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  4. Human neuregulin-2 (NRG2) ELISA kit

Human neuregulin-2 (NRG2) ELISA kit

  • 中文名稱：
    人神經(jīng)調(diào)節(jié)蛋白2(NRG2)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL016078HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人神經(jīng)調(diào)節(jié)蛋白2(NRG2)酶聯(lián)免疫試劑盒（CSB-EL016078HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的NRG2含量。NRG2即神經(jīng)調(diào)節(jié)蛋白2，它參與細(xì)胞的生長、分化和存活等過程。研究發(fā)現(xiàn)其通過與細(xì)胞膜上的ErbB受體家族結(jié)合并激活下游信號通路發(fā)揮作用，在神經(jīng)系統(tǒng)發(fā)育及癌癥、心血管疾病等病理過程中有潛在作用，是藥物研發(fā)潛在靶點。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，該產(chǎn)品適用于基礎(chǔ)科研領(lǐng)域，如神經(jīng)生物學(xué)研究、細(xì)胞信號通路探索或疾病模型（如神經(jīng)退行性疾病、精神類疾病）中NRG2動態(tài)變化的檢測，亦可用于藥物干預(yù)實驗或基因編輯技術(shù)對NRG2表達(dá)影響的評估，為相關(guān)分子機制研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Divergent of neuregulin 1 ELISA Kit; Divergent of neuregulin-1 ELISA Kit; Don 1 ELISA Kit; DON-1 ELISA Kit; Neural- and thymus-derived activator for ERBB kinases ELISA Kit; Neuregulin 2 ELISA Kit; Neuregulin-2 ELISA Kit; NRG-2 ELISA Kit; Nrg2 ELISA Kit; NRG2_HUMAN ELISA Kit; NTAK ELISA Kit; Pro NRG2 ELISA Kit; Pro-NRG2 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human NRG2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:5 Average % 101
    Range % 88-105
    1:10 Average % 100
    Range % 90-105
    1:20 Average % 97
    Range % 88-101
    1:40 Average % 99
    Range % 94-102
  • 回收率：
    The recovery of human NRG2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 94 87-97
    EDTA plasma (n=4) 101 95-107
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    2000 2.638 2.567 2.603 2.404
    1000 2.312 2.222 2.267 2.068
    500 1.722 1.787 1.755 1.556
    250 1.156 1.129 1.143 0.944
    125 0.702 0.684 0.693 0.494
    62.5 0.501 0.513 0.507 0.308
    31.25 0.326 0.338 0.332 0.133
    0 0.201 0.197 0.199 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
  • 基因功能參考文獻：
    1. reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. PMID: 27345716
    2. examination of the effect of isoforms on angiogenesis PMID: 14722120
    3. Nrg-2-induced Acetylcholine Receptor transcription requires an N-box motif and is regulated by alternative splicing. PMID: 15961242
    4. Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma. PMID: 17563728
    5. Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence. PMID: 17945187
    6. NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer. PMID: 17962208

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  • 亞細(xì)胞定位：
    [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-2]: Secreted.
  • 蛋白家族：
    Neuregulin family
  • 組織特異性：
    Restricted to the cerebellum in the adult.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7998

    OMIM: 603818

    KEGG: hsa:9542

    STRING: 9606.ENSP00000354910

    UniGene: Hs.408515