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  4. Human lymphotactin,Lptn/LTN ELISA Kit

Human lymphotactin,Lptn/LTN ELISA Kit

  • 中文名稱：
    人淋巴細(xì)胞趨化因子(Lptn/LTN/XCL1)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E08712h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人淋巴細(xì)胞趨化因子(Lptn/LTN/XCL1)酶聯(lián)免疫試劑盒（CSB-E08712h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿,組織勻漿樣本中的XCL1含量。XCL1 作為一個(gè)靶點(diǎn)，目前缺乏更多背景及研究機(jī)制的詳細(xì)信息。推測(cè)其在相關(guān)生理或病理過程有特定作用，但需更多研究來明確其在細(xì)胞信號(hào)傳導(dǎo)、疾病發(fā)生發(fā)展等方面具體機(jī)制及潛在治療價(jià)值。試劑盒檢測(cè)范圍為0.39 ng/ml- 25 ng/ml，該產(chǎn)品特別適用于科研領(lǐng)域探索XCL1在免疫性疾病模型、炎癥反應(yīng)通路研究及腫瘤免疫微環(huán)境調(diào)控中的表達(dá)特征，亦可用于體外藥物篩選實(shí)驗(yàn)中生物標(biāo)志物動(dòng)態(tài)監(jiān)測(cè)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ATAC ELISA Kit; C motif chemokine 1 ELISA Kit; Chemokine (C motif) ligand 1 ELISA Kit; Chemokine C Motif Ligand 1 ELISA Kit; Cytokine SCM-1 ELISA Kit; LPTN ELISA Kit; LTN ELISA Kit; Lymphotactin ELISA Kit; Lymphotaxin ELISA Kit; SCM 1 alpha ELISA Kit; SCM 1 ELISA Kit; SCM 1a ELISA Kit; SCM-1-alpha ELISA Kit; SCM1 ELISA Kit; SCM1A ELISA Kit; SCYC1 ELISA Kit; Single cysteine motif 1a ELISA Kit; Small inducible cytokine C1 ELISA Kit; Small Inducible Cytokine Subfamily C Member 1 ELISA Kit; Small inducible cytokine subfamily C, member 1 (lymphotactin) ELISA Kit; Small-inducible cytokine C1 ELISA Kit; X-C motif chemokine ligand 1 ELISA Kit; XC chemokine ligand 1 ELISA Kit; Xcl1 ELISA Kit; XCL1_HUMAN ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測(cè)范圍：
    0.39 ng/ml - 25 ng/ml
  • 靈敏度：
    0.0975 ng/ml
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
  • 基因功能參考文獻(xiàn)：
    1. higher serum XCL1 levels at diagnosis and their progressive decline throughout chemotherapy could be correlated with higher survival. PMID: 29027574
    2. This study defines a Glycosaminoglycan binding surface on XCL1 dimer that includes residues that are important for HIV-1 inhibition. PMID: 26836755
    3. Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin PMID: 26134347
    4. XCL1 acts via direct interaction with the external viral envelope glycoprotein, gp120, to block HIV-1 infection PMID: 26085164
    5. analysis of XCL1 and XCL2, members of the C-chemokine subfamily, in the immune system PMID: 25497737
    6. XCL1 displays antimicrobial activity against E. coli and S. aureus. PMID: 12949249
    7. XCL1-mediated inhibition is associated with direct interaction of the chemokine with the HIV-1 envelope. PMID: 24385911
    8. In native annulus fibrosus tissue homeostasis and repair, CXCR3 is evident, whereas XCL1 could not be detected. PMID: 21270681
    9. The expression patterns of XCR1 and XCL1 were conserved in human and mice blood cells, including certain dendritic cell subsets. PMID: 20541533
    10. Data indicated increased expression of XCL1 in CD4+ and CD8+ T cells in Wegener's granulomatosis (WG), and suggest that XCL1 might be a key modulator of T cell recruitment in WG. PMID: 19797511
    11. NMR spectra of human lymphotactin (hLtn), obtained under various solution conditions, have revealed that the protein undergoes a major conformational rearrangement dependent on temperature and salt concentration. PMID: 11889129
    12. lymphotactin, as well as MCP-1, may contribute to leukocyte infiltration and disease progression in IgA nephropathy. PMID: 12053063
    13. Lptn might be a key modulator for T cell trafficking in the pathogenesis of rheumatoid arthritis PMID: 12847680
    14. In humans XCL1 expression is mainly a property of CD8+ T cells; the contribution to its synthesis by different T cell receptor alpha beta-expressing T cell subsets, namely CD4+ lymphocytes, is negligible. PMID: 14568926
    15. lymphotactin utilizes highly specific glycosaminoglycan-binding sites PMID: 14707146
    16. XCL1 activation is positively correlated with HIV-1 Tat expression in human U87.MG astrocytes in vitro. PMID: 14734774
    17. description of a lymphotactin-producing monoclonal T-cell lymphoproliferative disorder with extreme lymphocytopenia and progressive leukoencephalopathy [case report] PMID: 16923584
    18. The monocyte-derived dendritic cells can express Lptn mRNA in a maturation-dependent manner. PMID: 17077010
    19. Elevated serum lymphotactin levels correlate with relatively milder manifestations in diffuse cutaneous systemic sclerosis (dSSc), especially lower severity of lung involvement, suggesting that lymphotactin may play a role in the development of dSSc. PMID: 18322986
    20. functional repertoire and regulation of a single naturally occurring amino acid sequence can be expanded by access to a set of highly dissimilar native-state structures PMID: 18364395
    21. XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma PMID: 18832695
    22. ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein PMID: 18838386

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine gamma family
  • 組織特異性：
    Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10645

    OMIM: 600250

    KEGG: hsa:6375

    STRING: 9606.ENSP00000356792

    UniGene: Hs.458346