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Human osteocrin,Ostn ELISA kit

  • 中文名稱：
    人骨織素(Ostn)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E12021h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人骨織素(Ostn)酶聯(lián)免疫試劑盒（CSB-E12021h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的OSTN含量。人骨織素（Ostn）是一種由骨骼細(xì)胞分泌的糖蛋白，參與骨代謝調(diào)控和能量穩(wěn)態(tài)維持。其研究機(jī)制涉及調(diào)節(jié)細(xì)胞粘附、遷移、增殖和分化等生物學(xué)功能，通過整合素受體激活細(xì)胞內(nèi)信號(hào)通路，影響細(xì)胞生長(zhǎng)和行為。試劑盒檢測(cè)范圍為0.312 ng/mL-20 ng/mL，適用于基礎(chǔ)科研場(chǎng)景，如探索骨骼疾病機(jī)制、評(píng)估骨代謝相關(guān)生物標(biāo)志物或研究能量代謝調(diào)控網(wǎng)絡(luò)。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    OSTN ELISA Kit; Osteocrin ELISA Kit; Musclin) [Cleaved into: Processed Osteocrin] ELISA Kit
  • 縮寫：
    OSTN
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Stem Cells
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human Ostn in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %87
    Range %82-92
    1:2Average %99
    Range %94-103
    1:4Average %96
    Range %92-99
    1:8Average %95
    Range %88-98
  • 回收率：
    The recovery of human Ostn spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9489-97
    EDTA plasma (n=4)9791-99
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    202.552 2.699 2.626 2.510
    102.254 2.373 2.314 2.198
    51.804 1.928 1.866 1.750
    2.50.889 0.926 0.908 0.792
    1.250.517 0.498 0.508 0.392
    0.6250.320 0.304 0.312 0.196
    0.3120.216 0.202 0.209 0.093
    00.118 0.114 0.116 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inhibits dendritic branching in neurons of the developing cortex. Probably acts by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production.
  • 基因功能參考文獻(xiàn)：
    1. The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus. PMID: 28185530
    2. findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates PMID: 27830782
    3. osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator PMID: 14523025
    4. Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells. PMID: 17950246
    5. Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide. PMID: 17951249
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 19453261

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Osteocrin family
  • 組織特異性：
    Enriched in neocortical regions of the developing cerebral cortex. Not expressed in other compartments of the neocortical wall or in brain regions such as the hippocampus, striatum, mediodorsal nucleus of the thalamus and cerebellum. Also expressed in bon
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29961

    OMIM: 610280

    KEGG: hsa:344901

    STRING: 9606.ENSP00000342356

    UniGene: Hs.526794