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  4. Human ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) (RNASE2) ELISA kit

Human ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) (RNASE2) ELISA kit

  • 中文名稱：
    人核糖核酸酶，核糖核酸酶A家族，（肝臟，嗜酸性粒細(xì)胞源性神經(jīng)毒素）(RNASE2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E17923h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人核糖核酸酶，核糖核酸酶A家族，（肝臟，嗜酸性粒細(xì)胞源性神經(jīng)毒素）(RNASE2)酶聯(lián)免疫試劑盒（CSB-E17923h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的RNASE2含量。RNASE2 即核糖核酸酶 2，是一種分泌型核糖核酸酶。它在免疫調(diào)節(jié)、炎癥反應(yīng)等方面有重要作用。研究顯示其能與病原體 RNA 相互作用，參與機(jī)體天然免疫防御；還可調(diào)節(jié)免疫細(xì)胞活性和細(xì)胞因子分泌，在相關(guān)疾病治療上有潛在研究?jī)r(jià)值。試劑盒檢測(cè)范圍為78 pg/mL-5000 pg/mL，適用于基礎(chǔ)醫(yī)學(xué)研究中RNASE2蛋白表達(dá)的動(dòng)態(tài)監(jiān)測(cè)，如探究嗜酸性粒細(xì)胞相關(guān)疾?。ㄈ缦裾睿┑姆肿訖C(jī)制、評(píng)估肝臟免疫微環(huán)境變化、解析感染性疾病中宿主防御反應(yīng)等科研場(chǎng)景，為炎癥調(diào)控網(wǎng)絡(luò)及免疫病理研究提供靈敏穩(wěn)定的檢測(cè)工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    RNASE2 ELISA Kit; EDN ELISA Kit; RNS2 ELISA Kit; Non-secretory ribonuclease ELISA Kit; EC 4.6.1.18 ELISA Kit; Eosinophil-derived neurotoxin ELISA Kit; RNase UpI-2 ELISA Kit; Ribonuclease 2 ELISA Kit; RNase 2 ELISA Kit; Ribonuclease US ELISA Kit
  • 縮寫：
    RNASE2
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    78 pg/mL-5000 pg/mL
  • 靈敏度：
    19.5 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human RNASE2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %92
    Range %86-95
    1:2Average %104
    Range %98-107
    1:4Average %93
    Range %87-97
    1:8Average %98
    Range %91-101
  • 回收率：
    The recovery of human RNASE2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9489-97
    EDTA plasma (n=4)10091-103
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    50002.054 2.000 2.027 1.926
    25001.589 1.576 1.583 1.482
    12500.928 0.913 0.921 0.820
    6250.440 0.454 0.447 0.346
    3120.300 0.308 0.304 0.203
    1560.222 0.230 0.226 0.125
    780.159 0.162 0.161 0.060
    00.102 0.100 0.101
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
  • 基因功能參考文獻(xiàn)：
    1. In healthy children, 95th Percentile values ranged from 1519 mg/kg at 0 months to 54.4 mg/kg at 144 months for fecal calprotectin (fCP) and from 9.9 mg/kg at 0 months to 0.2 mg/kg at 144 months for fecal eosinophil-derived neurotoxin (fEDN). There was a significant association between age and fCP concentrations and age and fEDN concentrations and a significant association between fEDN and fCP. PMID: 28169973
    2. EDN serum level could be considered a candidate molecule as a clinical biomarker for evaluating atopic dermatitis activity and a predictor of relapse PMID: 28866306
    3. Serum EDN level may be a useful marker for monitoring persistent airflow limitation in adult patients with asthma who had positive results for house-dust-specific IgE antibodies. PMID: 26534742
    4. increased in feces after the ingestion of enterocolitis-causative foods PMID: 24890227
    5. RNASE2 gene expression was differentially expressed in rheumatoid arthritis patients considering a sequence polymorphism. PMID: 25221852
    6. The antimicrobial protein, RNase 2 exhibits antiviral against respiratory syncytial virus. PMID: 9826755
    7. findings show substantial amounts of EPX/EDN localise in an extra-granular, low equilibrium density compartment of eosinophils PMID: 23053729
    8. A higher level of serum EDN was found specifically in patients with ALS, indicating that EDN may participate in the pathophysiology of Amyotrophic lateral sclerosis. PMID: 23533305
    9. Eosinophil protein X in urine from asymptomatic neonates is a biomarker significantly associated with later development of allergic sensitization, nasal eosinophilia, and eczema during the first 6 years of life PMID: 21680952
    10. atomic resolution structure PMID: 11876642
    11. crystal structure of a post-translationally modified form of eosinophil-derived neurotoxin (EDN) with four extra residues on its N terminus ((-4)EDN) has been solved and refined at atomic resolution (1 A) PMID: 11916383
    12. EDN and ECP are paralogs in human and Old World monkeys. PMID: 11959927
    13. evidence for glycosylphosphatidylinositol (GPI)-anchored neurotoxin on granulocytes PMID: 12606041
    14. data suggest that peripheral blood eosinophils from subjects with untreated asthma have increased inflammatory capacity, as reflected by greater intracellular concentrations of EDN PMID: 15356558
    15. Results reveal the dendritic cell-activating activity of eosinophil-derived neurotoxin and suggest that it is a likely participant of inflammatory and immune responses--an endogenous multifunctional immune alarmin. PMID: 15528350
    16. Results describe the crystal structure of placental ribonuclease inhibitor in complex with eosinophil-derived neurotoxin, and a mutational analysis based on this structure. PMID: 15755456
    17. May possibly be associated with the development of tropical pulmonary eosinophilia. PMID: 16014847
    18. Elevated glycosylated form of EDN in urine is associated with ovarian cancer PMID: 16428483
    19. EGO is a novel ncRNA gene expressed during eosinophil development and is necessary for normal MBP and EDN transcript expression. PMID: 17351112
    20. Data show that uEPX/c levels did not correlate with established markers of asthma severity and eosinophilic airway inflammation in atopic asthmatic children. PMID: 17641730
    21. MAZ and Sp1 play important roles on the transcriptional activation of the human edn promoter through specific binding to a 34-nt segment present in representative primate eosinophil rnase promoters. PMID: 17927842
    22. Urinary concentrations of eosinophil-derived neurotoxin in patients with atopic dermatitis show a significant positive correlation with disease severity. PMID: 17965582
    23. EDN can activate myeloid DCs by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway PMID: 18195069
    24. In three continental population groups (Asia, Europe, Africa), the angiogenin and RNase 2 genes appear to exhibit markedly less genetic heterogeneity with regard to T195C and A238G (ANG) and C425A (RNASE2) SNPs. PMID: 18636464
    25. No variation in genes encoding eosinophil-derived neurotoxin for Atopic dermatitis pathogenesis in this German cohort. PMID: 19014520
    26. the roles of the six discrete segments in transcription regulation were investigated and the -350/-329 region (ednR2) was shown to be involved in the regulation of edn expression PMID: 19115260
    27. ECP and EDN disrupt skin integrity and cause inflammation PMID: 19717523

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  • 亞細(xì)胞定位：
    Lysosome. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.
  • 蛋白家族：
    Pancreatic ribonuclease family
  • 組織特異性：
    Liver, lung, spleen, leukocytes and body fluids.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10045

    OMIM: 131410

    KEGG: hsa:6036

    STRING: 9606.ENSP00000303276

    UniGene: Hs.728