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  4. Mouse Apolipoprotein A5(apo-A5)ELISA Kit

Mouse Apolipoprotein A5(apo-A5)ELISA Kit

  • 中文名稱：
    小鼠載脂蛋白A5(apo-A5)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E16332m
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠載脂蛋白A5(apo-A5)酶聯(lián)免疫試劑盒（CSB-E16332m）為競爭法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的APOA5含量。APOA5是重要的血脂相關(guān)靶點。它參與脂質(zhì)代謝，可調(diào)節(jié)甘油三酯水平。研究發(fā)現(xiàn)其通過影響脂蛋白脂肪酶活性等機制對血脂產(chǎn)生作用。深入研究APOA5的作用機制，有望為高脂血癥等相關(guān)疾病的治療提供新的靶點和策略。試劑盒檢測范圍為125 pg/ml-2000 pg/ml.，靈敏度為31.2 pg/ml.。該產(chǎn)品適用于基礎(chǔ)科研領(lǐng)域，如探究apo - A5在脂代謝調(diào)控中的分子機制、評估藥物干預對脂蛋白代謝的影響，或用于構(gòu)建代謝紊亂動物模型時監(jiān)測apo - A5的動態(tài)變化。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Apoa5 ELISA Kit; Rap3Apolipoprotein A-V ELISA Kit; Apo-AV ELISA Kit; ApoA-V ELISA Kit; Apolipoprotein A5 ELISA Kit; Regeneration-associated protein 3 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    125 pg/ml-2000 pg/ml.
  • 靈敏度：
    31.2 pg/ml.
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cancer
  • 測定原理：
    quantitative
  • 測定方法：
    Competitive
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin.
  • 基因功能參考文獻：
    1. ApoA-V is a novel regulator of lipid metabolism in cardiomyocytes. PMID: 29530023
    2. e0192740 PMID: 29425239
    3. novel role for ApoA5 as a modulator of susceptibility to diet-induced liver and muscle insulin resistance through regulation of ectopic lipid accumulation in liver and skeletal muscle. PMID: 25548259
    4. The data suggest that apoA-V suppresses the production of chylomicrons, playing a previously unknown role in lipid metabolism that may contribute to the postprandial hypertriglyceridemia associated with apoA-V deficiency. PMID: 25617349
    5. Data indicate that apolipoprotein A5 (APOA5) plays a role in the central regulation of food intake. PMID: 23650188
    6. Gene transfer of human apoA-V improves the severe hypertriglyceridemia phenotype of apoa5 null mice. PMID: 23329134
    7. Intravenously injected apoA-V rHDL significantly lowers plasma TG in an apoA-V deficient mouse model and requires gpihbp1. PMID: 20966404
    8. Data show that livers from apolipoprotein A-V (APOA-V) transgenic mice contain significantly higher amounts of triglycerides than livers from wild-type or apoA-V knockout mice, suggesting that apoA-V influences intrahepatic triglyceride levels. PMID: 20153840
    9. Preferential association of apoA-V(1-146) with murine plasma HDL, but not with VLDL, suggests that particle size is a determinant of its lipoprotein binding specificity. PMID: 19825998
    10. a role of ApoA-V in regulating levels of circulating triglycerides and cholesterol. PMID: 12135615
    11. Review. APOA5 represents a newly discovered gene involved in triglyceride metabolism in both humans and mice whose mechanism of action remains to be deciphered. PMID: 12615678
    12. apoAV lowers plasma TG by both reducing the hepatic VLDL-TG production rate and by enhancing the lipolytic conversion of TG-rich lipoproteins PMID: 15090553
    13. ApoAIV is a direct target gene of Liver X receptors (LXRs) that may contribute to the antiatherogenic effect of LXR activation PMID: 15131258
    14. apo A-IV and apo A-V are positive acute-phase proteins in mouse HDL. PMID: 15306172
    15. apoAV reduces triglyceride levels by guiding VLDL and chylomicrons to proteoglycan-bound LPL for lipolysis PMID: 15774484
    16. in staggerer mice, apoa5 gene is not affected by RORalpha PMID: 15790933
    17. absence of apoAV slows lipolysis of triglyceride rick lipoprotein and the removal of their remnants by regulating their apoproteins content after secretion PMID: 16166565
    18. These data demonstrate that (i) apoA-V expression decreases early during the APR due to changes in mRNA stability, and (ii) during the APR apoA-V is not inversely related to plasma TG levels in mice and humans. PMID: 16325772
    19. APOA5 could also influence cholesterol homeostasis and probably play a role in hypertriglyceridemia associated with diabetes and inflammation. PMID: 16448983
    20. and metabolic consequences and phenotype of the three APOA5 mutations reported to date, which lead to premature truncations of apoAV are described PMID: 17222847
    21. These data suggest that in addition to its TG-lowering effect, apoA-V plays a significant role in modulating HDL maturation and cholesterol metabolism. PMID: 17438339
    22. oxidized fatty acids may act through an APOA5/APOClll mechanism that contributes to lowering of TG levels other than PPAR* induction PMID: 18243209
    23. the apoCIII enhancer contributes to the maintenance of an active chromatin subdomain of the apoAI/CIII/AIV genes, but not apoAV PMID: 18678879
    24. Data suggest that higher plasma apolipoprotein AV levels reflect an increased demand for plasma triglyceride hydrolysis under normal physiological conditions. PMID: 19141870
    25. These findings are consistent with the presence of a functional PPAR-binding element in the promoter of the human APOA5 gene; this element is however degenerate and non-functional in the corresponding mouse Apoa5 sequence. PMID: 19362162

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  • 亞細胞定位：
    Secreted. Early endosome. Late endosome. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    Apolipoprotein A1/A4/E family
  • 組織特異性：
    Liver.
  • 數(shù)據(jù)庫鏈接：