搡老女人多毛老妇女中国,日韩亚洲欧美中文高清在线,人妻少妇一区二区三区,色妞色综合久久夜夜,日本熟妇xxxx

  1. 首頁
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Human eosinophil granule major basic protein (EMBP/MBP) ELISA Kit

Human eosinophil granule major basic protein (EMBP/MBP) ELISA Kit

  • 中文名稱：
    人嗜伊紅顆粒主要堿性蛋白(EMBP/MBP)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E17578h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人嗜伊紅顆粒主要堿性蛋白(EMBP/MBP)酶聯(lián)免疫試劑盒（CSB-E17578h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的PRG2含量。PRG2即嗜酸性粒細(xì)胞蛋白酶2，在過敏反應(yīng)、寄生蟲感染等免疫防御中發(fā)揮作用。其研究機(jī)制涉及與炎癥介質(zhì)相互作用、介導(dǎo)細(xì)胞信號(hào)傳導(dǎo)等。對(duì)它的研究有助于了解相關(guān)疾病發(fā)病機(jī)制，也為開發(fā)靶向治療藥物提供潛在靶點(diǎn)。試劑盒檢測(cè)范圍為1.3 ng/ml- 1000 ng/ml，適用于科研場(chǎng)景中探索嗜酸性粒細(xì)胞活化機(jī)制、評(píng)估過敏性疾病的生物標(biāo)志物水平、監(jiān)測(cè)寄生蟲感染免疫應(yīng)答動(dòng)態(tài)，或用于藥物開發(fā)過程中炎癥調(diào)節(jié)效果的體外評(píng)價(jià)，為免疫病理學(xué)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    PRG2; MBP; Bone marrow proteoglycan; BMPG; Proteoglycan 2
  • 縮寫：
    PRG2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    1.3 ng/ml - 1000 ng/ml
  • 靈敏度：
    1.3 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 線性度：
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA.
  • 基因功能參考文獻(xiàn)：
    1. Low PRG2 expression is associated with drug resistance in Chronic myeloid leukemia. PMID: 29936783
    2. MBP-1 aggregation is important for innate immunity and immunopathology mediated by eosinophils.MBP-1 toxicity is restrained via crystallization in eosinophil secretory granules. PMID: 25728769
    3. free protein in nasal mucus can be used as a biomarker to diagnose chronic rhinosinusitis PMID: 25266917
    4. mRNA levels of eosinophil granule proteins, rather than sputum eosinophil%, may reflect airway hyperresponsiveness and airflow limitation. PMID: 24814827
    5. This protein contains a peptide that displays strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. PMID: 319906
    6. Eosinophil major basic protein activates human cord blood mast cells primed with fibroblast membranes by integrin-beta1. PMID: 24112102
    7. During pregnancy, the proform of eosinophil major basic protein-angiotensinogen constitutes the major form in late pregnancy. PMID: 23033876
    8. Combinations of respiratory syncytial virus and MBP synergistically induced cell death in pulmonary alveolar epithelial cells (A549). PMID: 20977431
    9. The expression of MBP in nasal mucus obtained from chronic rhinosinusitispatients was obviously higher than that of nasal mucus obtained from controls. PMID: 18720885
    10. MBP and NE collaborated to cause the pathological effects of nasal polyps. PMID: 18476621
    11. novel transcript was alternatively transcribed from intron III of the ENO1 gene and was feasible for MBP-1 production PMID: 20849415
    12. The proMBP is a novel first trimester serum marker for adverse pregnancy outcome. PMID: 19626619
    13. Transcription is regulated by novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms. PMID: 12202480
    14. IGF bioactivity is regulated by reversible cell surface binding of PAPP-A, which in turn is regulated by proMBP PMID: 12370176
    15. MBP's structure is described, and its ability to bind to pregnancy-associated plasma protein A explained PMID: 12421832
    16. Deposits of eosinophilic MBP are found on the surface of eosinophils and damaged muscle fibers surrounded by eosinophils in patients with idiopathic eosinophilic myositis. PMID: 12534990
    17. MBP stimulates a Src kinase-dependent activation of class I(A) phosphoinositide 3-kinase and, in turn, activation of protein kinase C zeta in neutrophils, which contributes to the activation of NADPH oxidase and resultant superoxide production. PMID: 14500673
    18. Proform of MPB forms a covalent complex with PAPPA in which PAPPA is inhibited. PMID: 14988014
    19. the proform of eosinophil major basic protein inhibits the proteolytic activity of PAPP-A PMID: 15647258
    20. two regions shown previously to contain the cytotoxic and cytostimulatory properties of MBP are accessible for ligand interaction in cell surface-bound MBP PMID: 16940047
    21. Compared to MBP1, which is present in eosinophils, basophils, and a human mast cell line, homologous MBP2 is present only in eosinophils and may be a useful biomarker for eosinophil-associated diseases. PMID: 17082653
    22. Pregnancy-associated plasma protein A is involved in processes preceding vulnerable plaque development in acute coronary syndrome. PMID: 17223728
    23. knockdown of endogenous MBP-1 is involved in cellular senescence of HFF through p53-p21 pathway. PMID: 18852884
    24. No variation in genes major basic protein for Atopic dermatitis pathogenesis in this German cohort PMID: 19014520
    25. The significantly elevated levels of proMBP in myelofibrosis patients implies that proMBP could be an important stromal cytokine in bone marrow fibrosis. PMID: 19039208
    26. addition to granule-stored MBP, even unstimulated eosinophils contained appreciable amounts of MBP within secretory vesicles PMID: 19398958

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Bone marrow proteoglycan]: Secreted. Note=The proform is secreted.; [Eosinophil granule major basic protein]: Cytoplasmic vesicle, secretory vesicle. Note=The proform is secreted. The mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core).
  • 組織特異性：
    High levels of the proform in placenta and pregnancy serum; in placenta, localized to X cells of septa and anchoring villi. Lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow and co
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9362

    OMIM: 605601

    KEGG: hsa:5553

    STRING: 9606.ENSP00000312134

    UniGene: Hs.512633