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  4. Human melanin-concentrating hormone (PMCH) ELISA kit

Human melanin-concentrating hormone (PMCH) ELISA kit

  • 中文名稱：
    人黑色素濃縮激素(PMCH)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL018230HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人黑色素濃縮激素(PMCH)酶聯(lián)免疫試劑盒（CSB-EL018230HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的PMCH含量。PMCH即前黑素聚集激素，它是一種神經(jīng)肽。在其與能量代謝、睡眠覺醒等生理過程相關(guān)。研究機制上，主要是通過與特定受體結(jié)合，激活細(xì)胞內(nèi)信號通路來發(fā)揮作用，目前在肥胖、睡眠障礙等病癥的治療研究中受關(guān)注。試劑盒檢測范圍為15.6 pg/mL-1000 pg/mL，適用于探索PMCH在能量代謝調(diào)控、神經(jīng)內(nèi)分泌系統(tǒng)中的作用機制，或用于評估疾病模型、藥物干預(yù)實驗中的PMCH動態(tài)變化。該產(chǎn)品嚴(yán)格適配科研場景，為代謝性疾病、神經(jīng)科學(xué)等領(lǐng)域的基礎(chǔ)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    PMCH ELISA Kit; MCHPro-MCH [Cleaved into: Neuropeptide-glycine-glutamic acid ELISA Kit; NGE ELISA Kit; Neuropeptide G-E); Neuropeptide-glutamic acid-isoleucine ELISA Kit; NEI ELISA Kit; Neuropeptide E-I); Melanin-concentrating hormone ELISA Kit; MCH)] ELISA Kit
  • 縮寫：
    PMCH
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human PMCH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 95
    Range % 90-100
    1:2 Average % 87
    Range % 83-91
    1:4 Average % 92
    Range % 88-96
    1:8 Average % 90
    Range % 85-94
  • 回收率：
    The recovery of human PMCH spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 100 95-104
    EDTA plasma (n=4) 84 80-88
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    1000 2.682 2.533 2.608 2.400
    500 2.040 1.946 1.993 1.785
    250 1.419 1.357 1.388 1.180
    125 0.927 0.975 0.951 0.743
    62.5 0.654 0.689 0.672 0.464
    31.2 0.408 0.392 0.400 0.192
    15.6 0.335 0.324 0.330 0.122
    0 0.204 0.211 0.208 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

相關(guān)問答

■ 常見問題解答
Q:

你有EDTA血液中人血漿的參考范圍嗎?抗體的靶標(biāo)是什么？

A:
一般情況下，我們檢測的是正常的血清和血漿樣本，沒有明顯的病理變化，具體的樣本檢測請咨詢我們。

靶點詳情

  • 功能：
    MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. May also have a role in spermatocyte differentiation.
  • 基因功能參考文獻(xiàn)：
    1. MCH is an anabolic neuropeptide with multiple and diverse physiological functions including a key role in energy homoeostasis; evidence suggests that, in the reproductive context, MCH is a modulator rather than a primary regulator. PMID: 23884861
    2. Cerebrospinal fluid (CSF) levels were measured in 33 patients with Alzheimer's disease (AD) and 33 healthy subjects, to investigate the role of MCH and HCRT-1 in AD. PMID: 23667582
    3. the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala, are reported. PMID: 23462990
    4. Melanin-concentrating hormone (MCH) neurons of human hypothalamus, as well as the MCH neurons of mouse hypothalamus, contain IL-6Ralpha. PMID: 22295972
    5. PMCH mRNA expression level was increased 1.85 times (P < 0.01) in vitiligo uninvolved skin and 5.36 times (P < 0.01) in involved skin compared to healthy control skin. PMID: 20888736
    6. Melanin-concentrating hormone is expressed and functional in human skin PMID: 12176038
    7. RT-PCR analysis revealed a low expression of prepro-MCH and MCH receptor 1 (MCHR1) but not of MCHR2 transcript in tissular and peripheral blood immune cells PMID: 12220661
    8. Review. Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, which centrally regulates food intake and stress. MCH-R1 antagonists can probe additional functions of the peptide, both in the brain and in the peripheral nervous system. PMID: 12885269
    9. Serum levels could serve as useful peripheral markers of changes in energy homeostasis. PMID: 15546902
    10. hMCH increased water intake independent of food intake. It significantly increased both sucrose solution and food intake. PMID: 15870910
    11. Single nucleotide polymorphisms in pro-melanin-concentrating hormone may be associated with obesity and a greater body mass index in olanzapine-treated schizophrenic patients PMID: 17541984
    12. expression of PMCH by activated Th2 cells in vivo may directly link allergic inflammation to energy homeostasis and may contribute to the association between asthma and obesity PMID: 17640905
    13. The total number of hypocretin-1 neurons was significantly reduced by 30% in HD brains (P = 0.015), while the total number of MCH neurons was not significantly altered (P = 0.100). PMID: 18498421
    14. MCH has a role in inflammatory processes in the intestine PMID: 18650383

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Melanin-concentrating hormone family
  • 組織特異性：
    Predominantly expressed in lateral hypothalamus, also detected in pallidum, neocortex and cerebellum. Also found in thymus, brown adipose tissue, duodenum and testis (spermatogonia, early spermatocytes and Sertoli cells). No expression in peripheral blood
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9109

    OMIM: 176795

    KEGG: hsa:5367

    STRING: 9606.ENSP00000332225

    UniGene: Hs.707990