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  4. Mouse C-X-C motif chemokine 11(CXCL11) ELISA kit

Mouse C-X-C motif chemokine 11(CXCL11) ELISA kit

  • 中文名稱：
    小鼠C-X-C趨化因子11(CXCL11)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL006241MO
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠C-X-C趨化因子11(CXCL11)酶聯(lián)免疫試劑盒（CSB-EL006241MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織培養(yǎng)上清液,組織勻漿樣本中的CXCL11含量。CXCL11 是一個(gè)重要靶點(diǎn)。其背景上，它在免疫調(diào)節(jié)等生理過程中起關(guān)鍵作用。研究機(jī)制方面，它主要通過與特定受體結(jié)合，激活下游信號通路，參與炎癥反應(yīng)、腫瘤微環(huán)境調(diào)節(jié)等，如今在腫瘤、自身免疫病等研究領(lǐng)域受廣泛關(guān)注。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，適用于基礎(chǔ)科研中炎癥機(jī)制研究、免疫調(diào)節(jié)實(shí)驗(yàn)或藥物開發(fā)模型的生物標(biāo)志物分析；為科研人員探索CXCL11在感染性疾病、腫瘤微環(huán)境及免疫相關(guān)疾病中的功能提供了可靠工具，適用于分子生物學(xué)、免疫學(xué)等領(lǐng)域的基礎(chǔ)研究；血清/血漿適用于體內(nèi)病理模型分析，細(xì)胞培養(yǎng)上清可用于體外細(xì)胞因子分泌研究，而組織勻漿則滿足組織特異性表達(dá)檢測需求本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Cxcl11 ELISA Kit; Scyb11C-X-C motif chemokine 11 ELISA Kit; Interferon-inducible T-cell alpha chemoattractant ELISA Kit; I-TAC ELISA Kit; Small-inducible cytokine B11 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, cell culture supernates,tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
  • 基因功能參考文獻(xiàn)：
    1. although the expression of CXCL9 and CXCL11 are increased after spinal nerve ligation, they may not contribute to the maintenance of neuropathic pain. PMID: 29712506
    2. These findings functionally integrate K17, hnRNP K, and gene expression along with RSK and CXCR3 signaling in a keratinocyte-autonomous axis and provide a potential basis for their implication in tumorigenesis PMID: 25713416
    3. very low doses of CXCL11 rapidly suppress signs of EAE in C57BL/6 mice lacking functional CXCL11. PMID: 24713654
    4. Data indicate that epidermis-derived I-TAC (Cxcl11) triggers a sustained Th2-response that determines the outcome of a complex immunological process. PMID: 24398292
    5. Analysis of genes within the Listr1 locus identified a frameshift mutation in the Cxcl11 gene of the C57BL/6 strain that prevents production of the mature chemokine CXCL11. PMID: 24566892
    6. Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development. PMID: 22277947
    7. the CXCL11-heparin interaction has two different affinities for glycosaminoglycans PMID: 20363748
    8. I-TAC can have an important role during virus infections and vaccinia virus has evolved ways to avoid inducing I-TAC expression. PMID: 15030574
    9. I-TAC acts as an antagonist for CCR5. I-TAC inhibited the binding of macrophage-inflammatory protein-1alpha (MIP-1alpha)/CC chemokine ligand 3 (CCL3) to cells transfected with CCR5 and to monocytes. PMID: 15178708
    10. Acute ethanol intoxication impairs lung expression of Cxcl11, interfering with pulmonary response to bacterial challenge. PMID: 17889309
    11. homologous to human T cell attracting chemokine CXC receptor ligand 11; involved in calcium mobilization and chemotaxis PMID: 11500837

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:56066

    UniGene: Mm.131723