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  4. Human placenta lactogen,HPL ELISA Kit

Human placenta lactogen,HPL ELISA Kit

  • 中文名稱：
    人胎盤催乳素(HPL)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E09665h
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人胎盤催乳素(HPL)酶聯(lián)免疫試劑盒（CSB-E09665h）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿樣本中的CSH1含量。試劑盒檢測范圍為80 ng/mL-4000 ng/mL，該產(chǎn)品適用于科研領(lǐng)域?qū)θ焉锲谔ケP功能、胎兒生長調(diào)控機制的研究，也可用于妊娠相關(guān)疾病模型的激素水平分析，例如妊娠糖尿病、子癇前期等病理狀態(tài)的分子機制探索。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CSH1Chorionic somatomammotropin hormone 1 ELISA kit; Choriomammotropin ELISA kit; Lactogen ELISA kit; Placental lactogen ELISA kit; PL ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    80 ng/mL-4000 ng/mL
  • 靈敏度：
    100 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<15%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human HPL in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %91
    Range %85-100
    1:2Average %96
    Range %90-105
    1:4Average %97
    Range %92-105
    1:8Average %95
    Range %89-100
  • 回收率：
    The recovery of human HPL spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9489-98
    EDTA plasma (n=4)9790-103
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    40002.028 2.067 2.048 2.002
    16001.434 1.457 1.446 1.400
    6000.767 0.785 0.776 0.730
    2000.395 0.413 0.404 0.358
    800.192 0.196 0.194 0.148
    00.045 0.047 0.046 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
  • 基因功能參考文獻：
    1. FGF-2b and hPL-A are promising candidates for regenerative therapy in Diabetes Mellitus by inducing de-differentiation of stem cells modulating pivotal endocrine genes. PMID: 29068419
    2. Placental lactogen is expressed but is not translated into protein in breast cancer. PMID: 24475273
    3. These results indicate that placental lactogen induces CYP2E1 expression via PI3-kinase pathway in human hepatocytes. PMID: 24408518
    4. Expression of placental lactogen mRNA is increased in plasma of women with placenta previa and invasive placenta. PMID: 23744883
    5. altered expression of placenta lactogen appears not to be causal for betamethasone-induced fetal growth restriction in the human PMID: 23465880
    6. results are consistent with a pleiotropic effect of placental hGH/CSH genes at the maternal-fetal interface relating to the regulation of fetal growth and the risk of affected maternal metabolism. PMID: 22387044
    7. Data conclude that members of the C/EBP and Ets families can differentially modulate CS-Benh and CS-Aenh activity. PMID: 21737519
    8. hPL-A is involved in the regulation of pancreatic beta cells activity. PMID: 21765243
    9. Results strongly support a conformationally mediated obligate-ordered prolactin receptor binding for each of the three lactogenic hormones: prolactin, growth hormone, and placental lactogen. PMID: 20427283
    10. The human growth hormone/chorionic somatomammotropin at chromosome 17 is implicated in regulation of postnatal and intrauterine growth. PMID: 20233782
    11. Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q. PMID: 11897833
    12. a role for CSH1 haploinsufficiency in the etiology of growth retardation PMID: 14642004
    13. These data implicate ETS-domain family members in the regulation of the CS locus in placenta and pituitary cells. PMID: 14673137
    14. We showed that intra-arterial infusion of human placental lactogen primarily decreased coronary, renal & iliac blood flow. Mechanism of this response was shown to be due to inhibition of vasodilatory beta2-adrenergic receptor-mediated effect. PMID: 16410683
    15. crystal structure of the free state of human PL has been determined to 2.0 A resolution showing the molecule possesses an overall structure similar to other long chain four-helix bundle cytokines PMID: 16546209
    16. The present findings indicate that the concentration of human placental lactogen (hPL) and human chorionic gonadotropin (beta hCG) mRNA is significantly higher in the cellular component of maternal blood samples than in the plasma component. PMID: 16950818
    17. A CSH1 deletion carrier with nearly complete hypomethylation at the ICR1 locus had the characteristic clinical signs of Silver Russel syndrome, ruling out a causal relationship. PMID: 17400796
    18. Placental lactogen is a novel ligand of stabilin-1. PMID: 18292525
    19. Three single nucleotide polymorphisms in CGB5 and CSH1 genes were genotyped for 844 offspring of the cases and controls. Maternal breast cancer risk did not significantly differ by the offspring's carrier status of the three SNPs. PMID: 19047151
    20. maternal smoking associated with a reduction in cord blood hPL PMID: 19290844

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Somatotropin/prolactin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2440

    OMIM: 150200

    KEGG: hsa:1442

    STRING: 9606.ENSP00000316416

    UniGene: Hs.654390