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  4. Human neuromedin U (NMU) ELISA kit

Human neuromedin U (NMU) ELISA kit

  • 中文名稱：
    人神經(jīng)調(diào)節(jié)肽U(NMU)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL015902HU
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人神經(jīng)調(diào)節(jié)肽U(NMU)酶聯(lián)免疫試劑盒（CSB-EL015902HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、腦脊液（CSF）、組織勻漿樣本中的NMU含量。NMU（神經(jīng)介素 U）是一種神經(jīng)肽。它在體內(nèi)多種生理過程中發(fā)揮作用，如能量代謝、心血管調(diào)節(jié)等。其研究機制主要圍繞與特定受體結(jié)合，激活下游信號通路，影響細胞的功能和機體的生理狀態(tài)，目前針對它在疾病治療等方面的研究也在不斷深入。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，穩(wěn)定的性能適用于探究NMU在神經(jīng)系統(tǒng)疾病模型、代謝相關(guān)機制或生理調(diào)控中的表達變化，例如通過分析不同病理條件下腦脊液或組織樣本的NMU水平，揭示其與能量穩(wěn)態(tài)、應激反應的關(guān)聯(lián)性。為體外實驗研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Neuromedin U 25 ELISA Kit; Neuromedin U ELISA Kit; Neuromedin-U-25 ELISA Kit; NmU 25 ELISA Kit; NMU ELISA Kit; NmU-25 ELISA Kit; NMU_HUMAN ELISA Kit
  • 縮寫：
    NMU
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cerebrospinal fluid (CSF), tissue homogenates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of Human NMU in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %84-98
    1:2Average %92
    Range %86-98
    1:4Average %94
    Range %84-98
    1:8Average %94
    Range %88-98
  • 回收率：
    The recovery of Human NMU spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9892-102
    EDTA plasma (n=4)8884-94
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    202.585 2.387 2.486 2.314
    102.058 1.896 1.977 1.805
    51.375 1.304 1.340 1.168
    2.50.852 0.879 0.866 0.694
    1.250.574 0.552 0.563 0.391
    0.6250.369 0.384 0.377 0.205
    0.3120.271 0.265 0.268 0.096
    00.172 0.171 0.172
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Ligand for receptors NMUR1 and NMUR2. Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36.; Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system.
  • 基因功能參考文獻：
    1. Results identified NMU as highly expressed in non-small cell lung cancer (NSCLC) tissues and cell lines. Furthermore, integrative bioinformatics analyses demonstrate that NMU may confer the alectinib resistance in NSCLC via multiple mechanisms. PMID: 30096454
    2. NMU might contribute to progression of NMUR2-positive breast cancer PMID: 28423716
    3. The anti-tumorigenic effect of HAND2-AS1 in endometrioid endometrial carcinoma was mediated by down-regulating neuromedin U expression. PMID: 29107108
    4. Results indicate a mechanism of action for neuromedin U (NmU) in HER2-overexpressing breast cancer that enhances resistance to HER2-targeted drugs through conferring cancer stem cell (CSC) characteristics and expansion of the CSC phenotype. PMID: 28340506
    5. This study shows an association between a NMU haplotype and anthropometric indices, mainly linked to fat mass, which appears to be age- and sex-specific in children. PMID: 28235053
    6. Overexpression of Nmu may be involved in the process of regional metastasis of HNSCC, and may serve as a novel and valuable biomarker for predicting regional metastasis in patients with HNSCC. PMID: 27279246
    7. polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. PMID: 25871004
    8. our results defined NmU as a candidate drug response biomarker for HER2-overexpressing cancers and as a candidate therapeutic target to limit metastatic progression and improve the efficacy of HER-targeted drugs. PMID: 24876102
    9. a role for NMU gene through interaction with ADRB2 gene in bone strength regulation PMID: 23936460
    10. Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells. PMID: 21791076
    11. [review] Taken together with its vascular actions, NMU may be a functional link between energy balance and the cardiovascular system and may provide a future target for therapies directed against the disorders that comprise metabolic syndrome. PMID: 19519756
    12. These results suggest that NMU plays a role in feeding behavior and catabolic functions via corticotropin-releasing hormone. PMID: 14623274
    13. NmU expression is related to Myb and that the NmU/NMU1R axis constitutes a previously unknown growth-promoting autocrine loop in myeloid leukemia cells PMID: 15187020
    14. irreversible binding of NmU to its receptors PMID: 15331768
    15. Overexpression of neuromedin U is associated with bladder tumor formation, lung metastasis and cancer cachexia PMID: 16878152
    16. Amino acid variants in NMU associate with overweight and obesity, suggesting that NMU is involved in energy regulation in humans. PMID: 16984985
    17. NMU & its cancer-specific receptors, as well as its target genes, are frequently overexpressed in clinical samples of lung cancer and in cell lines, and that those gene products play indispensable roles in the growth and progression of lung cancer cells. PMID: 17018595
    18. NmU may be involved in the HGF-c-Met paracrine loop regulating cell migration, invasiveness and dissemination of pancreatic ductal adenocarcinoma. PMID: 19118941

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    NmU family
  • 組織特異性：
    Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7859

    OMIM: 605103

    KEGG: hsa:10874

    STRING: 9606.ENSP00000264218

    UniGene: Hs.418367