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  4. Human thyrotropin-releasing hormone,TRH ELISA KIT

Human thyrotropin-releasing hormone,TRH ELISA KIT

  • 中文名稱：
    人促甲狀腺素釋放激素(TRH)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E08146h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人促甲狀腺素釋放激素(TRH)酶聯(lián)免疫試劑盒（CSB-E08146h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿樣本中的TRH含量。TRH即促甲狀腺激素釋放激素，它由下丘腦分泌，可刺激腺垂體分泌促甲狀腺激素。其背景在于它是調(diào)節(jié)甲狀腺功能的重要神經(jīng)內(nèi)分泌激素。研究機(jī)制主要圍繞其對(duì)甲狀腺軸的調(diào)控，及在神經(jīng)系統(tǒng)中對(duì)神經(jīng)遞質(zhì)釋放、神經(jīng)細(xì)胞生長(zhǎng)分化等方面作用展開。試劑盒檢測(cè)范圍為2.5 pg/mL-100 pg/mL，本試劑盒適用于科研領(lǐng)域中對(duì)TRH表達(dá)水平的精準(zhǔn)定量分析，可應(yīng)用于神經(jīng)內(nèi)分泌調(diào)節(jié)機(jī)制研究、甲狀腺功能相關(guān)疾病模型建立、內(nèi)分泌系統(tǒng)與代謝關(guān)聯(lián)性探索等方向。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    TRH ELISA Kit; Pro-thyrotropin-releasing hormone ELISA Kit; Pro-TRH ELISA Kit; Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone ELISA Kit; TRH ELISA Kit; Protirelin ELISA Kit; TSH-releasing factor ELISA Kit; Thyroliberin ELISA Kit; Thyrotropin-releasing factor ELISA Kit; TRF)] ELISA Kit
  • 縮寫：
    TRH
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma
  • 檢測(cè)范圍：
    2.5 pg/mL-100 pg/mL
  • 靈敏度：
    1.25 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<15%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<15%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human TRH in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 86
    Range % 81-92
    1:2 Average % 95
    Range % 85-105
    1:4 Average % 97
    Range % 92-102
    1:8 Average % 93
    Range % 86-98
  • 回收率：
    The recovery of human TRH spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 94 89-98
    EDTA plasma (n=4) 97 91-100
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average
    100 2.232 2.252 2.242
    50 1.196 1.156 1.176
    25 0.635 0.648 0.642
    12.5 0.357 0.362 0.360
    5 0.146 0.151 0.149
    2.5 0.075 0.079 0.077
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.
  • 基因功能參考文獻(xiàn)：
    1. TRH rs13097335 may have a protective role toward the development of breast cancer. PMID: 25362934
    2. Data indicate that decrease of cholesterol level impaired the functional coupling between the thyrotropin-releasing hormone receptor and the cognate G proteins. PMID: 25485475
    3. Cpe mutations in mouse may affect processing of prothyrotropin releasing hormone into thyrotropin releasing hormone. PMID: 12270926
    4. TRH inhibits melanin-concentrating hormone (MCH) neurons by increasing synaptic inhibition from local GABA neurons. PMID: 22378876
    5. This study introduces TRH as a novel, potent, selective, and evolutionarily highly conserved neuroendocrine factor controlling human pigmentation in situ. PMID: 21956127
    6. Case Report: Isolated idiopathic central hypothyroidism in an adult, possibly caused by thyrotropin releasing hormone (TRH) deficiency. PMID: 20687402
    7. Thus, human scalp hair follicles are both a source and a target of TRH, which operates as a potent hair-growth stimulator PMID: 19825978
    8. TRH mRNA levels in "mute" thyrotropinomas: cause-effect or coincidence? PMID: 12067454
    9. results show that that leptin can regulate trh gene expression via activation of intracellular signal transducer and activator of transcription 3 (STAT3) proteins in TRH neurons in the hypothalamus PMID: 14764629
    10. The presence of TRH in dysplastic nevi may be predictive for the development of melanoma. PMID: 15328193
    11. Our results support the hypothesis that patients with pseudohypoparathyroidism Ia have impaired sensitivity to both TSH and TRH. PMID: 18805917

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    TRH family
  • 組織特異性：
    Hypothalamus. Expressed in the hair follicle epithelium (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12298

    OMIM: 613879

    KEGG: hsa:7200

    STRING: 9606.ENSP00000303452

    UniGene: Hs.182231