC11 表達(dá)水平的動態(tài)監(jiān)測，例如探究感染、炎癥或遺傳性疾病模型中該蛋白的生物學(xué)功能及調(diào)控機制。支持研究者深入探索 COLEC11 在體液中的分布特征及其與病理生理過程的相關(guān)性，為免疫學(xué)、分子生物學(xué)及疾病機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CL K1 ELISA Kit; CL K1 I ELISA Kit; CL K1 II ELISA Kit; CL K1 IIa ELISA Kit; CL K1 IIb ELISA Kit; CL-K1 ELISA Kit; CLK1 ELISA Kit; COL11_HUMAN ELISA Kit; COLEC 11 ELISA Kit; COLEC11 ELISA Kit; Collectin 11 ELISA Kit; Collectin kidney I ELISA Kit; Collectin kidney protein 1 ELISA Kit; Collectin sub family member 11 ELISA Kit; Collectin-11 ELISA Kit; Collectin11 ELISA Kit; DKFZp686N1868 ELISA Kit; MGC129470 ELISA Kit; MGC129471 ELISA Kit; MGC3279 ELISA Kit
  • 縮寫：
    COLEC11
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    0.156 ng/ml-10 ng/ml
  • 靈敏度：
    0.039 ng/ml.
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human COLEC11 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 86  
    Range % 80-92  
    1:2 Average % 99  
    Range % 91-110  
    1:4 Average % 97  
    Range % 92-105  
    1:8 Average % 93  
    Range % 90-98  
  • 回收率：
    The recovery of human COLEC11 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 96 89-100  
    EDTA plasma (n=4) 90 86-96  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    10 2.649 2.462 2.556 2.433  
    5 2.167 2.054 2.111 1.988  
    2.5 1.477 1.385 1.431 1.308  
    1.25 0.821 0.789 0.805 0.682  
    0.625 0.450 0.432 0.441 0.318  
    0.312 0.278 0.269 0.274 0.151  
    0.156 0.207 0.202 0.205 0.082  
    0 0.124 0.121 0.123 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis.
  • 基因功能參考文獻(xiàn)：
    1. this study demonstrates the role of CL-11 and the molecular mechanisms involved in modulating retinal pigment epithelial cell phagocytosis and cytokine production PMID: 28772263
    2. High CLK1 expression is associated with cardiovascular disease. PMID: 27341702
    3. The exclusion of the MASP1 and COLEC11 Loci in two individuals from different consanguineous families and the absence of mutations in four further individuals sequenced for both genes raises the possibility that that there is further genetic heterogeneity of 3MC syndrome PMID: 26789649
    4. identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial mannose-capped lipoarabinomannan as a primary ligand for CL-LK PMID: 26173080
    5. Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. PMID: 26154564
    6. promoter polymorphism COLEC11-9570C>T (rs3820897) was associated with decreased levels of CL-K1. PMID: 25710878
    7. the sugar specificity of CL-K1 was established. PMID: 25912189
    8. These results suggest that specific diseases may affect CL-K1 synthesis in an organ dependent manner and that elevated plasma CL-K1 levels are associated with the presence of DIC. PMID: 24474086
    9. Most plasma CL-K1 was found in complex with CL-L1 in a ratio suggesting a heteromeric subunit of 1 CL-L1 & 2 CL-K1 polypeptides. It associated with MASPs 1, 2 & 3. On binding mannan or DNA in the presence of MASP-2, the complex deposited C4b. PMID: 24174618
    10. Data suggest that collectin 11 (CL-11), e.g. via complement, may play a role in response to particles and surfaces presenting extracellular DNA, such as apopototic cells. PMID: 23954398
    11. collectin-11 associates with all the known MBL-associated serine proteases (MASP-1, MASP-2 and MASP-3) as well as the lectin complement pathway regulator MAP-1. PMID: 23220946
    12. Data show that the concentration of collectin kidney 1 (CL-K1, COLEC11) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL) was 1.72 +/- 1.51 microg/ml. PMID: 21893516
    13. these findings demonstrate a role for complement pathway factors in fundamental developmental processes and in the etiology of 3MC syndrome. PMID: 21258343
    14. CL-11 plays a role in activation of the complement system and in the defense against invading microorganisms PMID: 20956340

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  • 相關(guān)疾?。?/div>
    3MC syndrome 2 (3MC2)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    COLEC10/COLEC11 family
  • 組織特異性：
    Ubiquitous. Detected in adrenal gland, kidney, liver, ovaries and testis (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17213

    OMIM: 265050

    KEGG: hsa:78989

    STRING: 9606.ENSP00000339168

    UniGene: Hs.32603