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Mouse Alpha-2-macroglobulin(A2M) ELISA kit

  • 中文名稱:
    小鼠α2巨球蛋白(A2M)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL001004MO
  • 規(guī)格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    小鼠α2巨球蛋白(A2M)酶聯(lián)免疫試劑盒(CSB-EL001004MO)為競爭法ELISA試劑盒,定量檢測血清、血漿樣本中的A2M含量。A2M(α-2-巨球蛋白)是一種血漿蛋白,在人體生理過程中發(fā)揮重要作用。它可抑制多種蛋白酶活性,參與調(diào)節(jié)免疫反應(yīng)、炎癥過程等。研究機(jī)制主要圍繞其與蛋白酶結(jié)合模式、對細(xì)胞信號傳導(dǎo)的影響等,在疾病診斷和治療領(lǐng)域有潛在應(yīng)用價值。試劑盒檢測范圍為0.156 μg/mL-10 μg/mL,適用于小鼠模型中的炎癥機(jī)制研究、免疫調(diào)控通路探索或藥物干預(yù)后A2M動態(tài)變化的定量分析,為心血管疾病、肝纖維化等領(lǐng)域的科研實驗提供可靠工具。實驗操作兼容常規(guī)酶標(biāo)儀檢測,滿足體外研究中對生物標(biāo)志物的定量需求。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Pzp ELISA Kit; A2m ELISA Kit; Pregnancy zone protein ELISA Kit; Alpha-2-macroglobulin ELISA Kit; Alpha-2-M) [Cleaved into: Alpha-2-macroglobulin 165 kDa subunit; Alpha-2-macroglobulin 35 kDa subunit] ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 樣本類型:
    serum, plasma
  • 檢測范圍:
    0.156 μg/mL-10 μg/mL
  • 靈敏度:
    0.039 μg/mL
  • 反應(yīng)時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Competitive
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能:
    Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Protease inhibitor I39 (alpha-2-macroglobulin) family
  • 組織特異性:
    Highest expression in liver, medium expression in ovary, heart and stomach. Low expression in lung, kidney and uterus. Protein found in plasma.
  • 數(shù)據(jù)庫鏈接: