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  4. Human tissue inhibitors of metalloproteinase 4,TIMP-4 ELISA Kit

Human tissue inhibitors of metalloproteinase 4,TIMP-4 ELISA Kit

  • 中文名稱：
    人基質(zhì)金屬蛋白酶抑制因子4(TIMP-4)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E04735h
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3200/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    人基質(zhì)金屬蛋白酶抑制因子4(TIMP-4)酶聯(lián)免疫試劑盒（CSB-E04735h）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿、乳汁樣本中的TIMP4含量。TIMP4，即組織金屬蛋白酶抑制因子4，是一種抑制基質(zhì)金屬蛋白酶（MMPs）活性的蛋白質(zhì)，參與調(diào)節(jié)細(xì)胞外基質(zhì)重塑，影響組織發(fā)育、維護(hù)和修復(fù)。TIMP4在多種癌癥中表達(dá)變化具有特異性，與腫瘤轉(zhuǎn)移、免疫抑制等密切相關(guān)，可能成為潛在的治療靶點(diǎn)。試劑盒檢測(cè)范圍為0.313 ng/mL-20 ng/mL，靈敏度為0.005 ng/mL?？捎糜谔骄啃难芗膊∧Ｐ椭蠺IMP - 4的動(dòng)態(tài)變化、腫瘤微環(huán)境基質(zhì)代謝調(diào)控機(jī)制、組織修復(fù)過(guò)程中的分子網(wǎng)絡(luò)，以及哺乳期生物標(biāo)志物研究等方向。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見(jiàn)產(chǎn)品說(shuō)明書(shū)。
  • 別名：
    Metalloproteinase inhibitor 4 ELISA Kit; TIMP 4 ELISA Kit; TIMP metallopeptidase inhibitor 4 ELISA Kit; TIMP-4 ELISA Kit; Timp4 ELISA Kit; TIMP4_HUMAN ELISA Kit; Tissue inhibitor of metalloproteinase 4 ELISA Kit; Tissue inhibitor of metalloproteinases 4 ELISA Kit
  • 縮寫(xiě)：
    TIMP4
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, human milk
  • 檢測(cè)范圍：
    0.313 ng/mL-20 ng/mL
  • 靈敏度：
    0.005 ng/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 最新研究進(jìn)展：
    TIMP4，全稱為組織抑制金屬蛋白酶4（tissue inhibitor of metalloproteinases 4），是一種重要的金屬蛋白酶抑制劑。最新的研究表明，TIMP4可能在多種生理和病理過(guò)程中起到關(guān)鍵作用，包括心血管疾病、腫瘤、肝病和神經(jīng)退行性疾病等。研究者們正在努力深入研究TIMP4的作用機(jī)制，以期為相關(guān)疾病的治療提供新的靶點(diǎn)和策略。
  • 功能：
    Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
  • 基因功能參考文獻(xiàn)：
    1. MMP2/TIMP4 ratio is a marker of disease severity and right ventricular function as well as a predictor for survival and time to clinical worsening in idiopathic pulmonary arterial hypertension. PMID: 28516393
    2. Aspirin-HPR did not affect the translocation and release of MMPs and TIMP-4 from platelets. PMID: 28770228
    3. Combining two biomarkers significantly improved discrimination of AHRE. CONCLUSION: TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers. PMID: 28431065
    4. Our findings provide new evidence that LOX regulates SNAI2 expression and that SNAI2-mediated TIMP4 secretion plays a role in cancer progression. PMID: 27029493
    5. This report provides the first example that TIMP-4 regulates carcinogenesis through enriching the tumor progenitor cell population in cervical cancer cells. PMID: 26618609
    6. Concluding, miR-200b-3p mediates regulation of TIMP4 expression in prostate cancer but exact mechanism needs to be investigated. PMID: 28028835
    7. regulates carcinogenesis through apoptosis activation in cervical cancer cells PMID: 26291714
    8. Upregulation of plasma TIMP-4 might contribute to PIH [pregnancy-induced hypertension] processes PMID: 25986893
    9. This study provides evidence that the promoter TIMP4 rs3755724 is a new focal epilepsy susceptibility variant that is plausibly involved in inflammation-induced seizures in Malaysian Chinese. PMID: 25595263
    10. Selective myocardial targeting for TIMP-4 induction through either a viral or transgenic approach favorably altered the course of adverse left ventricular remodeling post-myocardial infarction. PMID: 24637197
    11. The rs3755724 in TIMP4 protein was nominally associated with schizophrenia with poor concentration. PMID: 23229788
    12. Heterogeneous methylation in the promoter region of TIMP4 was associated with cancer progression in non-small cell lung cancer. PMID: 22018271
    13. A trend toward increased serum levels of MMP-9/TIMP-4 was found in patients with successful arteriovenous fistulas. PMID: 21620625
    14. Plasma TIMP-4 has a role in the prediction of LV remodeling and the pathophysiology of the heart postinfarction PMID: 21624734
    15. MMP-10 and -7 abundance increased, accompanied by decreased TIMP-4 in dilated cardiomyopathy failing hearts compared with non-failing hearts. PMID: 20219015
    16. TIMP4 expression is a downstream target of GCM1 PMID: 21406447
    17. Expressions of MMP1, MMP9, TIMP4, and EMMPRIN were significantly unbalanced in the myocardium of congestive heart failure patients with rheumatic heart diseases. PMID: 19734590
    18. this work provides the first evidence of a TIMP-4/CD63 association in astrocytoma tumor cells PMID: 20693981
    19. TIMP-4 overexpression is associated with joint tissue remodeling and pathogenesis of osteoarthritic cartilage PMID: 11948685
    20. TIMP-4 is the major intraplatelet matrix metalloproteinase inhibitor and it is involved in regulation of platelet aggregation and recruitment. PMID: 12466243
    21. Progress curve analysis of MMP inhibition by TIMP-4 indicates that association rate constants and inhibition constants are similar to those for other TIMPs; TIMP-4 has a 5-fold lower binding affinity for proMMP-2 than does TIMP-2. PMID: 12475252
    22. Results suggest a functional relationship between TIMP-4 mRNA and MMP-26 mRNA, and possibly a role in human implantation. PMID: 15273280
    23. TIMP-4 displayed negligible activity against TACE, N-TIMP-4 is a slow tight-binding inhibitor with low nanomolar binding affinity PMID: 15713681
    24. TIMP-4 is expressed de novo in cervical cancer PMID: 15816637
    25. In conclusion, the data demonstrate upregulation of TIMP4 in human cardiovascular disorders exhibiting inflammation, suggesting its future use as a novel systemic marker for vascular inflammation. PMID: 16521002
    26. Maximal expression of TIMP-4 in the early and mid-secretory phase suggests its role during implantation and results show that TIMP-4 control the the relaese of MMP-26 in both stroma and uterine fluid. PMID: 16809379
    27. Results indicate that MMP-26 and TIMP-4 may play an integral role during the conversion of high-grade prostatic intraepithelial neoplasia to invasive cancer and may also serve as markers for early prostate cancer diagnosis. PMID: 16940965
    28. Enzyme immunoassays showed the levels of type 4 tissue inhibitor of metalloproteinases were virtually the same in colorectal cancer and mucosa. PMID: 18214300
    29. C/T polymorphism which is located on the 3'-untranslational regions of the TIMP-4 gene might be associated with susceptibility to Osteoarthritis in a Korean population PMID: 18301898
    30. Peroxynitrite-induced nitration and oligomerization of TIMP-4 attenuated its inhibitory activity against MMP-2 activity and endothelial or tumor cell invasiveness. PMID: 18336787
    31. TIMP4 is related to the development of KD with CALs in Korean children. PMID: 19048177
    32. a cardiopulmonary vasculature-specific role of TIMP-4 activation in systemic sclerosis. PMID: 19190762
    33. MMP-3 and TIMP-4 polymorphisms affect angiographic coronary plaque progression in type 2 diabetic and non-diabetic patients PMID: 19376102
    34. TIMP-4 as a simple prognostic marker that may help identify patients with early-stage breast cancer who could benefit from more aggressive treatment at diagnosis PMID: 19700750

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Protease inhibitor I35 (TIMP) family
  • 組織特異性：
    Abundant in heart and present at low levels in many other tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 11823

    OMIM: 601915

    KEGG: hsa:7079

    STRING: 9606.ENSP00000287814

    UniGene: Hs.591665