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  4. Mouse Adropin(ENHO) ELISA kit

Mouse Adropin(ENHO) ELISA kit

  • 中文名稱：
    小鼠Adropin蛋白(ENHO)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-EL007669MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠Adropin蛋白(ENHO)酶聯(lián)免疫試劑盒（CSB-EL007669MO）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的ENHO含量。試劑盒檢測(cè)范圍為0.312 pg/mL-20 pg/mL，適用于肥胖、糖尿病、代謝綜合征等動(dòng)物模型研究，支持科研人員探究 Adropin 在能量代謝異常、組織特異性調(diào)控中的分子機(jī)制，也可用于評(píng)估藥物干預(yù)或基因編輯后生物樣本中 Adropin 的動(dòng)態(tài)變化，為代謝性疾病的基礎(chǔ)研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Enho ELISA Kit; Adropin ELISA Kit; Energy homeostasis-associated protein ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    0.312 pg/mL-20 pg/mL
  • 靈敏度：
    0.078 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Others
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：

  • 線性度：

  • 回收率：

  • 標(biāo)準(zhǔn)曲線：

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the regulation of glucose homeostasis and lipid metabolism.
  • 基因功能參考文獻(xiàn)：
    1. Adropin prevents atherosclerosis development by suppressing monocyte-endothelial cell adhesion and smooth muscle cell proliferation. PMID: 29701665
    2. An inverse correlation between serum adropin levels and mouse age that was attenuated by calorie restriction. PMID: 28922017
    3. our data suggest that adropin is a membrane-bound protein that interacts with the brain-specific Notch1 ligand NB3. PMID: 25074942
    4. these results suggest a role for adropin in regulating muscle substrate preference under various nutritional states. PMID: 24848071
    5. Release of adropin in the fed condition regulates fuel selection in skeletal muscle, promoting glucose oxidation over fat oxidation. The molecular mechanisms of adropin's effects involve acetylation (suggesting inhibition) of the transcriptional co-activator PGC1alpha, reducing PDK4 and CPT1B activity. Increased PGC1alpha acetylation by adropin may be mediated by inhibiting Sirtuin-1 (SIRT1), a PGC1alpha deacetylase. PMID: 24848071
    6. a potential endothelial protective role of adropin that is likely mediated via upregulation of endothelial NO synthase expression through the VEGFR2-phosphatidylinositol 3-kinase-Akt and VEGFR2-extracellular signal regulated kinase 1/2 pathways. PMID: 20837912
    7. Adropin has an endothelial protective function mediated via upregulation of eNOS expression through the VEGFR2-PI3K-Akt and VEGFR2-ERK1/2 pathways. Adropin therapy may thus be useful for limiting diseases characterized by endothelial dysfunction. PMID: 20837912
    8. Adropin regulated expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma, a major regulator of lipogenesis. PMID: 19041763
    9. Adropin is the name given to the secreted peptide encoded by human C9orf165. In mice, it is abundant in liver where it is regulated by dietary macronutrients. Adropin regulates expression of genes involved in lipogenesis and adipogenesis. PMID: 19041763

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  • 亞細(xì)胞定位：
    Secreted.
  • 組織特異性：
    Expressed in liver and brain. Expressed in regions of the brain involved in metabolic regulation.
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: mmu:69638

    UniGene: Mm.372459