Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.

1. The LFA-1-ICAM-1 orientation described here with ICAM-1 pointing anti-parallel to the LFA-1 beta-subunit leg is the same orientation that would be stabilized by tensile force transmitted between the ligand and the actin cytoskeleton and is consistent with the cytoskeletal force model of integrin activation. PMID: 29507098
2. LncRNA ITGB2-AS1 could promote the migration and invasion of breast cancer cells by up-regulating ITGB2. PMID: 29941860
3. Overexpression of ITGB2 was not correlated with ITGB2 promoter hypomethylation in systemic sclerosis. PMID: 29356883
4. actin engagement produces tension within the beta2 subunit to induce and stabilize an active integrin conformational state and that this requires intact talin and kindlin motifs. PMID: 27721490
5. on tumour-infiltrating T-lymphocytes, galectin prevents the formation of a functional secretory synapse by preventing optimal LFA-1 triggering PMID: 27447355
6. exploration of the underlying mechanism demonstrated that ICAM3 not only binds to LFA-1 with its extracellular domain and structure protein ERM but also to lamellipodia with its intracellular domain which causes a tension that pulls cells apart (metastasis). PMID: 29729315
7. vesicle-associated RhoB is a regulator of the Rab11-mediated recycling of LFA-1 to the cell surface, an event that is necessary for T lymphocyte motility. PMID: 29233918
8. The ITGB2 variant rs2230531 was examined in an independent cohort of Tasmanian patients with hematologic malignancies (HM) to see if its presence correlated with chronic lymphocytic leukemia. The variant was found in several lymphoid and myeloid HMs, so if contributes to the risk of HM, it does so broadly across HM subtypes in this population. PMID: 28490571
9. an integrated strategy of whole genome and transcriptome analysis enabled identification of LB-ITGB2-1 as HLA-B*15:01-restricted MiHAs encoded by an alternative transcript. The alternative ITGB2 transcript was shown to be expressed in leukemic cells of different origins. PMID: 26964570
10. Neutrophil rolling over E-selectin at precise shear stress transmits tension and catch-bond formation with L-selectin via sLe(x), resulting in focal clusters that deliver a distinct signal to upshift beta2-integrins to a high-affinity state. Rivipansel effectively blocked formation of selectin catch-bonds, revealing a novel mechanotransduction circuit PMID: 28811304
11. CD177 signals in a beta2 integrin-dependent manner to orchestrate a set of activation-mediated mechanisms that impair human neutrophil migration. PMID: 28807980
12. findings suggest the partitioning in soluble CD18 to reflect a compensatory anti-inflammatory response syndrome and hyperinflammation, respectively, manifested as part of sepsis. PMID: 28714582
13. activation of LFA-1 (alphaLbeta2) and Mac-1 (alphaMbeta2), two subfamilies of integrin beta2 complexes, on human primary monocytes following platelet releasate treatment PMID: 27690452
14. data suggest that regulation of LFA-1 is one reason for the different activity of NK cells during differentiation PMID: 28100681
15. The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta binding site that modulates integrin alphaM(PS)beta2 outside-in signaling PMID: 27974454
16. this study shows that cross-talk between LFA-1 and Notch1 through the Akt/ERK-GSK3beta signaling enhances T cell differentiation toward Th1 PMID: 27206767
17. The results show that with LFA-1 antibodies, we can activate LFA-1 and inhibit alpha4beta1, inhibit both LFA-1 and alpha4beta1, inhibit LFA-1 but not alpha4beta1, or not affect LFA-1 or alpha4beta1 PMID: 27443292
18. K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1. PMID: 28052935
19. Genetic inactivation and blockade studies revealed that homophilic interactions between intercellular adhesion molecule 1 (ICAM-1) expressed on tumor cells and MSCs, respectively, regulate the competition between tumor cells and HSPCs for binding to MSCs. Moreover, tumor cell-secreted soluble ICAM-1(sICAM-1) also impaired HSPC adhesion via blocking CD18-ICAM-1 binding between HSPCs and MSCs PMID: 27207667
20. The ability of simvastatin to target CR3 in its ligand binding-activated conformation is a novel mechanism to explain the known anti-inflammatory effects of this compound, in particular because this CR3 conformation is found in pro-inflammatory environments. PMID: 27339893
21. CD18 methylation and age greater than 65 years were independent prognostic factors of thrombosis complicated by primary myelofibrosis. PMID: 27595148
22. our study highlights the difficulties with the sole use of CD18 for the diagnosis of LAD-1. PMID: 26434744
23. genetic polymorphism is associated with leukocyte adhesion deficiency type 1 in Iranian families PMID: 26639818
24. Critical role of the Mac1/NOX2 pathway in mediating reactive microgliosis-generated chronic neuroinflammation and progressive neurodegeneration PMID: 26498406
25. Contact-activated C3(H2O) is a novel ligand for CD11b/CD18 that mediates platelet-PMN complex formation and the binding of platelet-derived microparticles to PMNs. PMID: 26293614
26. The expression level of Mac-1 correlated with the number of neutrophils in patients with serous, endometrioid and undifferentiated epithelial ovarian cancer. PMID: 26563750
27. Rerefined beta2 integrin structures show pyroglutamic acid at the beta2 N terminus and bending within the EGF1 domain. Allostery is relayed to the alphaI domain by an internal ligand binding to a pocket at the interface between the beta-propeller and betaI domains. PMID: 26936951
28. Four new mutations in the ITGB2 gene were found. These results can be used for decisive genetic diagnosis, genetic counseling, as well as prenatal diagnosis for all patients who are suspended to Leukocyte adhesion deficiency type I (LAD-I). PMID: 26497373
29. Contact-dependent lung adenocarcinoma aggregate dispersion by M2a macrophages occurs via ICAM-1 and beta2 integrin interactions. PMID: 26231039
30. specific LFA-1 binding partners that may play a role in regulating LFA-1 activity in dendritic cells. PMID: 26889827
31. The blood levels of CD18 soluble form were decreased in chronic rheumatoid arthritis patients. PMID: 26849368
32. Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (downstream of tyrosine kinase 1) (Dok1) interaction. PMID: 26108885
33. Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo PMID: 26468229
34. Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall. PMID: 26188538
35. The mechanism responsible for this negative regulation exerted by CD9 on LFA-1 adhesion does not involve changes in the affinity state of this integrin but seems to be related to alterations in its state of aggregation. PMID: 26003300
36. Case Report: recurrent pyoderma gangrenosum and cystic acne associated with leucocyte adhesion deficiency due to novel mutations in ITGB2 successfully treated with infliximab/adalimumab. PMID: 24995649
37. Nine novel mutations in CD18 in 15 patients and 11 known mutations in 16 patients with leukocyte adhesion deficiency-I were detected. PMID: 25703682
38. Stable clutch formation was observed for Mn(2+)-induced high affinity LFA-1, but was not required for physiological adhesion PMID: 26143530
39. TL1A increases expression of CD25, LFA-1, CD134 and CD154, and induces IL-22 and GM-CSF production from effector CD4 T-cells PMID: 25148371
40. Priming by CCL21 restricts lateral mobility of the adhesion receptor LFA-1 and restores adhesion to ICAM-1 nanoaggregates on human mature dendritic cells. PMID: 24945611
41. 16 novel missense mutations in the beta2 integrin subunit have been characterized. PMID: 25514840
42. In addition to LFA-1, this work reveals a second surface protein, Fas, that is critical for LtxA-mediated cell death. PMID: 25850729
43. CD18 expression correlated positively with eosinophil numbers in the esophagus of patients with eosinophilic esophagitis. PMID: 24870064
44. the coordinated expression of LFA-1 and DNAM-1 is a central component of NK cell education and provides a potential mechanism for controlling cytotoxicity by functionally mature NK cells. PMID: 25825444
45. A signaling network stimulated by beta2 integrin promotes the polarization of lytic granules in cytotoxic cells. PMID: 25292215
46. The positive correlation is established between content of polymorphic nuclear monocytes and level of expression of molecules of LFA-1, ICAM-1, LFA-3, and PECAM-1. PMID: 25884075
47. The level of LFA-1 expression on allergic asthma patient peripheral blood mononuclear cells (PBMCs) was greater than on healthy PBMCs. PMID: 25341726
48. The data provide direct support for a model in which the T cell actin network generates mechanical forces that regulate LFA-1 activity at the immunological synapse. PMID: 25666810
49. Our results showed that alphaLbeta2 with alphaM calf-1 domain completely lost the response to Mg/EGTA activation. PMID: 25640842
50. PTPRG is a JAK2 phosphatase that negatively regulates leukocyte integrin beta2 activation. PMID: 25624455

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Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.

Integrin beta chain family

Leukocytes. Expressed in neutrophils (at protein level).

HGNC: 6155

OMIM: 116920

KEGG: hsa:3689

STRING: 9606.ENSP00000303242

UniGene: Hs.375957