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  4. Mouse Apolipoprotein D(APOD) ELISA kit

Mouse Apolipoprotein D(APOD) ELISA kit

  • 中文名稱：
    小鼠載脂蛋白D(APOD)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL001935MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠載脂蛋白D(APOD)酶聯(lián)免疫試劑盒（CSB-EL001935MO）檢測血清、血漿樣本中的APOD含量。小鼠載脂蛋白D（APOD）是一種高密度脂蛋白成分，主要存在于血漿中，與視黃醇結(jié)合蛋白和α2微球蛋白超家族成員結(jié)合。其在多種生理和病理過程中發(fā)揮作用，如神經(jīng)保護(hù)和脂質(zhì)代謝，但其具體機(jī)制和功能尚需進(jìn)一步研究。試劑盒檢測范圍為12.5 ng/ml-200 ng/ml，本試劑盒適用于小鼠疾病模型研究中APOD表達(dá)水平的動態(tài)監(jiān)測，例如在代謝性疾病、神經(jīng)退行性病變及炎癥相關(guān)實驗中的生物標(biāo)志物分析，同時支持藥物干預(yù)或基因調(diào)控實驗的效應(yīng)評估本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    ApodApolipoprotein D ELISA kit; Apo-D ELISA kit; ApoD ELISA kit
  • 縮寫：
    APOD
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma
  • 檢測范圍：
    12.5 ng/ml-200 ng/ml.
  • 靈敏度：
    3.12 ng/ml.
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 精密度：
     批內(nèi)差CV%<12%，批間差CV%<15%
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of mouse APOD in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1000 Average % 97  
    Range % 92-106  
    1:2000 Average % 90  
    Range % 83-99  
    1:4000 Average % 89  
    Range % 86-99  
    1:8000 Average % 92  
    Range % 87-102  
  • 回收率：
     
  • 標(biāo)準(zhǔn)曲線：
     
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
  • 基因功能參考文獻(xiàn)：
    1. Study shows that in myelin maturation ApoD ultimately controls the removal of the sialic-rich hydrophilic glycocalyx, by maintaining functional integrity of lysosomes. A detailed analysis of the mechanism reveals that the proper localization of Neu1 and plasma membrane Neu3, as well as of the membrane-bound Fyn kinase, depend on ApoD. PMID: 29222871
    2. apoD protein levels are variable across different brain regions. PMID: 26829325
    3. It regulates amyloid plaque pathology in a mouse model of Alzheimer's disease PMID: 25784209
    4. apoD may be part of an intrinsic cardioprotective system, possibly as a consequence of its antioxidation activity. PMID: 24082102
    5. Changes in hypothalamus of ApoD(-/-) mice may indicate potential role of ApoD in regulation of endocrine functions of somatostatin in a receptor-dependent manner. PMID: 22581439
    6. Abeta25-35 induces neuroprotective ApoD expression in hippocampal cells in response to stress-induced growth arrest. PMID: 22398376
    7. The findings underscore the importance of ApoD in the regulation of plasma insulin levels and triglyceride metabolism, suggesting that ApoD plays an important role in the pathogenesis of dyslipidemia. PMID: 21632073
    8. The data of this study supported that ApoD contributes to the endurance of astrocytes and decreases their reactivity level in vitro and in vivo PMID: 21688324
    9. Scanning cytometry revealed PACAP/ApoD induced low density lipoprotein receptors (LDLR) and ApoE receptor 2 (apoER2) in NF200-positive cells. PMID: 20920539
    10. mRNA and protein expression profiles reveal that ApoD is functionally connected in an age-dependent manner to specific molecular programs triggered by injury. PMID: 20607718
    11. Apolipoprotein D plays a significant role in lipid metabolism. PMID: 20124557
    12. This study concluded that glutamatergic pathways seem to be particularly affected in ApoD(-/-) mice. PMID: 19963028
    13. Expression pattern of the lipocalin apolipoprotein D during mouse embryogenesis. PMID: 11744388
    14. Apolipoprotein D-immunolabeled cells are observed in select grey matter nuclei, including the globus pallidus, thalamus, and substantia nigra, and in white matter tracts within the internal capsule and cerebellum of Neimann-Pick type C mouse brain. PMID: 12815234
    15. apolipoprotein D and the lipogenic protein Spot 14 are LXR alpha and LXRB responsive genes both in vitro and in vivo PMID: 14703507
    16. ApoD messenger RNA expression was localised to the spiral ligament and spiral limbus, particularly in the suprastrial and supralimbral regions. PMID: 15668042
    17. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids. PMID: 18419796
    18. Taken together, our results describe receptor and region specific changes in SST and SSTR subtypes expression in ApoD(-/-) mice brain, which may be linked to specific neurological disorders. PMID: 19465111

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 組織特異性：
    Highest levels of expression in brain, testis, virgin mammary gland and salivary gland. Moderate levels in skeletal muscle, lactating mammary gland and thymus. Low levels in lung and lymph node. No expression in kidney, pancreas, liver or spleen.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:11815

    STRING: 10090.ENSMUSP00000110885

    UniGene: Mm.2082