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  4. Monkey monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP1/MCAF ELISA kit

Monkey monocyte chemotactic protein 1/monocyte chemotactic and activating factor,MCP1/MCAF ELISA kit

  • 中文名稱：
    猴子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E10045Mo
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3800/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    猴子單核細胞趨化蛋白1(MCP-1/CCL2/MCAF)酶聯(lián)免疫試劑盒（CSB-E10045Mo）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CCL2含量。CCL2 是一種趨化因子，廣泛參與炎癥反應(yīng)、免疫調(diào)節(jié)等生理病理過程。其背景在于在多種疾病如腫瘤、炎癥性疾病中高表達。研究機制方面，它主要通過與受體結(jié)合，招募巨噬細胞等免疫細胞，在疾病發(fā)生發(fā)展進程中發(fā)揮重要作用。試劑盒檢測范圍為62.5 pg/mL-4000 pg/mL，適用于靈長類動物模型研究中MCP - 1表達水平的動態(tài)監(jiān)測，例如炎癥性疾病機制探索、免疫治療藥物效果評估或腫瘤微環(huán)境相關(guān)研究，為體外實驗中蛋白定量分析提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    CCL2 ELISA kit; MCP1 ELISA kit; SCYA2C-C motif chemokine 2 ELISA kit; Monocyte chemoattractant protein 1 ELISA kit; Monocyte chemotactic protein 1 ELISA kit; MCP-1 ELISA kit; Small-inducible cytokine A2 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Monkey
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    62.5 pg/mL-4000 pg/mL
  • 靈敏度：
    15.6 pg/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    40002.418 2.352 2.385 2.186
    20001.982 1.876 1.929 1.730
    10001.413 1.404 1.409 1.210
    5000.816 0.961 0.889 0.690
    2500.543 0.524 0.534 0.335
    1250.374 0.359 0.367 0.168
    62.50.302 0.289 0.296 0.097
    00.201 0.197 0.199 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 數(shù)據(jù)庫鏈接：