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  4. Human orphanin FQ/nociceptin,OFQ/N ELISA Kit

Human orphanin FQ/nociceptin,OFQ/N ELISA Kit

  • 中文名稱：
    人孤腓肽(OFQ/N)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09741h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人孤腓肽(OFQ/N)酶聯(lián)免疫試劑盒（CSB-E09741h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織培養(yǎng)上清液樣本中的PNOC含量。PNOC是一種靶點(diǎn)。它可能參與體內(nèi)多種生理過(guò)程，其相關(guān)研究機(jī)制或是從神經(jīng)調(diào)節(jié)、內(nèi)分泌等方面入手。通過(guò)對(duì)PNOC進(jìn)行深入研究，有望在神經(jīng)、內(nèi)分泌等相關(guān)疾病的治療上挖掘新的藥物靶點(diǎn)，為開(kāi)發(fā)新療法提供理論依據(jù)。試劑盒檢測(cè)范圍為4.69 pg/mL-300 pg/mL，適用于神經(jīng)生物學(xué)、藥理學(xué)等領(lǐng)域的基礎(chǔ)研究，例如探索疼痛機(jī)制、精神疾病模型中的肽類表達(dá)變化，或評(píng)估細(xì)胞實(shí)驗(yàn)中OFQ/N的分泌動(dòng)態(tài)。通過(guò)可靠的定量結(jié)果，為科研人員解析OFQ/N在生理及病理過(guò)程中的調(diào)控作用提供有力工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書。
  • 別名：
    N/OFQ ELISA Kit; N23K ELISA Kit; N23K/N27K ELISA Kit; Nociceptin, included ELISA Kit; nocistatin ELISA Kit; Npnc1 ELISA Kit; OFQ ELISA Kit; OFQ/N ELISA Kit; Orphanin FQ ELISA Kit; Orphanin FQ2 ELISA Kit; Pnoc ELISA Kit; PNOC_HUMAN ELISA Kit; ppN/OFQ ELISA Kit; PPNOC ELISA Kit; pre-pro-N/OFQ ELISA Kit; prepronociceptin ELISA Kit; pronociceptin ELISA Kit; Propronociceptin ELISA Kit
  • 縮寫：
    OFQ/N
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, cell culture supernates
  • 檢測(cè)范圍：
    4.69 pg/mL-300 pg/mL
  • 靈敏度：
    1.17 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Neuroscience
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human OFQ/N in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)  
    1:1 Average % 91  
    Range % 80-105  
    1:2 Average % 96  
    Range % 85-114  
    1:4 Average % 93  
    Range % 92-114  
    1:8 Average % 95  
    Range % 80-110  
  • 回收率：
    The recovery of human OFQ/N spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 93 80-110  
    EDTA plasma (n=4) 95 90-102  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected  
    300 2.614 2.621 2.618 2.475  
    150 1.882 1.887 1.885 1.742  
    75 1.325 1.330 1.328 1.185  
    37.5 0.771 0.774 0.773 0.630  
    18.75 0.439 0.441 0.440 0.297  
    9.38 0.268 0.284 0.276 0.133  
    4.69 0.236 0.252 0.244 0.101  
    0 0.138 0.148 0.143 　  
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.; Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia.; Has potent analgesic activity.
  • 基因功能參考文獻(xiàn)：
    1. found differences in Neonatal Abstinence Syndrome outcomes depending on PNOC and COMT SNP genotype. PMID: 27983768
    2. The presence of the PNOC rs732636 A allele was associated with the worse Neonatal abstinence syndrome outcomes in infants. PMID: 26791055
    3. Data suggest that nociceptin plays a crucial role in progress of meiosis during spermatogenesis. [REVIEW] PMID: 25677772
    4. Data suggest that both nociceptin and nocistatin inhibit myometrial contractions and may play roles in perception of pain during delivery. [REVIEW] PMID: 25677774
    5. REVIEW: intracellular localization and physiological role of nociceptin and nocistatin PMID: 23454174
    6. Strong expression of PNOC was seen in neoplastic neurons of 7/7 brainstem gangliogliomas, but was significantly weaker in non-brainstem GGs. PMID: 22706982
    7. The presence of Orphanin, Oxytocin, ANP, eNOS and iNOS proteins was identified in the human umbilical cord.[Orphanin] PMID: 21744319
    8. A high expression of nociceptin in adenomyosis may be one of the casual factors of dysmenorrhea. The severity of dysmenorrhea is positively correlated with the expression of nociceptin in eutopic endometrial tissue. PMID: 21600132
    9. chronic ischemic conditions of atherosclerotic origin are associated with significantly lower plasma nociceptin levels PMID: 21310194
    10. PNOC expression level was 2.99 times higher in vitiligo involved skin when compared to healthy control skin. PMID: 20888736
    11. Results showed that vigorous and prolonged hyperventilation changes plasma nociceptin/orphanin FQ levels due to the direct effects of hypocapnic alkalosis or to different sympatho-adrenergic system responses. PMID: 20100531
    12. Peripheral blood levels are elevated in Wilson disease PMID: 12812047
    13. results show that nociceptin/NociR is present and functional in human neutrophils, and the results identify a novel dialogue pathway between neural and immune tissues PMID: 12950177
    14. The presence of two different forms of mature nocistatin (NST-17 and NST-30) and a possible N-terminal methionine cleaved NST-29 have been confirmed by both radioimmunoassay and mass spectrometry. PMID: 16043263
    15. Two SNPs in PNOC showed marginal association with alcoholism and one with illicit drug dependence. PMID: 17910740
    16. Peripheral blood mononuclear cells transcribe pre-pro-nociception/orphaninFQ. PMID: 18292431
    17. Unstable angina is associated with a significant increase in circulating nociceptin/orphanin FQ levels unrelated to intervening transient myocardial ischemia or hemodynamic changes. PMID: 19560501

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Opioid neuropeptide precursor family
  • 組織特異性：
    Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9163

    OMIM: 601459

    KEGG: hsa:5368

    STRING: 9606.ENSP00000301908

    UniGene: Hs.88218