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  4. Human inter-alpha-trypsin inhibitor heavy chain H1(ITIH1) ELISA Kit

Human inter-alpha-trypsin inhibitor heavy chain H1(ITIH1) ELISA Kit

  • 中文名稱：
    人間α-胰蛋白酶抑制因子重鏈H1(ITIH1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E13743h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人間α-胰蛋白酶抑制因子重鏈H1(ITIH1)酶聯(lián)免疫試劑盒（CSB-E13743h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液、尿液、組織勻漿樣本中的ITIH1含量。試劑盒檢測范圍為15.6 ng/mL-1000 ng/mL，本試劑盒可應(yīng)用于基礎(chǔ)醫(yī)學(xué)研究中ITIH1的生物學(xué)功能解析、炎癥相關(guān)疾病模型的分子機(jī)制探索，以及藥物干預(yù)對細(xì)胞外基質(zhì)重塑影響的體外評價(jià)等科研場景。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    H1P ELISA Kit; IATIH ELISA Kit; IGHEP1 ELISA Kit; Inter alpha (globulin) inhibitor H1 ELISA Kit; Inter alpha (globulin) inhibitor H1 polypeptide ELISA Kit; Inter alpha trypsin inhibitor heavy chain 1 ELISA Kit; Inter alpha trypsin inhibitor heavy chain H1 ELISA Kit; Inter-alpha-inhibitor heavy chain 1 ELISA Kit; Inter-alpha-trypsin inhibitor complex component III ELISA Kit; Inter-alpha-trypsin inhibitor heavy chain H1 ELISA Kit; ITI heavy chain H1 ELISA Kit; ITI-HC1 ELISA Kit; ITIH ELISA Kit; ITIH1 ELISA Kit; ITIH1_HUMAN ELISA Kit; Serum-derived hyaluronan-associated protein ELISA Kit; SHAP ELISA Kit
  • 縮寫：
    ITIH1
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates, urine, tissue homogenates
  • 檢測范圍：
    15.6 ng/mL-1000 ng/mL
  • 靈敏度：
    3.9 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human ITIH1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:100Average %86
    Range %80-92
    1:200Average %97
    Range %91-105
    1:400Average %99
    Range %92-110
    1:800Average %97
    Range %86-98
  • 回收率：
    The recovery of human ITIH1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9389-98
    EDTA plasma (n=4)9790-104
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    10002.400 2.418 2.409 2.328
    5002.088 1.999 2.004 1.923
    2501.562 1.555 1.559 1.478
    1251.228 1.211 1.220 1.139
    62.50.689 0.665 0.677 0.596
    31.250.452 0.436 0.444 0.363
    15.60.270 0.254 0.262 0.181
    00.084 0.078 0.081 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.; Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
  • 基因功能參考文獻(xiàn)：
    1. Furthermore, thrombin treatment of the inflammatory matrix leads to dissolution of HC-HA cable structures and abolishes leukocyte adhesion. These data establish a novel mechanism whereby thrombin cleavage of HC1 regulates the adhesive properties of an inflammatory HA matrix. PMID: 27679489
    2. Data suggest that Mg2+ or Mn2+ (but not Ca2+) induce a conformational change in inter-alpha-inhibitor (ITIH1 and ITIH2) and a bikunin/chondroitin sulfate-dependent increase in thermodynamic stability; bikunin binds adjacent to the two heavy chains. PMID: 26728454
    3. The results of this study revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese population. PMID: 24389398
    4. Data indicate that TSG-6-mediated cross-linking of hyaluronan (HA) films is impaired in the presence of inter-alpha-inhibitor (IalphaI) and that this effect suppresses the TSG-6-mediated enhancement of HA binding to CD44-positive cells. PMID: 24005673
    5. Human inter-alpha-inhibitor is a substrate for factor XIIIa and tissue transglutaminase. PMID: 21939789
    6. Transfection into H460M Human large cell lung carcinoma line decreased tumor metastasis in nude mice PMID: 11807786
    7. PTX3 directly interacts with inter-alpha-trypsin inhibitor and has a role in hyaluronan organization and cumulus oophorus expansion PMID: 17675295
    8. The first systematic analysis on the differential expression of ITIH genes in human cancer, showing frequent downregulation that may be associated with initiation and/or progression of these malignancies. PMID: 18226209

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    ITIH family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6166

    OMIM: 147270

    KEGG: hsa:3697

    STRING: 9606.ENSP00000273283

    UniGene: Hs.420257