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  4. Mouse ADM2(ADM2) ELISA kit

Mouse ADM2(ADM2) ELISA kit

  • 中文名稱：
    小鼠ADM2(ADM2)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL001371MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠ADM2(ADM2)酶聯(lián)免疫試劑盒（CSB-EL001371MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的ADM2含量。小鼠ADM2（腎上腺髓質(zhì)素2）是一種編碼降鈣素基因相關(guān)肽（CGRP）的基因，其在心血管穩(wěn)態(tài)、催乳素釋放、抗利尿等方面發(fā)揮作用。研究顯示，ADM2通過基因敲除和條件性敲除小鼠模型，有助于理解其在心血管疾病和腫瘤發(fā)生中的作用機(jī)制。試劑盒檢測范圍為62.5 pg/mL-4000 pg/mL，本試劑盒適用于科研領(lǐng)域中對(duì)小鼠模型中ADM2表達(dá)動(dòng)力學(xué)的研究，例如在肥胖、糖尿病或高血壓等疾病機(jī)制探索中，通過檢測血清、血漿循環(huán)標(biāo)志物或特定組織（如脂肪、心肌）勻漿中的ADM2濃度，定量評(píng)估其與生理病理進(jìn)程的關(guān)聯(lián)性。為體外實(shí)驗(yàn)提供可靠的數(shù)據(jù)支持，助力于基礎(chǔ)醫(yī)學(xué)研究與藥物開發(fā)中的靶點(diǎn)功能解析。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Adm2 ELISA kit; Am2Protein ADM2 ELISA kit; Intermedin) [Cleaved into: Adrenomedullin-2 ELISA kit; AM2 ELISA kit; Intermedin-long ELISA kit; IMDL); Intermedin-short ELISA kit; IMDS)] ELISA kit
  • 縮寫：
    ADM2
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    62.5 pg/mL-4000 pg/mL
  • 靈敏度：
    15.6 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.; May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
  • 基因功能參考文獻(xiàn)：
    1. IMD may be an important self-protective factor in response to sepsis. PMID: 29980671
    2. Intermedin attenuated neointima formation in the mouse model of common carotid-artery ligation injury. IMD protection may be mediated by maintaining a vascular smooth muscle cell contractile phenotype via the cAMP/PKA pathway. PMID: 29053988
    3. results indicate that endogenous AM2 might be involved in energy metabolism in adipocytes through the upregulation of UCP1 expression PMID: 26786353
    4. ADM2 enhances subcutaneous White Adipose Tissue beiging via a direct effect by activating the CRLR.RAMP1-cAMP/PKA and p38 MAPK pathways in white adipocytes and via an indirect effect by stimulating alternative M2 polarization in macrophages. PMID: 27621315
    5. Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3. PMID: 27553639
    6. IMD reduces bone resorption by inhibiting osteoblast apoptosis, decreasing the RANKL/OPG ratio and the expression of M-CSF, and inhibiting osteoclast maturation and differentiation. PMID: 26398911
    7. Adrenomedullin-2/intermedin(8-47) ameliorates early ischemia/reperfusion injury in mouse lungs by protecting the integrity of the blood-air barrier and by potently reducing leukocyte influx into the alveolar space PMID: 25290159
    8. Intermedin attenuates macrophage foam-cell formation via tristetraprolin-mediated degradation of CD36 mRNA. PMID: 24253523
    9. increased stability of PTEN by intermedin leads to SR-A inhibition in macrophages, which ameliorates foam-cell formation and atherosclerosis in apoE(-/-) mice. PMID: 22841663
    10. Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3, but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR), and RAMP1 and RAMP2. PMID: 22563471
    11. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes PMID: 14615490
    12. Our data suggest that IMD acutely augments cardiomyocyte contractile function through, at least in part, a protein kinase C- and protein kinase A-dependent mechanism. PMID: 16763098
    13. tissue adrenomedullin 2 intermedin content was positively correlated with the diastolic blood pressure and negatively correlated with pulse pressure PMID: 19680258
    14. IMD is a novel hypoxia-induced gene and a potential interventional agent for the improvement of endothelial barrier function in systemic inflammatory responses and hypoxia-induced vascular leakage. PMID: 19684198

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Adrenomedullin family
  • 組織特異性：
    High expression detected in the submaxillary gland, kidney, stomach, and mesentery, followed by the pituitary, lung, pancreas, intestines, spleen, thymus and ovary. Expressed mainly in the intermediate lobe of the pituitary, with sporadic in the anterior
  • 數(shù)據(jù)庫鏈接：