Human myeloperoxidase,MPO ELISA Kit
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中文名稱:人髓過氧化物酶(MPO)酶聯(lián)免疫試劑盒
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貨號:CSB-E08721h
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規(guī)格:96T/48T
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價格:¥3600/¥2500
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:人髓過氧化物酶(MPO)酶聯(lián)免疫試劑盒(CSB-E08721h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的MPO含量。MPO是髓過氧化物酶,是中性粒細(xì)胞發(fā)揮殺菌功能的關(guān)鍵酶。它參與炎癥反應(yīng)、氧化應(yīng)激等生理病理過程。研究其機(jī)制主要聚焦在其促炎效應(yīng)、氧化損傷作用等,明確其在疾病發(fā)生發(fā)展的作用,有望為相關(guān)疾病治療提供新靶點和策略。試劑盒檢測范圍為0.156 ng/mL-10 ng/mL,靈敏度為0.039 ng/mL。廣泛應(yīng)用于基礎(chǔ)醫(yī)學(xué)研究中MPO相關(guān)分子機(jī)制探索,包括炎癥性疾病模型建立、藥物干預(yù)效果評估、免疫細(xì)胞功能分析等科研場景,為揭示MPO在病理生理過程中的作用提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名:84 kDa myeloperoxidase ELISA Kit; 89 kDa myeloperoxidase ELISA Kit; EC 1.11.1.7 ELISA Kit; EC1.11.2.2 ELISA Kit; fj80f04 ELISA Kit; MPO ELISA Kit; mpx ELISA Kit; myeloid-specific peroxidase ELISA Kit; Myeloperoxidase ELISA Kit; Myeloperoxidase heavy chain ELISA Kit; Myeloperoxidase light chain ELISA Kit; PERM_HUMAN ELISA Kit; wu:fj80f04 ELISA Kit
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縮寫:
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates
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檢測范圍:0.156 ng/mL-10 ng/mL
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靈敏度:0.039 ng/mL
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反應(yīng)時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領(lǐng)域:Immunology
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測定原理:quantitative
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測定方法:Sandwich
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數(shù)據(jù)處理:
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貨期:3-5 working days
引用文獻(xiàn)
- Protein-enriched intermittent meal replacement combined with moderate-intensity training for weight loss and body composition in overweight women Q Liu, Y Guo, B Peng, D Fan, J Wu, J Wang, R Wang,Scientific Reports,2025
- Increased Adherence to the Mediterranean Diet after Lifestyle Intervention Improves Oxidative and Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease M Monserrat-Mesquida,Antioxidants,2023
- Marcadores de inflamación y estrés oxidativo en la prevención y reversión de la obesidad y sus comorbilidades asociadas M Monserrat Mesquida,/,2023
- Severity assessment of central nervous system infections by determining the level of myeloperoxidase protein in neutrophil extracellular traps (NETs) in cerebrospinal fluid: a retrospective case-control study MS Hejazi,/,2024
- Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps M Jiang,BMC immunology,2023
- Neuroprotective effects of niacin on ischemia/reperfusion injury of the rabbit spinal cord ? Ermutlu,World neurosurgery,2023
- Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty Liver Disease MM Quetglas-Llabrés,Antioxidants,2023
- A Greater Improvement of Intrahepatic Fat Contents after 6 Months of Lifestyle Intervention Is Related to a Better Oxidative Stress and Inflammatory Status in Non-Alcoholic Fatty Liver Disease M Monserrat-Mesquida,Antioxidants,2022
- Oxidative Stress and Pro-Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease M Monserrat-Mesquida,Antioxidants,2020
- The Effect of Aerobic Training with Vitamin C Supplementation on Myeloperoxidase, Asymmetric Dimethyl Arginine and Blood Pressure in Middle-Age … A Alishahi,JOURNAL OF CLINICAL RESEARCH IN PARAMEDICAL SCIENCES,2020
- Preparation of Monoclonal Antibodies and a Simple Myeloperoxidase-Immunosorbent Assay for Detecting Human Myeloperoxidase Bian Zhi-Ping.et al,Monoclonal Antibodies in Immunodiagnosis and Immunotherapy,2016
- MMPs and myeloperoxidase in GCF provide site-specific diagnostic value for chronic periodontitis Leppilahti J et al,J Clin Periodontol,2013
相關(guān)產(chǎn)品
靶點詳情
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功能:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
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基因功能參考文獻(xiàn):
- findings indicate that cyanide is a substrate for MPO and suggest an additional pathway for in vivo cyanate formation and protein carbamylation that involves MPO either directly or via its reaction products hypochlorous acid or chloramines. They also suggest that chronic cyanide exposure could promote the accumulation of carbamylated proteins in atherosclerotic plaques. PMID: 29496995
- These results indicate significant increases of MPO-immunoreactive cells in brain regions affected by neurodegeneration in Parkinson's disease and Alzheimer's Disease. PMID: 28466093
- Evidence has been presented for FN modification by inflammatory oxidants, and particularly myeloperoxidase (MPO)-derived species including hypochlorous acid (HOCl). Studies using primary human coronary artery smooth muscle cells show that exposure to HOCl-modified FN, results in decreased adherence, increased proliferation and altered expression of genes involved in extracellular matrix synthesis and remodelling. PMID: 30237127
- MPO -463G > A was not associated with chronic kidney disease (CKD) susceptibility in recessive model and homozygote comparison. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed. [meta-analysis] PMID: 30278820
- data suggest that the decomposition of dimeric MPO into monomers can serve as a regulatory mechanism that controls MPO-dependent activation of neutrophils and reduces the proinflammatory effects of MPO. PMID: 29585927
- High MPO expression is associated with cardiometabolic risk factors, and distal sensorimotor polyneuropathy. PMID: 29577557
- Our results suggest that the presence of MPO polymorphism, -463 G>A in patients might offer them protection against cervical cancer. PMID: 29937309
- Results found that myeloperoxidase genes is up-regulated in both overweight and obese subjects and associated with BMI and markers of cardiovascular disease. PMID: 30056589
- Myeloperoxidase -463 G/A polymorphism is associated with lung cancer risk. PMID: 29970677
- MPO gene SNP (rs2107545) was associated with type 2 diabetes mellitus susceptibility in Chinese Han population. PMID: 29383971
- Myeloperoxidase serum level in stable coronary disease is predicitve of the risk of acute coronary syndrome. PMID: 29618370
- According to results, MPO G+ genotype and AG genotype were significantly increased in endometrial carcinoma patients as compared to controls. PMID: 29631687
- The level of myeloperoxidase in plasma of patients with acute myocardial infarction depends on the functional state of neutrophils. PMID: 29975476
- Glycosylation critically determines the enzymatic activity of MPO. Deglycosylation decreased oxidation activity of MPO and its binding with ceruloplasmin and decreased the microbicidal effect of MPO. Deglycosylated MPO presented less antigenicity to MPO-ANCA. PMID: 27643667
- Maternal myeloperoxidase activity was similar in both neural tube defect-affected pregnancies and healthy controls. PMID: 28397206
- Data show that pro-myeloperoxidase (pro-MPO) was more frequently detected in plasma from patients with myocardial infarction compared to plasma from control donors. PMID: 29590135
- Increased MPO indexed to HDL particle concentration (MPO/HDLp) at baseline is associated with increased risk of incident cardiovascular disease events. PMID: 28645072
- Evidence was sufficient to show the association between MPO-463G > A polymorphism and cancer risk.[meta-analysis] PMID: 28764808
- Aberrant glycosylated MPO exposed neo-epitopes and was recognized by half of the patients with anti-GBM disease. Their antibodies possessed pathogenic characteristics and may be associated with kidney injury. PMID: 28187981
- Data suggest that increased serum anti-MPO antibody levels are associated with retinal photoreceptor ellipsoid zone disruption and decreased visual acuity in diabetic retinopathy in patients with type 2 diabetes. This study was conducted in India. PMID: 28279572
- MPO concentrations showed positive correlations with sCD40L, ADMA, and sICAM-1 levels in overweight patients with newly diagnosed untreated hyperlipidaemia. PMID: 28602123
- This study revealed that epistatic interaction among the ALOX5, ALOX5AP and MPO genes played a significant role in vulnerability to ischemic stroke. PMID: 29041000
- Osteopontin, neopterin, and myeloperoxidase were independently associated with the risk of recurrent stroke and improved risk classification when added to a clinical risk algorithm PMID: 29114094
- peroxidase enzymes, like MPO and EPO, may play a fundamental role in inhibiting RANKL-induced osteoclast differentiation at inflammatory sites of bone fracture and injury. PMID: 27836774
- MPO complexed with HLA class II molecules is involved in the pathogenesis of MPA as a target for MPO-ANCA. PMID: 28575531
- PIC1 inhibits the peroxidase activity of myeloperoxidase in Cystic fibrosis sputum likely via an antioxidant mechanism. PMID: 28135312
- In absence of CALR, immature MPO protein precursors are degraded in the proteasome. PMID: 27013444
- Meta-analysis suggested an association between the MPO 463G/A polymorphism and the risk of coronary artery disease, but there is no significant association between the MPO 129G/A gene polymorphism and coronary artery disease risk. PMID: 28682877
- Both MPO and EPO are causatively involved in breast cancer progression and identified as potential therapeutic targets whereby specific novel inhibitors may reduce tumor growth and limit the occurrence of metastasis. PMID: 28260049
- Although IgA anti-MPO antibodies are detectable in some patients with eosinophilic granulomatosis with polyangiitis and may be detectable more frequently during active disease, their presence seems unlikely to provide information beyond what is obtained from conventional IgG anti-MPO. PMID: 28281453
- Clinical manifestations varied ANCA-associated vasculitis categories, and neither MPO-ANCA nor PR3-ANCA significantly affected relapse of AAV. PMID: 28339364
- MPO levels were higher in those patients infected with H. pylori irrespective of the virulence factors than those uninfected patients. PMID: 27048452
- The present study determined that ARE, CLP, CAT, and MPO levels are different between the pediatric patients with sepsis and healthy controls. ARE level can be a potent biomarker for sepsis in critical patients in intensive care units. PMID: 28167245
- Studies of the mutants C158A, C319A, and C158A/C319A demonstrated significant differences from the wild-type protein, including diminished enzymatic activity and prevention of export to the Golgi due to prolonged association with the chaperone calnexin. These structural and functional findings provide novel insights into MPO biosynthesis and processing. PMID: 28348079
- Consistent with these in vitro data, in diabetic rat aortas, both MPO expresion and NADPH oxidase activity were increased while the endothelial function was simultaneously impaired. The results suggested that vascular-bound MPO could amplify high glucose-induced vascular injury in diabetes. MPO-NADPH oxidase-HOCl may represent an important pathogenic pathway in diabetic vascular diseases. PMID: 28131839
- Patients with active disease demonstrated hypomethylation of myeloperoxidase and proteinase 3 and increased expression of the autoantigens; in remission, DNA methylation generally increased PMID: 27821628
- Myeloperoxidase-oxidized high density lipoprotein impairs atherosclerotic plaque stability by inhibiting smooth muscle cell migration. PMID: 28069011
- The roles of myeloperoxidase in coronary artery disease [review] PMID: 27884085
- Study shows that MPO and PRTN3 in neutrophils of Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) patients with active disease have a distinct pattern of histone modifications, which implicates epigenetic mechanisms in regulating expression of autoantigen genes and suggests that the epigenome may be involved in AAV pathogenesis. PMID: 27752292
- Data suggest that the system of MPO/hydrogen peroxide/chloride ions exhibits activity able to oxidize dibromoacetonitrile, a by-product of water treatment/disinfection and potential carcinogen, to cyanide, a known poison. PMID: 25614581
- Compared with the commercial human MPO ELISA assay, the MPO-ISA can be used to detect the natural human MPO protein, but not recombinant MPO polypeptides. The generated mAbs and MPO-ISA test may be useful tools to assess risk for inflammation and cardiac events PMID: 26978734
- The MPO gene -463G/A polymorphism is associated with Coronary Artery Disease risk, especially within the Chinese population. PMID: 28328864
- Study demonstrated that the MPO -463G>A SNP may protect from cervical squamous cell carcinoma in women from Polish Caucasian populations. PMID: 27197583
- The collected data showed a correlation between the occurrence of superimposed thrombosis in respiratory infection patients, and the intensity of the inflammatory process, reflected by the increased MPO activity, and the dynamics of LpPLA2 and VEGF. PMID: 27928450
- results suggest that the acute inflammatory response induced by thermal injury involves activation of neutrophils and is accompanied by MPO release into the plasma. MPO-mediated modification of serum albumin induces its capacity to prime neutrophils and thus to enhance further inflammatory reaction. PMID: 27797335
- The difference in MPO between women with abnormal and normal menstrual cycles and the upregulation of MPO before ovulation suggest that neutrophils and MPO are closely related to ovulation. PMID: 28013526
- The results suggest that G allele of Myeloperoxidase -463G>A polymorphism is a potential genetic marker for Kawasaki disease risk in Taiwanese children. PMID: 26066543
- Genetic polymorphisms in eNOS, catalase and myeloperoxidase and their significance in a cohort of Turkish prostate cancer patients. PMID: 27706591
- ANCA affinity was associated with the in vivo formation of neutrophil extracellular traps, which might be involved in the pathophysiology of patients with MPO-ANCA-associated microscopic polyangiitis. PMID: 26833773
- Study demonstrated the possibility of biodegradation of fullerene molecule using the human neutrophil enzyme myeloperoxidase, which leads to the formation of non-aromatic compounds and to the loss of the fullerene molecule topology PMID: 28058679
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相關(guān)疾?。?/div>Myeloperoxidase deficiency (MPOD)亞細(xì)胞定位:Lysosome.蛋白家族:Peroxidase family, XPO subfamily數(shù)據(jù)庫鏈接:
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